Directors and Executive Officers
Directors And Executive Officers [Member]
Directors And Executive Officers
65 Grove Street Lease
65 Grove Street, Watertown, MA [Member]
65 Grove Street, Watertown, MA [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Vested and expected to vest, term
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Statistical Measurement [Domain]
Statistical Measurement [Domain]
Related-Party Transactions
Related Party Transactions Disclosure [Text Block]
Schedule of Components of Lease Costs and Additional Information Related to Operating Leases
Lease, Cost [Table Text Block]
Government assistance, potential additional award amount
Government Assistance, Potential Additional Award Amount
Government Assistance, Potential Additional Award Amount
Cover [Abstract]
Cover [Abstract]
Net change in cash, cash equivalents, and restricted cash
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Issuance of CVRs upon exercise of warrants (in shares)
Issuance of Contingent Value Right for Exercise of Warrants
Issuance of Contingent Value Right for Exercise of Warrants
Schedule of Maturity of Operating Lease Liabilities
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Thereafter
Lessee, Operating Lease, Liability, To Be Paid, After Year Four
Lessee, Operating Lease, Liability, To Be Paid, After Year Four
Trading Symbol
Trading Symbol
Segment Reporting Information [Line Items]
Segment Reporting Information [Line Items]
All Trading Arrangements
All Trading Arrangements [Member]
Schedule of Cash and Cash Equivalents [Table]
Cash and Cash Equivalent [Table]
Compensation Actually Paid vs. Net Income
Compensation Actually Paid vs. Net Income [Text Block]
Non-NEOs
Non-NEOs [Member]
Schedule of Computation of Basic and Diluted Net Loss Per Share Allocable to Common Stockholders
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Award vesting term
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Rule 10b5-1 Arrangement Adopted
Rule 10b5-1 Arrangement Adopted [Flag]
Awards Close in Time to MNPI Disclosures
Awards Close in Time to MNPI Disclosures [Table]
Schedule of Stock-Based Compensation Expense
Share-Based Payment Arrangement, Cost by Plan [Table Text Block]
Issuance of common stock upon exercise of warrants and Conversion of Series A Preferred Stock to common stock (in shares)
Stock Issued During Period, Shares, Conversion of Convertible Securities
Upfront rental payment
Upfront Rental Payment
Upfront Rental Payment
Pay vs Performance Disclosure [Line Items]
Peer Group Total Shareholder Return Amount
Peer Group Total Shareholder Return Amount
Accounts receivable
Increase (Decrease) in Accounts Receivable
Description of the Business
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Non-Rule 10b5-1 Arrangement Adopted
Non-Rule 10b5-1 Arrangement Adopted [Flag]
Property and equipment
Accrued Property, Plant And Equipment, Current
Accrued Property, Plant And Equipment, Current
Fair Value Measurements
Fair Value Disclosures [Text Block]
Proceeds from exercise of stock options
Proceeds from Stock Options Exercised
Restructuring and Related Activities [Abstract]
Award Timing Disclosures [Line Items]
Number of shares authorized, increase (in shares)
Share-Based Compensation Arrangement By Share-Based Payment Award, Number Of Shares Available For Grant, Increase (Decrease)
Share-Based Compensation Arrangement By Share-Based Payment Award, Number Of Shares Available For Grant, Increase (Decrease)
Proceeds from issuance of Series A Preferred Stock, gross in private placement
Proceeds from Issuance of Preferred Stock and Preference Stock
Other Performance Measure, Amount
Other Performance Measure, Amount
Leases
Lessee, Operating Leases [Text Block]
Common stock, shares outstanding (in shares)
Common stock, beginning balance (in shares)
Common stock, ending balance (in shares)
Common Stock, Shares, Outstanding
Operating lease cost
Operating Lease, Cost
Class of Warrant or Right [Axis]
Class of Warrant or Right [Axis]
Number of shares authorized for grants (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Lease liability, net of current portion
Operating Lease, Liability, Noncurrent
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Cash flows from financing activities
Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Segment Information
Segment Reporting, Policy [Policy Text Block]
Warrants and rights outstanding, term
Warrants and Rights Outstanding, Term
Revenue from Contract with Customer [Abstract]
Revenue from Contract with Customer [Abstract]
Plan Name [Domain]
Plan Name [Domain]
Sale of stock, price per share (in dollars per share)
Sale of Stock, Price Per Share
Operating Leased Assets [Line Items]
Operating Leased Assets [Line Items]
Other assets
Other Assets, Noncurrent
Entity Tax Identification Number
Entity Tax Identification Number
Leases [Abstract]
Leases [Abstract]
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name [Domain]
Weighted-average fair value of common stock (in dollars per share)
Share-Based Compensation Arrangement By Share-Based Payment Award, Fair Value Assumptions, Weighted Average Fair Value
Weighed-average fair value relating to the share-based payment award.
Money market funds (included in cash equivalents)
Money Market Funds [Member]
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Equity securities, stock purchase agreement, par value per share (in dollars per share)
Equity Securities, Stock Purchase Agreement, Par Value Per Share
Equity Securities, Stock Purchase Agreement, Par Value Per Share
Total aggregate purchase price
Sale of Stock, Consideration Received on Transaction
Collaboration and License Agreements
Collaboration And License Agreements [Text Block]
Collaboration And License Agreements
Old Cartesian
Old Cartesian [Member]
Old Cartesian
Base rent upward annual adjustment percentage after first year
Lessee, Operating Lease, Base Rent, Annual Upward Adjustment Percentage After Year One
Lessee, Operating Lease, Base Rent, Annual Upward Adjustment Percentage After Year One
Transfer of Series A Preferred Stock and options for Series A Preferred Stock to permanent equity
Transfer Of Temporary Equity To Permanent Equity
Transfer Of Temporary Equity To Permanent Equity
Plan Name [Axis]
Plan Name [Axis]
Equity Components [Axis]
Equity Components [Axis]
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Award Timing Method
Award Timing Method [Text Block]
Office equipment
Office Equipment [Member]
Trading Arrangements, by Individual
Trading Arrangements, by Individual [Table]
Measurement Frequency [Axis]
Measurement Frequency [Axis]
SOBI
Swedish Orphan Biovitrum AB (SOBI) [Member]
Swedish Orphan Biovitrum AB (SOBI)
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
License and option agreement, benchmark royalties, maximum
License And Option Agreement, Benchmark Royalties, Maximum
License And Option Agreement, Benchmark Royalties, Maximum
License and option agreement, royalty payment
License And Option Agreement, Royalty Payment
License And Option Agreement, Royalty Payment
Insider Trading Policies and Procedures [Line Items]
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Business Acquisition, Acquiree [Domain]
Business Acquisition, Acquiree [Domain]
Adjustment to Compensation, Amount
Adjustment to Compensation Amount
Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Payables and Accruals [Abstract]
Payables and Accruals [Abstract]
Compensation Amount
Outstanding Recovery Compensation Amount
Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table
Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table [Member]
Schedule of Operating Leased Assets [Table]
Schedule of Operating Leased Assets [Table]
Entity Smaller Reporting Company
Entity Small Business
Company Selected Measure Amount
Company Selected Measure Amount
Tabular List, Table
Tabular List [Table Text Block]
Aggregate amount for future payments upon achievement of clinical and regulatory approval milestones for products containing ImmTOR platform
Aggregate Amount For Future Payments Upon Achievement Of Clinical And Regulatory Approval Milestones For Products Containing ImmTOR Platform
Aggregate Amount For Future Payments Upon Achievement Of Clinical And Regulatory Approval Milestones For Products Containing ImmTOR Platform
Level 3
Fair Value, Inputs, Level 3 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Fair Value Measurement Inputs and Valuation Techniques [Table]
Fair Value Measurement Inputs and Valuation Techniques [Table]
Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table
Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table [Member]
Series A Preferred Stock options
Series A Preferred Stock Options [Member]
Series A Preferred Stock Options
Old Cartesian Plan
Old Cartesian Plan [Member]
Old Cartesian Plan
Accrued expenses
Accrued Liabilities, Current
Total (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Dividend yield
Measurement Input, Expected Dividend Rate [Member]
Cash Payments
Payments for Restructuring
Class of Warrant or Right [Line Items]
Class of Warrant or Right [Line Items]
National Institute of Neurological Disorders and Stroke of the National Institutes of Health Funding
National Institute Of Neurological Disorders And Stroke Of The National Institutes Of Health Funding [Member]
National Institute Of Neurological Disorders And Stroke Of The National Institutes Of Health Funding
Convertible preferred stock, common stock issuable upon conversion (in shares)
Preferred Stock, Convertible, Shares Issuable
Schedule of Supplemental Disclosure for the Statement of Cash Flows Related to Operating Leases
Operating Lease, Lease Income [Table Text Block]
Credit Facility [Domain]
Credit Facility [Domain]
Cash, cash equivalents, and restricted cash at beginning of period
Cash, cash equivalents, and restricted cash at end of period
Total cash, cash equivalents, and restricted cash
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents
Lease Arrangement [Domain]
Lease Arrangement [Domain]
[Domain] for Lease Arrangement [Axis]
Contingent value right liability
Contingent Value Right Liability
Contingent Value Right Liability
Current assets:
Assets, Current [Abstract]
Goodwill
Goodwill
Indefinite-Lived Intangible Assets, Major Class Name [Domain]
Indefinite-Lived Intangible Assets, Major Class Name [Domain]
Vested (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Weighted Average Exercise Price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Weighted Average Exercise Price
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Product and Service [Domain]
Product and Service [Domain]
Outstanding common stock options
Outstanding Series A Preferred Stock options
Options
Share-Based Payment Arrangement, Option [Member]
Short-term lease cost
Short-Term Lease, Cost
Vested (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Depreciation expense
Depreciation
Fair Value Disclosures [Abstract]
Fair Value Disclosures [Abstract]
2026
Lessee, Operating Lease, Liability, to be Paid, Year One
License
License [Member]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Antidilutive Security, Excluded EPS Calculation [Table]
Total comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Preferred stock, shares outstanding (in shares)
Preferred stock, beginning balance (in shares)
Preferred stock, ending balance (in shares)
Preferred Stock, Shares Outstanding
Warrants to purchase common stock
Warrant liabilities
Exercise of warrants
Warrant [Member]
Security Exchange Name
Security Exchange Name
Revenue recognized from performance obligations related to prior periods as a result of change in transaction price
Contract with Customer, Liability, Cumulative Catch-up Adjustment to Revenue, Change in Estimate of Transaction Price
Award Type [Axis]
Award Type [Axis]
Net loss per share:
Earnings Per Share, Basic [Abstract]
Equity Interest Type [Axis]
Equity Interest Type [Axis]
Exercised (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Number of shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Net
NCI Agreement
National Cancer Institute Agreement [Member]
National Cancer Institute Agreement
Total liabilities
Liabilities
Schedule of Cash and Cash Equivalents
Schedule of Cash and Cash Equivalents [Table Text Block]
Research and development stock-based compensation expense
Research And Development, Share Based Payment Arrangement, Expense [Member]
Research And Development, Share Based Payment Arrangement, Expense
Schedule of Intangible Assets Acquired
Schedule of Acquired Indefinite-Lived Intangible Assets by Major Class [Table Text Block]
Common stock, par value (in dollars per share)
Common Stock, Par or Stated Value Per Share
Forgone Recovery, Explanation of Impracticability
Forgone Recovery, Explanation of Impracticability [Text Block]
Research and development
Research and Development Expense
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Expiration Date
Trading Arrangement Expiration Date
Payments of contingent value rights distributions
Payments For Contingent Value Rights Distributions
Payments For Contingent Value Rights Distributions
Genovis AB
Genovis AB [Member]
Genovis AB
Goodwill and Intangible Assets Disclosure [Abstract]
Goodwill and Intangible Assets Disclosure [Abstract]
Class of warrant or right, number of securities called by each warrant or right (in shares)
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right
Grant revenue
Revenue Not from Contract with Customer
Lease liability
Operating Lease, Liability, Current
Total Shareholder Return Amount
Total Shareholder Return Amount
Common stock, shares issued (in shares)
Common Stock, Shares, Issued
Equity Awards Adjustments, Footnote
Equity Awards Adjustments, Footnote [Text Block]
Computer equipment and software
Computer Equipment [Member]
Insider Trading Policies and Procedures Adopted
Insider Trading Policies and Procedures Adopted [Flag]
Less: Accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
3SBio License
License Agreement With Shenyang Sunshine Pharmaceutical Company Limited [Member]
Represents information pertaining to License agreement with Shenyang Sunshine Pharmaceutical co., ltd.
Total property and equipment
Property, Plant and Equipment, Gross
Obligation to issue stock (in shares)
Settlement Of Derivative Liability, Shares
Settlement Of Derivative Liability, Shares
Descartes-08 for SLE
Descartes-08 for SLE [Member]
Descartes-08 for SLE
Issuance of common stock upon exercise of options (in shares)
Exercised (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Named Executive Officers, Footnote
Named Executive Officers, Footnote [Text Block]
Weighted-average exercise price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Research and development
Research and Development Expense [Member]
Common stock, shares authorized (in shares)
Common Stock, Shares Authorized
Class of Warrant or Right [Table]
Class of Warrant or Right [Table]
Diluted (in shares)
Weighted-average common shares outstanding - diluted (in shares)
Weighted Average Number of Shares Outstanding, Diluted
MNPI Disclosure Timed for Compensation Value
MNPI Disclosure Timed for Compensation Value [Flag]
Research and development facilities and other expenses
Research And Development, Facilities And Other Expenses [Member]
Research And Development, Facilities And Other Expenses
Vested, term
Share-Based Compensation Arrangement By Share-Based Payment Award, Options, Vested, Outstanding, Weighted Average Remaining Contractual Term
Share-Based Compensation Arrangement By Share-Based Payment Award, Options, Vested, Outstanding, Weighted Average Remaining Contractual Term
Numerator:
Net Income (Loss) Available to Common Stockholders, Basic [Abstract]
Total stockholders’ deficit
Beginning balance
Ending balance
Equity, Attributable to Parent
Related Party
Related Party [Member]
Lease renewal term (in years)
Lessee, Operating Lease, Renewal Term
Cash and Cash Equivalents [Line Items]
Cash and Cash Equivalents [Line Items]
Additional annual base rent for first year
Lessee, Operating Lease, Additional Annual Base Rent, Year One
Lessee, Operating Lease, Additional Annual Base Rent, Year One
Cash flows from investing activities
Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract]
2016 Plan
Stock Incentive Plan 2016 [Member]
Represents the information pertaining to the 2016 stock incentive plan, which provides for the granting of stock based awards to employees, directors, and consultants under terms and provisions established by the board of directors.
Property and Equipment
Property, Plant and Equipment Disclosure [Text Block]
Increase (Decrease) In Temporary Equity, Option, Roll Forward [Roll Forward]
Increase (Decrease) In Temporary Equity, Option, Roll Forward [Roll Forward]
Increase (Decrease) In Temporary Equity, Option, Roll Forward
Interest income
Investment Income, Net
Milestone payment
License And Option Agreement, Milestone Payments
License And Option Agreement, Milestone Payments
Recurring
Fair Value, Recurring [Member]
Accounts receivable
Accounts Receivable, after Allowance for Credit Loss, Current
Granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Asset impairment charges
Asset Impairment Charges
Potential common shares
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Sale of Stock [Domain]
Sale of Stock [Domain]
Pension Adjustments Prior Service Cost
Pension Adjustments Prior Service Cost [Member]
Document Fiscal Period Focus
Document Fiscal Period Focus
All Executive Categories
All Executive Categories [Member]
Schedule of Change in Accrued Restructuring Balance
Schedule of Restructuring Reserve by Type of Cost [Table Text Block]
Changed Peer Group, Footnote
Changed Peer Group, Footnote [Text Block]
Outstanding, term
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Assets
Assets [Abstract]
Legacy Selecta programs
Legacy Selecta Programs [Member]
Legacy Selecta Programs
Proceeds from exercise of common warrants
Proceeds from Warrant Exercises
Dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Document Type
Document Type
7495 New Horizon Way Leases
7495 New Horizon Way Lease [Member]
7495 New Horizon Way Lease
Change in fair value of forward contract liabilities
Forward contract liabilities revaluation
Gain (Loss) on Derivative Instruments, Net, Pretax
Pension Benefits Adjustments, Footnote
Pension Benefits Adjustments, Footnote [Text Block]
Schedule of Segment Reporting Information, by Segment
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Total Shareholder Return Vs Peer Group
Total Shareholder Return Vs Peer Group [Text Block]
Issuance of vested restricted stock units (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Gross
Transfer of Series A Preferred Stock and options for Series A Preferred Stock to permanent equity (in shares)
Transfer Of Temporary Equity To Permanent Equity, Shares
Transfer Of Temporary Equity To Permanent Equity, Shares
Vested (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Warrant liabilities, net of current portion
Warrants And Rights Outstanding, Noncurrent
Warrants And Rights Outstanding, Noncurrent
Risk-free interest rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
In-process research and development assets
Total in-process research and development assets
Indefinite-Lived Intangible Assets (Excluding Goodwill)
Maximum
Maximum [Member]
Contract liability
Contract with Customer, Liability
Equity Valuation Assumption Difference, Footnote
Equity Valuation Assumption Difference, Footnote [Text Block]
Written notice for agreement termination
Collaborative Arrangement, Written Notice Period For Termination
Collaborative Arrangement, Written Notice Period For Termination
Furniture and fixtures
Furniture and Fixtures [Member]
Antidilutive Securities [Axis]
Antidilutive Securities [Axis]
Accounts payable
Accounts Payable, Current
Accounting Policies [Abstract]
Accounting Policies [Abstract]
Revenue:
Revenues [Abstract]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Leasehold improvements
Leasehold Improvements [Member]
Schedule of Weighted Average Assumptions Used
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Current Fiscal Year End Date
Current Fiscal Year End Date
Less: Imputed interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Lessee-paid construction costs
Total lease cost
Lease, Cost
Valuation technique, option pricing model
Valuation Technique, Option Pricing Model [Member]
Non-current assets:
Assets, Noncurrent [Abstract]
Statistical Measurement [Axis]
Statistical Measurement [Axis]
PEO Name
PEO Name
Beginning balance (in shares)
Ending balance (in shares)
Class of Warrant or Right, Outstanding
Non-Rule 10b5-1 Arrangement Terminated
Non-Rule 10b5-1 Arrangement Terminated [Flag]
Non-PEO NEO Average Total Compensation Amount
Non-PEO NEO Average Total Compensation Amount
Award Type [Domain]
Award Type [Domain]
Name
Outstanding Recovery, Individual Name
Research and development employee expenses
Research And Development, Employee Expenses [Member]
Research And Development, Employee Expenses
Disaggregation of Revenue [Line Items]
Disaggregation of Revenue [Line Items]
Variable lease cost
Variable Lease, Cost
Schedule of Potential Dilutive Shares of Common Stock Excluded from the Computation of the Diluted Net Loss Per Share Allocable to Common Stockholders
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Compensation Actually Paid vs. Company Selected Measure
Compensation Actually Paid vs. Company Selected Measure [Text Block]
Estimated probability of success
Probability Of Success [Member]
Probability Of Success
Non-PEO NEO
Non-PEO NEO [Member]
Title of Individual [Axis]
Title and Position [Axis]
Temporary equity, par value (in dollars per share)
Temporary Equity, Par or Stated Value Per Share
Accrued expenses and other current liabilities
Accrued Liabilities and Other Liabilities
Additional paid-in capital
Additional Paid-in Capital [Member]
Award Timing Predetermined
Award Timing Predetermined [Flag]
2016 Plan, 2018 Inducement Incentive Award Plan and Old Cartesian Plan
2016 Plan, 2018 Inducement Incentive Award Plan and Old Cartesian Plan [Member]
2016 Plan, 2018 Inducement Incentive Award Plan and Old Cartesian Plan
Class of Stock [Line Items]
Class of Stock [Line Items]
Fixed semi annual amount
Contingent Value Right Liability, Deduction From Distribution, General And Administrative Overhead
Contingent Value Right Liability, Deduction From Distribution, General And Administrative Overhead
Long-term restricted cash
Restricted Cash, Noncurrent
Recent Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Diluted (in dollars per share)
Earnings Per Share, Diluted
Series A Preferred Stock
Series A Preferred Stock [Member]
Class of Stock [Axis]
Class of Stock [Axis]
Title of Individual [Domain]
Title and Position [Domain]
Issuance of Series A Preferred Stock in connection with private placement and settlement of related forward contract
Temporary Equity, Stock Issued During Period, Value, New Issues
Counterparty Name [Domain]
Counterparty Name [Domain]
Name
Measure Name
Entity Interactive Data Current
Entity Interactive Data Current
Deferred revenue
Increase (Decrease) in Contract with Customer, Liability
Restatement does not require Recovery
Restatement Does Not Require Recovery [Text Block]
Schedule of Warrant Activity
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Government Assistance, Type [Axis]
Government Assistance, Type [Axis]
Number of operating segments
Number of Operating Segments
Number of positions eliminated, period percent
Restructuring and Related Cost, Number of Positions Eliminated, Period Percent
Change in fair value of warrant liabilities
Warrant liabilities revaluation
Fair Value Adjustment of Warrants
Preferred stock, shares issued (in shares)
Preferred Stock, Shares Issued
Schedule of Assets and Liabilities Measured at Fair Value on a Recurring Basis
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Disaggregation of Revenue [Table]
Disaggregation of Revenue [Table]
Other comprehensive loss:
Other Comprehensive Income (Loss), Tax [Abstract]
Statement of Financial Position [Abstract]
Statement of Financial Position [Abstract]
Operating lease, cost (as a percent)
Operating Lease, Cost Percentage
Operating Lease, Cost Percentage
Restructuring
Restructuring and Related Activities Disclosure [Text Block]
Estimated forfeitures rate
Share-based Compensation Arrangement By Share-based Payment Award Forfeitures Rate
Represents the percentage of forfeitures rate of the stock options based on the historical trends.
Stock-based compensation expense
Share-Based Payment Arrangement, Noncash Expense
Weighted average period
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Collaboration and license revenue
Revenue from Contract with Customer, Excluding Assessed Tax
Timothy A. Springer, Ph.D.
Dr. Timothy A. Springer [Member]
Dr. Timothy A. Springer
Other (income) expense, net
Nonoperating Income (Expense)
Statement of Comprehensive Income [Abstract]
Statement of Comprehensive Income [Abstract]
Net cash used in investing activities
Net Cash Provided by (Used in) Investing Activities
Operating loss
Operating Income (Loss)
Business Acquisition [Line Items]
Business Acquisition [Line Items]
Total liabilities, convertible preferred stock, and stockholders’ deficit
Liabilities and Equity
Subsequent Events
Subsequent Events [Text Block]
Rule 10b5-1 Arrangement Terminated
Rule 10b5-1 Arrangement Terminated [Flag]
All Adjustments to Compensation
All Adjustments to Compensation [Member]
Tenant improvement recognized as reduction in right-of-use asset and lease liability
Operating Lease, Tenant Improvement Allowance Recognized as Reduction in Right of Use Asset and Lease Liability
Operating Lease, Tenant Improvement Allowance Recognized as Reduction in Right of Use Asset and Lease Liability
Payroll and employee related expenses
Employee-related Liabilities, Current
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV [Axis]
Prepaid expenses, deposits and other assets
Increase (Decrease) in Prepaid Expense and Other Assets
Additional paid-in capital
Additional Paid in Capital
Right-of-use asset impairment expense
Operating Lease, Impairment Loss
Restructuring charges
Charges
Restructuring Charges
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Vested
Share-Based Compensation Arrangement By Share-Based Payment Award, Options, Vested, Outstanding, Intrinsic Value
Share-Based Compensation Arrangement By Share-Based Payment Award, Options, Vested, Outstanding, Intrinsic Value
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies Disclosure [Abstract]
704 Quince Orchard Road Leases
704 Quince Orchard Road Leases [Member]
704 Quince Orchard Road Leases
Change in fair value of contingent value right liability
Contingent value right liability revaluation
Fair Value Adjustment Of Contingent Value Right Liability
Fair Value Adjustment Of Contingent Value Right Liability
Underlying Security Market Price Change
Underlying Security Market Price Change, Percent
Measurement Input Type [Axis]
Measurement Input Type [Axis]
Individual:
Individual [Axis]
Accumulated other comprehensive loss
AOCI Attributable to Parent [Member]
Forfeited (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Expected term (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Product and Service [Axis]
Product and Service [Axis]
Entity Address, State or Province
Entity Address, State or Province
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Statement [Line Items]
Statement [Line Items]
Measurement Input Type [Domain]
Measurement Input Type [Domain]
Erroneous Compensation Analysis
Erroneous Compensation Analysis [Text Block]
Schedule of Related Party Transactions
Schedule of Related Party Transactions [Table Text Block]
Descartes-08 for MG
Descartes-08 for MG [Member]
Descartes-08 for MG
Operating expenses:
Operating Expenses [Abstract]
Unvested restricted stock units
Restricted Stock Units, Unvested [Member]
Restricted Stock Units, Unvested
Schedule of Property and Equipment
Property, Plant and Equipment [Table Text Block]
Compensation Actually Paid vs. Total Shareholder Return
Compensation Actually Paid vs. Total Shareholder Return [Text Block]
Financial Instruments [Domain]
Financial Instruments [Domain]
Less: Sublease income
Sublease Income
Transfer of Series A Preferred Stock and options for Series A Preferred Stock to permanent equity
Temporary Equity, Transfer Of Preferred Stock To Permanent Equity
Temporary Equity, Transfer Of Preferred Stock To Permanent Equity
Unvested at beginning of period (in dollars per share)
Unvested at end of period (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Liabilities, convertible preferred stock, and stockholders’ deficit
Liabilities and Equity [Abstract]
Beginning balance
Ending balance
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value
Cash, cash equivalents, restricted cash and marketable securities
Cash, Cash Equivalents, Restricted Cash And Restricted Cash Equivalents And Debt Securities, Available-For-Sale
Cash, Cash Equivalents, Restricted Cash And Restricted Cash Equivalents And Debt Securities, Available-For-Sale
Weighted-average exercise price
Class Of Warrant Or Right Weighted Average Exercise Price [Roll Forward]
Class Of Warrant Or Right Weighted Average Exercise Price
Weighted-average remaining contractual term
Share-Based Compensation Arrangement By Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term [Abstract]
n/a
Contingent value right liability, measurement input
Contingent Value Right Liability, Measurement Input
Contingent Value Right Liability, Measurement Input
Minimum
Minimum [Member]
Restatement Determination Date
Restatement Determination Date
Vested and expected to vest (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Accrued professional and consulting services
Accrued Audit Fees, Current
Accrued Audit Fees, Current
Adoption Date
Trading Arrangement Adoption Date
Pay vs Performance Disclosure
Pay vs Performance Disclosure [Table]
Issuance of stock for settlement of liability
Issuance Of Stock For Settlement Of Forward Contract Liability
Issuance Of Stock For Settlement Of Forward Contract Liability
Warrants and rights outstanding, measurement input
Warrants and Rights Outstanding, Measurement Input
Related Party Transactions [Abstract]
Related Party Transactions [Abstract]
Government assistance, asset, current
Government Assistance, Asset, Current
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Table]
Beginning balance (in dollars per share)
Ending balance (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Right-of-use asset, net
Operating Lease, Right-of-Use Asset
Erroneously Awarded Compensation Recovery
Erroneously Awarded Compensation Recovery [Table]
Share-based compensation arrangement by share-based payment award, options, outstanding, number (in shares)
Beginning balance (in shares)
Ending balance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Number of Warrants
Class Of Warrant Or Right [Roll Forward]
Class Of Warrant Or Right
Number of acquired operating leases
Number Of Acquired Operating Leases
Number Of Acquired Operating Leases
Warrants exercised (in shares)
Class of Warrant Or Right, Exercised During Period
Class of Warrant Or Right, Exercised During Period
Segments [Axis]
Segments [Axis]
Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year
Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year [Member]
Schedule of Restricted Stock Units Activity
Disclosure of Share-Based Compensation Arrangements by Share-Based Payment Award [Table Text Block]
Property, Plant and Equipment [Abstract]
Property, Plant and Equipment [Abstract]
Exercise Price
Award Exercise Price
Securities Purchase Agreement
Securities Purchase Agreement [Member]
Securities Purchase Agreement
Net Loss Per Share Allocable to Common Stockholders
Earnings Per Share [Text Block]
Arrangement Duration
Trading Arrangement Duration
Issuance of common stock upon exercise of options
Stock Issued During Period, Value, Stock Options Exercised
Goodwill and Intangible Assets
Goodwill and Intangible Assets Disclosure [Text Block]
Stockholders’ deficit:
Equity, Attributable to Parent [Abstract]
Grants in period (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
2023 Private Placement
Private Placement 2023 [Member]
Private Placement 2023
Marketable Securities [Table]
Marketable Securities [Table]
Peer Group Issuers, Footnote
Peer Group Issuers, Footnote [Text Block]
Segments [Domain]
Segments [Domain]
Material Terms of Trading Arrangement
Material Terms of Trading Arrangement [Text Block]
All Individuals
All Individuals [Member]
Contingent Value Right
CVR liability
Contingent Value Right [Member]
Contingent Value Right
Depreciation and amortization
Other Depreciation and Amortization
Lease agreement, first month's rent paid upon execution of lease agreement
Lessee, Operating Lease, First Month Rent Paid on Execution of Lease Agreement
Lessee, Operating Lease, First Month Rent Paid on Execution of Lease Agreement
PEO
PEO [Member]
Contingent value right liability, net of current portion
Contingent Value Right Liability, Noncurrent
Contingent Value Right Liability, Noncurrent
Operating Segment
Operating Segment [Member]
Operating Segment
Income Tax Disclosure [Abstract]
Income Tax Disclosure [Abstract]
Name
Trading Arrangement, Individual Name
Other income, net
Other Nonoperating Income (Expense)
Statement of Stockholders' Equity [Abstract]
Statement of Stockholders' Equity [Abstract]
Equity securities, stock purchase agreement, purchase price per share (in dollars per share)
Equity Securities, Stock Purchase Agreement, Purchase Price Per Share
Equity Securities, Stock Purchase Agreement, Purchase Price Per Share
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset [Axis]
Unrecognized compensation expense
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Private Placement Two
Private Placement Two [Member]
Private Placement Two
Transfer of Series A Preferred Stock and options for Series A Preferred Stock to permanent equity (in shares)
Temporary Equity, Transfer Of Preferred Stock To Permanent Equity, Shares
Temporary Equity, Transfer Of Preferred Stock To Permanent Equity, Shares
Awards Close in Time to MNPI Disclosures, Table
Awards Close in Time to MNPI Disclosures [Table Text Block]
Assets:
Assets, Fair Value Disclosure [Abstract]
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Total (in shares)
Common Stock, Capital Shares Reserved for Future Issuance
Expected volatility
Measurement Input, Price Volatility [Member]
Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year
Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year [Member]
Related Party [Domain]
Related and Nonrelated Parties [Domain]
Fair value, measurement with unobservable inputs reconciliation, recurring basis, liability, transfers, net
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Transfers, Net
Money market funds (included in cash equivalents)
Cash and Cash Equivalents, Fair Value Disclosure
Aggregate Erroneous Compensation Amount
Aggregate Erroneous Compensation Amount
Restructuring Cost and Reserve [Line Items]
Restructuring Cost and Reserve [Line Items]
Local Phone Number
Local Phone Number
Liability Class [Axis]
Liability Class [Axis]
Aggregate Erroneous Compensation Not Yet Determined
Aggregate Erroneous Compensation Not Yet Determined [Text Block]
Total operating expenses
Operating Expenses
Deferred tax liabilities, net
Deferred Income Tax Liabilities, Net
Expected volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Valuation Approach and Technique [Axis]
Valuation Approach and Technique [Axis]
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
PEO Total Compensation Amount
PEO Total Compensation Amount
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Issuance of shares (in shares)
Business Acquisition, Equity Interest Issued or Issuable, Number of Shares
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset [Domain]
Schedule of Accrued Expenses
Schedule of Accrued Liabilities [Table Text Block]
Income Statement Location [Axis]
Statement of Income Location, Balance [Axis]
Vested and expected to vest (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Equity offering costs
Payments of Stock Issuance Costs
Series B Preferred Stock Purchase Agreement
Series B Preferred Stock Purchase Agreement [Member]
Series B Preferred Stock Purchase Agreement
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Impairment of long-lived assets
Impairment, Long-Lived Asset, Held-for-Use
Common stock
Common Stock [Member]
Measure:
Measure [Axis]
Reverse stock split conversion ratio
Stockholders' Equity Note, Stock Split, Conversion Ratio
Preferred stock, shares authorized (in shares)
Preferred Stock, Shares Authorized
Forgone Recovery due to Expense of Enforcement, Amount
Forgone Recovery due to Expense of Enforcement, Amount
Schedule of Business Acquisitions, by Acquisition [Table]
Schedule of Business Acquisitions, by Acquisition [Table]
Schedule of Roll-Forward of Fair Value for the Company’s Level 3 Warrant Liabilities, CVR Liability and Forward Contract Liabilities
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
July 2024 Purchase Agreement
July 2024 Purchase Agreement [Member]
July 2024 Purchase Agreement
Entity Emerging Growth Company
Entity Emerging Growth Company
Indefinite-Lived Intangible Assets [Axis]
Indefinite-Lived Intangible Assets [Axis]
Total liabilities
Liabilities, Fair Value Disclosure
Segment Reporting [Abstract]
Entity Central Index Key
Entity Central Index Key
Issuance of common stock upon exercise of warrants
Stock Issued During Period, Value, Common Warrants Exercised
Stock Issued During Period, Value, Common Warrants Exercised
General and administrative
General and Administrative Expense [Member]
Number of options to extend lease
Lessee, Operating Lease, Number Of Options To Extend
Lessee, Operating Lease, Number Of Options To Extend
Accrued Expenses
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Non-GAAP Measure Description
Non-GAAP Measure Description [Text Block]
Non-PEO NEO Average Compensation Actually Paid Amount
Non-PEO NEO Average Compensation Actually Paid Amount
Lease Arrangement [Axis]
Lease Arrangement [Axis]
Lease Arrangement [Axis]
Equity
Equity [Text Block]
Expected volatility of future revenues
Measurement Input, Revenue Volatility [Member]
Measurement Input, Revenue Volatility
Award Timing, How MNPI Considered
Award Timing, How MNPI Considered [Text Block]
Equity Component [Domain]
Equity Component [Domain]
Preferred stock, par value (in dollars per share)
Preferred Stock, Par or Stated Value Per Share
Financial Instrument [Axis]
Financial Instrument [Axis]
Beginning balance (in shares)
Ending balance (in shares)
Temporary Equity, Shares Outstanding
Segment Information
Segment Reporting Disclosure [Text Block]
Change in fair value
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings
Additional 402(v) Disclosure
Additional 402(v) Disclosure [Text Block]
Stock-based compensation expense
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Risk-free interest rate
Measurement Input, Risk Free Interest Rate [Member]
Fair value, measurement with unobservable inputs reconciliation, recurring basis, asset, transfers, net
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Transfers, Net
Entity Shell Company
Entity Shell Company
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Title
Trading Arrangement, Individual Title
Statement [Table]
Statement [Table]
2023 Securities Purchase Agreement
Securities Purchase Agreement 2023 [Member]
Securities Purchase Agreement 2023
Counterparty Name [Axis]
Counterparty Name [Axis]
Measurement Frequency [Domain]
Measurement Frequency [Domain]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
City Area Code
City Area Code
Current liabilities:
Liabilities, Current [Abstract]
Equity securities, stock purchase agreement, shares purchased (in shares)
Equity Securities, Stock Purchase Agreement, Shares Purchased
Equity Securities, Stock Purchase Agreement, Shares Purchased
Government assistance, award amount
Government Assistance, Award Amount
Insider Trading Policies and Procedures Not Adopted
Insider Trading Policies and Procedures Not Adopted [Text Block]
Level 1
Fair Value, Inputs, Level 1 [Member]
Foreign currency translation adjustment
Currency translation adjustment
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax
Total current assets
Assets, Current
Statement of Cash Flows [Abstract]
Statement of Cash Flows [Abstract]
Non-cash investing and financing activities
Noncash Investing and Financing Items [Abstract]
Preferred stock
Preferred Stock [Member]
Schedule of Segment Reporting Information, by Segment [Table]
Schedule of Segment Reporting Information, by Segment [Table]
Schedule of Fair Value Measurement Inputs and Valuation Techniques for 2022 Warrants Liability and CVR Liability
Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]
Weighted-average grant date fair value ($)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Weighted average grant date fair value of stock options (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Investments
Equity Securities without Readily Determinable Fair Value, Amount
Restructuring Reserve [Roll Forward]
Restructuring Reserve [Roll Forward]
Expected life (in years)
Measurement Input, Expected Term [Member]
Issuance of common stock upon exercise of warrants (in shares)
Stock Issued During Period, Shares, Common Warrants Exercised
Stock Issued During Period, Shares, Common Warrants Exercised
Income Taxes
Income Tax Disclosure [Text Block]
2029
Lessee, Operating Lease, Liability, to be Paid, Year Four
Net loss per share allocable to common stockholders:
Earnings Per Share [Abstract]
Equity [Abstract]
Equity [Abstract]
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Class of Stock [Domain]
Class of Stock [Domain]
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Equity Interest Issued or Issuable, Type [Domain]
Equity Interest Issued or Issuable, Type [Domain]
General and administrative
General and Administrative Expense
2022 Warrants
2022 Warrants [Member]
2022 Warrants
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Aggregate Available
Trading Arrangement, Securities Aggregate Available Amount
Equity Awards Adjustments
Equity Awards Adjustments [Member]
Operating lease, weighted average discount rate, percent
Weighted-average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Lease liabilities
Total operating lease liabilities
Operating Lease, Liability
Employment Inducement Incentive Award Plan
Employment Inducement Incentive Award Plan [Member]
Employment Inducement Incentive Award Plan [Member]
Net cash (used in) provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Unbilled receivable
Increase (Decrease) In Contract with Customer, Asset, Allowance for Credit Loss, Current
Increase (Decrease) In Contract with Customer, Asset, Allowance for Credit Loss, Current
Underlying Securities
Award Underlying Securities Amount
Investments
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Credit Facility [Axis]
Credit Facility [Axis]
Amendment Flag
Amendment Flag
Entity Registrant Name
Entity Registrant Name
Loss on disposal of property and equipment
Gain (Loss) on Disposition of Property Plant Equipment
Cash flows from operating activities
Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract]
Adjustment to Non-PEO NEO Compensation Footnote
Adjustment to Non-PEO NEO Compensation Footnote [Text Block]
Stock Appreciation Rights (SARs)
Stock Appreciation Rights (SARs) [Member]
Increase (Decrease) in Temporary Equity [Roll Forward]
Increase (Decrease) in Temporary Equity [Roll Forward]
Cyrus Biotechnology, Inc.
Cyrus Biotechnology, Inc. [Member]
Cyrus Biotechnology, Inc.
Schedule of Restricted Cash
Restrictions on Cash and Cash Equivalents [Table Text Block]
Fair Value as of Grant Date
Award Grant Date Fair Value
Subsequent Events [Abstract]
Subsequent Events [Abstract]
Non-cash lease expense
Finance Lease, Right-of-Use Asset, Amortization
Issuance of Series A Preferred Stock in connection with private placement and settlement of related forward contract (in shares)
Temporary Equity, Stock Issued During Period, Shares
Temporary Equity, Stock Issued During Period, Shares
Vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Level 2
Fair Value, Inputs, Level 2 [Member]
Sale of stock, number of shares issued in transaction (in shares)
Shares issued (in shares)
Sale of Stock, Number of Shares Issued in Transaction
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV [Domain]
Recovery of Erroneously Awarded Compensation Disclosure [Line Items]
Distributions
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Settlements
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Principles of Consolidation
Consolidation, Policy [Policy Text Block]
Schedule of Restructuring and Related Costs [Table]
Restructuring Cost [Table]
Restatement Determination Date:
Restatement Determination Date [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Title of 12(b) Security
Title of 12(b) Security
Common stock, $0.0001 par value; 350,000,000 shares authorized as of March 31, 2025 and December 31, 2024; 25,936,101 and 25,767,369 shares issued and outstanding as of March 31, 2025 and December 31, 2024, respectively
Common Stock, Value, Issued
Non-current liabilities:
Other Liabilities, Noncurrent [Abstract]
Share-based Payment Arrangement [Abstract]
Share-Based Payment Arrangement [Abstract]
Cash and cash equivalents
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested
Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested [Member]
Forfeited in period (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Fair Value by Liability Class [Domain]
Fair Value by Liability Class [Domain]
Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested
Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested [Member]
Contingent value right, percentage of milestone payments, royalties and other amounts to be distributed
Contingent Value Right, Percentage Of Milestone Payments, Royalties And Other Amounts To Be Distributed
Contingent Value Right, Percentage Of Milestone Payments, Royalties And Other Amounts To Be Distributed
Preferred stock, value, issued
Preferred Stock, Value, Issued
Transfer of Series A Preferred Stock and options for Series A Preferred Stock to permanent equity
Temporary Equity, Options, Transfer Of Preferred Stock To Permanent Equity
Temporary Equity, Options, Transfer Of Preferred Stock To Permanent Equity
Common stock options and restricted stock units
Shares available for future stock incentive awards
Share-Based Payment Arrangement [Member]
Number of Options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Cash and Cash Equivalents [Domain]
Cash and Cash Equivalents [Domain]
Beginning balance
Ending balance
Temporary Equity, Options, Carrying Amount, Attributable To Parent
Temporary Equity, Options, Carrying Amount, Attributable To Parent
Valuation Approach and Technique [Domain]
Valuation Approach and Technique [Domain]
Basic (in dollars per share)
Earnings Per Share, Basic
Accounts payable
Increase (Decrease) in Accounts Payable
Cash paid for amounts included in the measurement of lease liabilities:
Operating Lease, Payments
Adjustment To PEO Compensation, Footnote
Adjustment To PEO Compensation, Footnote [Text Block]
Award Timing MNPI Disclosure
Award Timing MNPI Disclosure [Text Block]
Award expiration term
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Purchase of property and equipment not yet paid
Capital Expenditures Incurred but Not yet Paid
Aggregate Pension Adjustments Service Cost
Aggregate Pension Adjustments Service Cost [Member]
Accrued patent fees
Accrued Patent Fees Current
Carrying value as of the balance sheet date of patent fees.
Laboratory equipment
Laboratory Equipment [Member]
Represents information pertaining to laboratory equipment.
Compensation Actually Paid vs. Other Measure
Compensation Actually Paid vs. Other Measure [Text Block]
Lease agreement, monthly base rent
Lessee, Operating Lease, Monthly Base Rent
Lessee, Operating Lease, Monthly Base Rent
Schedule of Stock by Class [Table]
Stock, Class of Stock [Table]
Total current liabilities
Liabilities, Current
Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year
Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year [Member]
Beginning balance
Ending balance
Temporary Equity, Carrying Amount, Attributable to Parent
Weighted-average common shares outstanding:
Denominator:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Unrecognized compensation expense related to unvested employee stock options
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Total assets
Assets
Future contingent additional payments
Revenue, Remaining Performance Obligation, Variable Consideration Amount
Revenue, Remaining Performance Obligation, Variable Consideration Amount
Grants in period (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Forgone Recovery due to Violation of Home Country Law, Amount
Forgone Recovery due to Violation of Home Country Law, Amount
Commitments and contingencies (Note 17)
Commitments and Contingencies
Termination Date
Trading Arrangement Termination Date
Class of Warrant or Right [Domain]
Class of Warrant or Right [Domain]
Basis of Presentation
Business Description and Basis of Presentation [Text Block]
Schedule of Related Party Transactions, by Related Party [Table]
Related Party Transaction [Table]
Beginning balance (in dollars per share)
Ending balance (in dollars per share)
Weighted average exercise price (in dollars per share)
Class of Warrant or Right, Exercise Price of Warrants or Rights
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total revenue
Revenues
2027
Lessee, Operating Lease, Liability, to be Paid, Year Two
Aggregate amount of upfront and milestone-based payments
Aggregate Amount Of Upfront And Milestone Based Payments Paid
Aggregate Amount Of Upfront And Milestone Based Payments Paid
Stock Incentive Plans
Share-Based Payment Arrangement [Text Block]
Entity Address, City or Town
Entity Address, City or Town
Early stage programs
Early Stage Programs [Member]
Early Stage Programs
Old Cartestian
Old Cartestian [Member]
Old Cartestian
Schedule of Options Activity
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Operating lease, expense
Operating Lease, Base Rent
Operating Lease, Base Rent
2019 Warrants
2019 Warrants [Member]
2019 Warrants
Stock‑based compensation expense
Total stock-based compensation expense
Share-Based Payment Arrangement, Expense
Net loss
Net loss
Net loss
Net Income (Loss) Attributable to Parent
Trading Arrangement:
Trading Arrangement [Axis]
Investments, Debt and Equity Securities [Abstract]
Granted (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Pay vs Performance Disclosure, Table
Pay vs Performance [Table Text Block]
Forfeited in period (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Business Acquisition [Axis]
Business Acquisition [Axis]
Area of office space leased
Area of Real Estate Property
Equity Awards Adjustments, Excluding Value Reported in Compensation Table
Equity Awards Adjustments, Excluding Value Reported in the Compensation Table [Member]
Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year
Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year [Member]
Entity File Number
Entity File Number
Accrued external research and development costs
Accrued Research And Development Costs Current
Carrying value as of the balance sheet date of research and development costs.
Cash and Cash Equivalents [Axis]
Cash and Cash Equivalents [Axis]
Liabilities:
Liabilities, Fair Value Disclosure [Abstract]
Series B Preferred Stock
Series B Preferred Stock [Member]
Revenue Arrangements
Revenue from Contract with Customer [Text Block]
Document Fiscal Year Focus
Document Fiscal Year Focus
Government Assistance, Type [Domain]
Government Assistance, Type [Domain]
At-The-Market Offering
At-The-Market Offering [Member]
At-The-Market Offering [Member]
Entity Address, Address Line One
Entity Address, Address Line One
Effect of exchange rate changes on cash
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Continuing Operations
Lease term
Lessee, Operating Lease, Term of Contract
Other
Other Accrued Liabilities, Current
Total assets
Assets, Fair Value Disclosure
Accrued expenses and other liabilities
Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities
Name
Forgone Recovery, Individual Name
2025 (remainder)
Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year
Aggregate maximum gross sales proceeds
Sale Of Stock, Aggregate Maximum Gross Sales Proceeds
Sale Of Stock, Aggregate Maximum Gross Sales Proceeds
Weighted-average remaining lease term
Operating Lease, Weighted Average Remaining Lease Term
Document Period End Date
Document Period End Date
Sale of Stock [Axis]
Sale of Stock [Axis]
Sale of stock, gross consideration received on transaction
Sale of Stock, Gross Consideration Received on Transaction
Sale of Stock, Gross Consideration Received on Transaction
Award Timing MNPI Considered
Award Timing MNPI Considered [Flag]
Total future minimum lease payments
Lessee, Operating Lease, Liability, to be Paid
Astellas
Audentes Therapeutics, Inc. (Astellas) [Member]
Audentes Therapeutics, Inc. (Astellas)
Unvested at beginning of period (in shares)
Unvested at end of period (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Insider Trading Arrangements [Line Items]
Outstanding Aggregate Erroneous Compensation Amount
Outstanding Aggregate Erroneous Compensation Amount
Schedule of Authorized Shares of Common Stock for Future Issuance
Schedule of Stock by Class [Table Text Block]
2028
Lessee, Operating Lease, Liability, to be Paid, Year Three
PEO Actually Paid Compensation Amount
PEO Actually Paid Compensation Amount
Revenue recognized
Contract with Customer, Liability, Revenue Recognized
Warrant liabilities
Warrants and Rights Outstanding
Adjustment to Compensation:
Adjustment to Compensation [Axis]
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Long-term restricted cash
Long-term restricted cash
Restricted Cash and Cash Equivalents, Noncurrent
Document Transition Report
Document Transition Report
Document Quarterly Report
Document Quarterly Report
Biogen M.A., Inc.
Biogen M.A., Inc. [Member]
Biogen M.A., Inc.
Fair Value, Recurring and Nonrecurring [Table]
Fair Value, Recurring and Nonrecurring [Table]
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax
Entity Current Reporting Status
Entity Current Reporting Status
Accumulated deficit
Retained Earnings [Member]
Restricted cash and cash equivalents
Restricted Cash and Cash Equivalents
Contingent value right liability
Contingent Value Right Liability, Current
Contingent Value Right Liability, Current
Pension Adjustments Service Cost
Pension Adjustments Service Cost [Member]
Related Party [Axis]
Related and Nonrelated Parties [Axis]
Basic (in shares)
Weighted-average common shares outstanding - basic (in shares)
Weighted Average Number of Shares Outstanding, Basic
Stock Price or TSR Estimation Method
Stock Price or TSR Estimation Method [Text Block]
Marketable Securities [Line Items]
Marketable Securities [Line Items]
Vested (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested, Number of Shares
Restricted Stock Units (RSUs)
Restricted Stock Units (RSUs) [Member]
Increase (Decrease) in Stockholders' Equity
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Executive Category:
Executive Category [Axis]
Name
Awards Close in Time to MNPI Disclosures, Individual Name
Construction in process
Construction in Progress [Member]
Aggregate intrinsic value
Share-Based Compensation Arrangement By Share-Based Payment Award, Options, Outstanding, Intrinsic Value [Abstract]
n/a
Forfeited (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Entity Filer Category
Entity Filer Category
Beginning Balance
Ending Balance
Restructuring Reserve
Unsatisfied performance obligation
Revenue, Remaining Performance Obligation, Amount
Income Statement Location [Domain]
Statement of Income Location, Balance [Domain]
Operating expenses:
Cost of Revenue [Abstract]
Letter of Credit
Letter of Credit [Member]
Company Selected Measure Name
Company Selected Measure Name