Debt Disclosure [Abstract]
Schedule of Long-term Debt Instruments [Table]
Schedule of Long-term Debt Instruments [Table]
Debt Instrument [Axis]
Debt Instrument [Axis]
Debt Instrument, Name [Domain]
Debt Instrument, Name [Domain]
Convertible Notes Payable
Convertible Notes Payable [Member]
Equity Components [Axis]
Equity Components [Axis]
Equity Component [Domain]
Equity Component [Domain]
Common stock
Common Stock [Member]
Class of Stock [Axis]
Class of Stock [Axis]
Class of Stock [Domain]
Class of Stock [Domain]
Conversion of Series E Preferred
Series E Redeemable Convertible Preferred Stock [Member]
Represents information pertaining to series E redeemable convertible preferred stock.
Range [Axis]
Range [Axis]
Range [Domain]
Range [Domain]
Maximum
Maximum [Member]
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Interest rate of convertible notes
Debt Instrument, Interest Rate, Stated Percentage
Percentage of convertible notes for which warrants were issued to purchase common stock
Percentage of Convertible Notes for Which Warrants Issued to Purchase Common Stock
Represents the percentage of convertible notes for which warrants issued to purchase equivalent common stock shares.
Exercise price (in dollars per share)
Class of Warrant or Right, Exercise Price of Warrants or Rights
Warrants issued for purchase of common stock (in shares)
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Term of warrants
Class Of Warrants Or Rights, Term
Period of time between issuance and maturity of warrant, in PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.
Shares issued on conversion of outstanding convertible notes (in shares)
Debt Conversion, Converted Instrument, Shares Issued
Interest expense related to convertible notes
Interest Expense, Debt
Property, Plant and Equipment [Abstract]
Property and Equipment
Property, Plant and Equipment Disclosure [Text Block]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Nature of the Business and Basis of Presentation
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Statement of Cash Flows [Abstract]
Operating activities
Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract]
Net loss
Net Income (Loss) Attributable to Parent
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Depreciation
Depreciation
Amortization of premiums and accretion of discounts on investments
Accretion (Amortization) of Discounts and Premiums, Investments
Stock‑based compensation expense
Allocated Share-based Compensation Expense
Non‑cash interest expense
Paid-in-Kind Interest
Change in fair value of redeemable convertible preferred stock warrant
Fair Value Adjustment of Warrants
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Accounts receivable
Increase (Decrease) in Accounts Receivable
Prepaid expenses and other assets
Increase (Decrease) in Prepaid Expense and Other Assets
Restricted cash and other deposits
Increase (Decrease) in Restricted Cash for Operating Activities
Accounts payable
Increase (Decrease) in Accounts Payable
Deferred revenue
Increase (Decrease) in Deferred Revenue
Contingently repayable grant funding
Increase Decrease In Contingently Repayable Grant Funding
The increase (decrease) during the reporting period in contingently repayable grant funding that are used in an entity's business.
Accrued expenses and other liabilities
Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities, Continuing Operations
Investing activities
Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract]
Maturities of short term government obligations
Proceeds from Maturities, Prepayments and Calls of Short-term Investments
Purchase of short term investments
Payments to Acquire Short-term Investments
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Net cash used in investing activities
Net Cash Provided by (Used in) Investing Activities, Continuing Operations
Financing activities
Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract]
Net proceeds from issuance of preferred stock and warrants
Proceeds from Issuance of Preferred Stock, Preference Stock, and Warrants
Vesting of restricted stock
Proceeds From Vesting Of Restricted Stock
The cash proceeds from the vesting of restricted stock.
Principle payments on loan payable
Repayments of Long-term Debt
Deferred IPO costs paid
Payments of Stock Issuance Costs
Issuance of convertible note
Proceeds from Convertible Debt
Proceeds from Initial Public Offering, net of underwriters' discounts and commissions
Proceeds from Issuance Initial Public Offering
Exercise of stock options
Proceeds from Stock Options Exercised
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities, Continuing Operations
Effect of exchange rate changes on cash
Effect of Exchange Rate on Cash and Cash Equivalents, Continuing Operations
Net increase in cash and cash equivalents
Cash and Cash Equivalents, Period Increase (Decrease)
Cash and cash equivalents at beginning of period
Cash and Cash Equivalents, at Carrying Value
Cash and cash equivalents at end of period
Cash paid during the year for:
Supplemental Cash Flow Information [Abstract]
Interest
Interest Paid
Supplemental noncash investing and financing activities:
Noncash Investing and Financing Items [Abstract]
Purchase of property and equipment not yet paid
Capital Expenditures Incurred but Not yet Paid
Reclassification of deferred IPO costs from non-current assets to additional paid-in capital
Noncash or Partial Noncash Reclassification Of Deferred IPO Costs From Non Current Assets To Additional Paid In Capital
Reclassification of deferred IPO costs from non-current assets to additional paid-in capital.
Accrued dividends and accretion of preferred stock to redemption value
Temporary Equity, Accretion to Redemption Value
Conversion of bridge loans into Series E preferred
Debt Conversion, Converted Instrument, Amount
Unrealized gain on marketable securities
Marketable Securities, Unrealized Gain (Loss)
Compensation and Retirement Disclosure [Abstract]
Defined Contribution Plan [Table]
Defined Contribution Plan [Table]
Defined Contribution Plan Name [Axis]
Defined Contribution Plan Name [Axis]
Defined Contribution Plan Name [Domain]
Defined Contribution Plan Name [Domain]
401(k) Plan
Defined Contribution401k Plan [Member]
Information pertaining to the 401K defined contribution plan.
Defined Contribution Plan Disclosure [Line Items]
Defined Contribution Plan Disclosure [Line Items]
Vesting period
Defined Contribution Plan Employers Matching Contribution Vesting Period
Period which an employee's right to exercise a plan is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.
Employer contribution made
Defined Contribution Plan, Cost Recognized
Commitments and Contingencies Disclosure [Abstract]
Schedule of Operating Leased Assets [Table]
Schedule of Operating Leased Assets [Table]
Lease Arrangement, Type [Axis]
Lease Arrangement, Type [Axis]
Lease Arrangement, Type [Domain]
Lease Arrangement, Type [Domain]
Laboratory and office space
Laboratory And Office Space [Member]
Represents information pertaining to laboratory and office space member.
Laboratory And Office Space Agreement Amendment April 2015
Laboratory And Office Space Agreement Amendment April2015 [Member]
Represents information pertaining to laboratory and office space agreement that was amended in April 2015.
Balance Sheet Location [Axis]
Balance Sheet Location [Axis]
Balance Sheet Location [Domain]
Balance Sheet Location [Domain]
Restricted cash and other deposits
Restricted Cash And Other Deposits [Member]
Represents inforamtion pertaining to restricted cash and other deposits member.
Accrued expenses
Accounts Payable and Accrued Liabilities [Member]
Credit Facility [Axis]
Credit Facility [Axis]
Credit Facility [Domain]
Credit Facility [Domain]
Letter of Credit
Letter of Credit [Member]
Statement [Line Items]
Statement [Line Items]
Tenant improvement allowance
Payments for (Proceeds from) Tenant Allowance
Letter of credit
Line of Credit Facility, Maximum Borrowing Capacity
Area exchanged (in square feet)
Area of Real Estate Property
Sublease income recorded as a reduction of lease expense
Operating Leases, Rent Expense, Sublease Rentals
Deferred rent and lease incentive liability
Deferred Rent And Lease Incentive Liability
This element represents both current and non current costs incurred by the lessor that are (a) costs to originate a lease incurred in transactions with independent third parties that (i) result directly from and are essential to acquire that lease and (ii) would not have been incurred had that leasing transaction not occurred and (b) certain costs directly related to specified activities performed by the lessor for that lease and includes the deferred charge for an incentive or inducement granted by a lessor to a lessee, in order to motivate the lessee to enter the lease agreement, which incentive or inducement is to be recognized as a reduction of rental revenue over the lease term.
Current portion of deferred rent and lease incentive
Accrued Rent And Lease Incentive Payable Current
" Carrying value as of the balance sheet date of obligations incurred through that date and payable for contractual rent under lease arrangements and an incentive or inducement contractually stipulated between parties to a lease whereby the lessor has committed to provide the entity (lessee) with a cash payment as inducement to enter the lease. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer)."
Rent expense, net of sublease payments
Operating Leases, Rent Expense, Net
Statement of Comprehensive Income [Abstract]
Grant and collaboration revenue
Revenues
Operating expenses:
Cost of Revenue [Abstract]
Research and development
Research and Development Expense
General and administrative
General and Administrative Expense
Total operating expenses
Operating Expenses
Loss from operations
Operating Income (Loss)
Investment income
Investment Income, Net
Foreign currency transaction gain (loss), net
Foreign Currency Transaction Gain (Loss), before Tax
Interest expense
Interest Expense
Other expense, net
Other Nonoperating Income (Expense)
Net loss
Other comprehensive loss:
Other Comprehensive Income (Loss), Tax [Abstract]
Foreign currency translation adjustment
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax
Unrealized gain (loss) on securities
Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Accretion of redeemable convertible preferred stock
Temporary Equity, Dividends, Adjustment
Net loss attributable to common stockholders
Net Income (Loss) Available to Common Stockholders, Basic
Net loss per share attributable to common stockholders
Earnings Per Share, Basic and Diluted [Abstract]
Basic and diluted (in dollars per share)
Earnings Per Share, Basic and Diluted
Weighted average common shares outstanding
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Basic and diluted (in shares)
Weighted Average Number of Shares Outstanding, Basic and Diluted
Related Party Transactions [Abstract]
Schedule of Related Party Transactions, by Related Party [Table]
Schedule of Related Party Transactions, by Related Party [Table]
Conversion of Series B Preferred
Series B Redeemable Convertible Preferred Stock [Member]
Represents information pertaining to series B redeemable convertible preferred stock.
Conversion of Series D Preferred
Series D Redeemable Convertible Preferred Stock [Member]
Represents information pertaining to series D redeemable convertible preferred stock.
Related Party [Axis]
Related Party [Axis]
Related Party [Domain]
Related Party [Domain]
Landlord
Landlord [Member]
Represents information pertaining to landlord member.
Founder
Founder [Member]
Represents information pertaining to founder member.
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Issued (in shares)
Temporary Equity, Shares Issued
Share price (in dollars per share)
Shares Issued, Price Per Share
Convertible preferred stock, par value (in dollars per share)
Temporary Equity, Par or Stated Value Per Share
Total proceeds
Proceeds from Issuance of Convertible Preferred Stock
Bridge loan
Bridge Loan
Expenses for consulting services
Related Party Transaction, Amounts of Transaction
Goodwill and Intangible Assets Disclosure [Abstract]
Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table]
Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table]
Type of Arrangement and Non-arrangement Transactions [Axis]
Type of Arrangement and Non-arrangement Transactions [Axis]
Arrangements and Non-arrangement Transactions [Domain]
Arrangements and Non-arrangement Transactions [Domain]
MIT
Exclusive Patent License Agreement With Massachusetts Institute Of Technology [Member]
Represents information pertaining to Exclusive patent license agreement with Massachusetts Institute of Technology.
"
Minimum
Minimum [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percentage of sublicense income
Percentage Of Sublicense Income
Represents information pertaining to percentage of sublicense income.
Payment amount upon achievement of defined clinical milestones
Payment Amount Upon Achievement Of Defined Clinical Milestones
Represents information pertaining to payment amount upon achievement of defined clinical milestones.
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
401(k) Savings Plan
Pension and Other Postretirement Benefits Disclosure [Text Block]
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Plan Name [Axis]
Plan Name [Axis]
Plan Name [Domain]
Plan Name [Domain]
2008 Plan
Stock Incentive Plan2008 [Member]
Represents the information pertaining to the 2008 stock incentive plan, which provides for the granting of stock based awards to employees, directors, and consultants under terms and provisions established by the board of directors.
Award Type [Axis]
Award Type [Axis]
Equity Award [Domain]
Equity Award [Domain]
Shares available for future stock incentive awards
Stock Compensation Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Risk-free interest rate
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Expected dividend yield
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected life
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Expected volatility
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Weighted-average fair value of common stock (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Weighted Average Fair Value
Weighed-average fair value relating to the share-based payment award.
Revenue Recognition [Abstract]
Sanofi
Sanofi Collaboration Agreement [Member]
Represents information pertaining to collaboration agreement with Sanofi.
Aggregate payments under Sanofi Agreement
Aggregate Amount Of Upfront And Milestone Based Payments
Represents information pertaining to aggregate amount of upfront and milestone based payments.
Deferred revenue expected to be recognized within the termination period
Deferred Revenue
Depreciation expense
Schedule of Research and Development Arrangement, Contract to Perform for Others [Table]
Schedule of Research and Development Arrangement, Contract to Perform for Others [Table]
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Minpromtorg
Russian Ministry Of Industry And Trade Grant Agreement [Member]
Represents information pertaining to Russian Ministry of industry and trade grant agreement.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Aggregate amount of grant
Grants From Entities Amount Of Grant Award
Represents information pertaining to aggregate amount of grant.
Repayment of funds
Repayment of Grant funding received
The cash outflow of grant funding received
Penalty fee, as percent of contract value
Penalty Fee,Percentage Of Contract Value
Represents information pertaining to penalty fee as percent of contract value.
Penalty fee
Penalty Fee Amount
Represents information pertaining to penalty fee.
Period to audit expenditure incurred
Period To Audit Expenditure Incurred
Represents information pertaining to period to audit expenditure incurred.
Contingently repayable grant funding
Revenue recognized
Revenue from Grants
Investments, Debt and Equity Securities [Abstract]
Number of positions in an unrealized loss position, less than 12 months
Available-for-sale, Securities in Unrealized Loss Positions, Qualitative Disclosure, Number of Positions, Less than One Year
Number of investment positions
Available-for-sale, Securities in Unrealized Loss Positions, Qualitative Disclosure, Number of Positions
Other-than-temporary impairments
Other than Temporary Impairment Losses, Investments, Available-for-sale Securities
Fair Value Disclosures [Abstract]
Fair Value Measurements, Recurring and Nonrecurring [Table]
Fair Value Measurements, Recurring and Nonrecurring [Table]
Long-term Debt, Type [Axis]
Long-term Debt, Type [Axis]
Long-term Debt, Type [Domain]
Long-term Debt, Type [Domain]
Convertible Debt
Convertible Debt [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash and cash equivalents collateralized by government securities (as a percent)
Cash And Cash Equivalents Collateralized By Government Securities, Value Of Collateral, Percent Of Fair Value
Cash And Cash Equivalents Collateralized By Government Securities, Value Of Collateral, Percent Of Fair Value
Average maturity for US Treasury obligations, term
Investments Maturity Period
Represents information pertaining to US treasury obligations in investments maturity period.
Warrants issued for purchase of stock (in shares)
Stockholders' Equity Note [Abstract]
Schedule of authorized shares of common stock reserved for future issuance
Schedule of Stock by Class [Table Text Block]
3SBio License
License Agreement With Shenyang Sunshine Pharmaceutical Company Limited [Member]
Represents information pertaining to License agreement with Shenyang Sunshine Pharmaceutical co., ltd.
Period for commercialization of product
Period For Commercialization Of Product
Represents information pertaining to period for commercialization of product.
Aggregate amount of upfront and milestone based payments
Aggregate amount for future payments upon achievement of clinical and regulatory approval milestones for products containing SVP technology
Aggregate Amount For Future Payments Upon Achievement Of Clinical And Regulatory Approval Milestones For Products Containing Svp Technology
Represents information pertaining to aggregate amount for future payments upon achievement of clinical and regulatory approval milestones for product containing SVP technology.
Aggregate amount for future payments upon achievement of clinical and regulatory approval milestones for products without SVP technology
Aggregate Amount For Future Payments Upon Achievement Of Clinical And Regulatory Approval Milestones For Products Without Svp Technology
Represents information pertaining to aggregate amount for future payments upon achievement of clinical and regulatory approval milestones for product without SVP technology.
Period for prior written notice to terminate license
Period For Prior Written Notice To Terminate License
Represents information pertaining to period for prior written notice to terminate license.
Votes per share of common stock
Votes Per Share of Common Stock
Votes Per Share of Common Stock
Common stock dividend
Dividends, Common Stock
Schedule of Stock by Class [Table]
Schedule of Stock by Class [Table]
Conversion of Series A Preferred
Seriesa Redeemable Convertible Preferred Stock [Member]
Represents information pertaining to series A redeemable convertible preferred stock.
Conversion of Series C Preferred
Series C Redeemable Convertible Preferred Stock [Member]
Represents information pertaining to series C redeemable convertible preferred stock.
Conversion of Series SRN Preferred
Series Srn Redeemable Convertible Preferred Stock [Member]
Represents information pertaining to series SRN redeemable convertible preferred stock.
Stock options to purchase common stock
Employee Stock Option [Member]
Exercise of common warrants
Warrant [Member]
Class of Stock [Line Items]
Class of Stock [Line Items]
Common stock reserved for future issuance (in shares)
Common Stock, Capital Shares Reserved for Future Issuance
Schedule of Weighted Average Assumptions Used for Stock Option Grants
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Summary of Activity
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]
Summary of Restricted Stock Award Activity
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block]
Stock-Based Compensation Expense Related to Stock Options and Restricted Common Stock
Schedule of Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Table Text Block]
Earnings Per Share [Abstract]
Net Loss Per Share
Earnings Per Share [Text Block]
Financial Assets and Liabilities Measured and Carried at Fair Value
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Computation of Basic and Diluted Net Loss Per Share
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Potential Common Shares Issuable Upon Conversion of Warrants to Purchase Common Stock and Stock Options Excluded from Computation of Diluted Weighted Average Shares Outstanding
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Common Stock
Stockholders' Equity Note Disclosure [Text Block]
Debt
Debt Disclosure [Text Block]
Line of Credit Facility [Table]
Line of Credit Facility [Table]
Term Loan
Term Loan [Member]
Represents information pertaining to term loan member.
Line of Credit Facility [Line Items]
Line of Credit Facility [Line Items]
Year ended December 31,
Long-term Debt, Fiscal Year Maturity [Abstract]
2016
Long-term Debt, Maturities, Repayments of Principal in Next Twelve Months
2017
Long-term Debt, Maturities, Repayments of Principal in Year Two
2018
Long-term Debt, Maturities, Repayments of Principal in Year Three
2019
Long-term Debt, Maturities, Repayments of Principal in Year Four
Total debt payments
Long-term Debt, Gross
Less: Amount representing interest
Debt Instrument Interest Portion
The interest portion of gross outstanding debt.
Less: Debt discount and deferred charges
Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net
Less: Current portion of issuance costs
Debt Issuance Costs, Current, Net
Loans payable, net of current portion
Long-term Debt, Excluding Current Maturities
Related-Party Transactions
Related Party Transactions Disclosure [Text Block]
The Plan and the 2016 Plan
The 2008 Plan And The 2016 Plan [Member]
The 2008 Plan And The 2016 Plan [Member]
Employee
Non‑Employee
Non Employee Stock Option [Member]
An arrangement whereby a non-employee is entitled to receive in the future, subject to vesting and other restrictions, a number of shares in the entity at a specified price, as defined in the agreement.
Number of Options
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Beginning balance (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Granted (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Exercised (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Forfeited (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period
Ending balance (in shares)
Vested (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Number of Shares
Vested and expected to vest (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Weighted-average exercise price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Beginning balance (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Granted (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Exercised (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Forfeited (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Ending balance (in dollars per share)
Vested (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Weighted Average Exercise Price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Weighted Average Exercise Price
Vested and expected to vest (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Weighted-average remaining contractual term
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term [Abstract]
n/a
Outstanding (period)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Vested (period)
Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Weighted Average Remaining Contractual Term
Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Weighted Average Remaining Contractual Term
Vested and expected to vest (period)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Aggregate intrinsic value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value [Abstract]
n/a
Outstanding
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Vested
Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Intrinsic Value
Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Intrinsic Value
Vested and expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
JDRF
Juvenile Diabetes Research Foundation Grant Agreement [Member]
Represents information pertaining to Juvenile Diabetes research foundation grant agreement.
Initial payment for first indication
Initial Payment For First Indication
Represents information pertaining to initial payment for first indication.
Additional payment for preclinical research for each indication
Additional Payment For Preclinical Research For Each Indication
Represents information pertaining to additional payment for preclinical research for each indication.
Additional payment upon attaining first milestone for celiac disease indication
Initial period to complete research obligations
Initial Period To Complete Research Obligations
Initial Period To Complete Research Obligations
Grant and collaboration revenue
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Schedule of Cash and Cash Equivalents [Table]
Schedule of Cash and Cash Equivalents [Table]
Geographical [Axis]
Geographical [Axis]
Geographical [Domain]
Geographical [Domain]
Russian subsidiary
RUSSIAN FEDERATION
Cash and Cash Equivalents [Line Items]
Cash and Cash Equivalents [Line Items]
Unrestricted cash held by subsidiary
Cash
Fair Value Measurements
Fair Value Disclosures [Text Block]
Accounting Policies [Abstract]
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Table]
Property, Plant and Equipment, Type [Axis]
Property, Plant and Equipment, Type [Axis]
Property, Plant and Equipment, Type [Domain]
Property, Plant and Equipment, Type [Domain]
Furniture
Furniture and Fixtures [Member]
Equipment
Equipment [Member]
Computer and office equipment
Office Equipment [Member]
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Estimated useful life
Property, Plant and Equipment, Useful Life
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table]
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table]
Income Statement Location [Axis]
Income Statement Location [Axis]
Income Statement Location [Domain]
Income Statement Location [Domain]
Research and development
Research And Development [Member]
Represents the information pertaining to research and development expenses included in the income statement.
General and administrative
General and Administrative Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total
Future Minimum Payments on the Term Loans
Schedule of Maturities of Long-term Debt [Table Text Block]
Fair Value
Available-for-sale Securities, Debt Maturities, Fair Value, Fiscal Year Maturity [Abstract]
Less than one year
Available-for-sale Securities, Debt Maturities, Next Twelve Months, Fair Value
Amortized Cost
Available-for-sale Securities, Debt Maturities, Amortized Cost Basis, Fiscal Year Maturity [Abstract]
Less than one year
Available-for-sale Securities, Debt Maturities, Next Twelve Months, Amortized Cost Basis
Scenario [Axis]
Scenario [Axis]
Scenario, Unspecified [Domain]
Scenario, Unspecified [Domain]
Prepaid prior to first anniversary
Term Loan Prepaid Prior To First Anniversary [Member]
Represents information pertaining to prepayment of term loan prior to first anniversary.
Prepaid prior to first anniversary but before second
Term Loan Prepaid After First Anniversary But Before Second Anniversary [Member]
Represents information pertaining to prepayment of term loan after first anniversary but prior to second anniversary.
Prepaid after second anniversary
Term Loan Prepaid After Second Anniversary [Member]
Represents information pertaining to prepayment of term loan after second anniversary.
Number of lenders
Number Of Lenders
Represents the number of lenders.
Loan and security agreement, maximum borrowing capacity
Borrowings on loan and security agreement
Proceeds from Lines of Credit
Outstanding principal balance under Term Loans
Long-term Line of Credit
Interest rate of Term Loans
Line of Credit Facility, Interest Rate During Period
Number of monthly installments
Term Loan Number Of Monthly Payments
The number of monthly payments required on the term loan.
Prepayment fee (as a percent)
Early Extinguishment Of Debt, Prepayment Fee Percentage
Percentage of fee payable on early extinguishment of debt.
Final payment fee (as a percent)
Final Payment Fee Percentage
Percentage of final fee payment payable on aggregate principal amounts borrowed.
Total final payment fee
Final Payment Fee
Final fee payment on the aggregate principal amounts borrowed payable.
Initial grant date fair value of warrants
Warrants, Grant Date Fair Value
Represents the initial grant date fair value of the warrants.
Interest expense
Realized gains or losses on sale of investments
Realized Investment Gains (Losses)
Restricted Stock Units (RSUs)
Restricted Stock Units (RSUs) [Member]
Number of shares issued upon the early exercise of stock options
Number of shares issued
Stock Issued During Period, Shares, New Issues
Payments received for the purchase of restricted shares
Proceeds from Issuance of Common Stock
Outstanding liability (less than)
Liability Under Repurchase Provision Agreement
The outstanding liability under the terms of repurchase provision agreement, for the repurchase of restricted stock.
Total fair value of restricted shares (less than)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value
Unrecognized compensation expense related to unvested employee stock options (less than)
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Share-based Awards Other than Options
Weighted average period for recognizing, unrecognized compensation expense
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition
Laboratory equipment
Laboratory Equipment [Member]
Represents information pertaining to laboratory equipment.
Computer equipment and software
Computer Equipment [Member]
Leasehold improvements
Leasehold Improvements [Member]
Furniture and fixtures
Office equipment
P,P&E—Construction in process
Construction in Progress [Member]
Total property and equipment
Property, Plant and Equipment, Gross
Less accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Property and equipment, net
Property, Plant and Equipment, Net
Revenue Arrangements
Collaborative Arrangement Disclosure [Text Block]
Schedule of Available-for-sale Securities [Table]
Schedule of Available-for-sale Securities [Table]
Major Types of Debt and Equity Securities [Axis]
Major Types of Debt and Equity Securities [Axis]
Major Types of Debt and Equity Securities [Domain]
Major Types of Debt and Equity Securities [Domain]
U.S. Treasury securities
US Treasury Securities [Member]
Corporate bonds
Corporate Bond Securities [Member]
Schedule of Available-for-sale Securities [Line Items]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost
Available-for-sale Securities, Amortized Cost Basis
Gross Unrealized Gains
Available-for-sale Securities, Accumulated Gross Unrealized Gain, before Tax
Gross Unrealized Losses
Available-for-sale Securities, Accumulated Gross Unrealized Loss, before Tax
Estimated Fair Value
Available-for-sale Securities
Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table]
Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table]
Sale of Stock [Axis]
Sale of Stock [Axis]
Sale of Stock [Domain]
Sale of Stock [Domain]
IPO
IPO [Member]
Over-Allotment Option
Over-Allotment Option [Member]
Subsidiary, Sale of Stock [Line Items]
Subsidiary, Sale of Stock [Line Items]
Reverse stock split ratio
Stockholders' Equity Note, Stock Split, Conversion Ratio
Common stock issued and sold (in shares)
Net proceeds from initial public offering
Common stock issued for convertible preferred stock (in shares)
Convertible Preferred Stock, Shares Issued upon Conversion
Available-for-Sale Marketable Securities
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Technology License Agreements
Technology License Agreements [Text Block]
The entire disclosure for technology license agreements.
NIH
National Institutes Of Health Grant Agreement [Member]
Represents information pertaining to national institutes of health grant agreement.
First Grant
First Grant [Member]
Represents information pertaining to first grant under NIH.
Second Grant
Second Grant [Member]
Represents information pertaining to second grant under NIH.
Number of grants
Number Of Grants
Represents information pertaining to number of grants.
Temporary Equity Disclosure [Abstract]
Temporary Equity, by Class of Stock [Table]
Temporary Equity, by Class of Stock [Table]
Preferred stock
Temporary Equity [Line Items]
Convertible preferred stock, shares issued (in shares)
Additional shares issued (in shares)
Temporary Equity Stock Issued During Period Share New Issues
Represents information pertaining to temporary equity stock issued during period.
Price per share (in dollars per share)
Net proceeds
Proceeds from Issuance of Redeemable Convertible Preferred Stock
Conversion price (in dollars per share)
Temporary Equity Conversion Price Per Share
Represents information pertaining to temporary equity conversion price per share.
Carrying value of Series SRN Preferred
Temporary Equity, Carrying Amount, Attributable to Parent
Difference recorded in additional paid in capital
Adjustments to Additional Paid in Capital, Increase in Carrying Amount of Redeemable Preferred Stock
Gross proceeds
Proceeds From Issuance Of Redeemable Convertible Preferred Stock Gross
The gross cash inflow from issuance of callable preferred stock which is identified as being convertible to another type of financial security at the option of the issuer or the holder.
Issuance costs
Warrants to purchase common stock, percentage on preferred shares
Percentage Of Warrants To Purchase Common Stock
Represents information pertaining to percentage of warrants to purchase common stock on preferred shares.
Conversion of convertible stock upon listing (in shares)
Temporary Equity Conversion Of Convertible Stock Shares
Number of shares of convertible stock that was converted during the period.
Bill and Melinda Gates Foundation
Bill And Melinda Gates Foundation Grant Agreement [Member]
Represents information pertaining to Bill and Melinda gates foundation grant agreement.
Extended research term
Extended Research Term
Represents information pertaining to extended research term.
Payables and Accruals [Abstract]
Payroll
Accrued Salaries, Current
Legal
Accrued Professional Fees, Current
Bonus
Accrued Bonuses, Current
Accrued patent fees
Accrued Patent Fees Current
Carrying value as of the balance sheet date of patent fees.
Accrued external research and development costs
Accrued Research And Development Costs Current
Carrying value as of the balance sheet date of research and development costs.
Other
Other Accrued Liabilities, Current
Accrued expenses
Accrued Liabilities, Current
Accrued Expenses
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Summary of Accrued Expenses
Schedule of Accrued Liabilities [Table Text Block]
Preferred Stock
Temporary Equity Disclosure [Text Block]
The entire disclosure for temporary equity.
Statement of Financial Position [Abstract]
Statement [Table]
Statement [Table]
Series A redeemable convertible preferred stock
Series B redeemable convertible preferred stock
Series C redeemable convertible preferred stock
Series D redeemable convertible preferred stock
Series SRN redeemable convertible preferred stock
Series E redeemable convertible preferred stock
Convertible preferred stock, shares authorized
Temporary Equity, Shares Authorized
Convertible preferred stock, shares outstanding
Temporary Equity, Shares Outstanding
Preferred stock, par value (in dollars per share)
Preferred Stock, Par or Stated Value Per Share
Preferred stock, shares authorized
Preferred Stock, Shares Authorized
Preferred stock, shares issued
Preferred Stock, Shares Issued
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding
Common stock, par value (in dollars per share)
Common Stock, Par or Stated Value Per Share
Common stock, shares authorized
Common Stock, Shares Authorized
Common stock, shares issued
Common Stock, Shares, Issued
Common stock, shares outstanding
Common Stock, Shares, Outstanding
Principles of Consolidation
Consolidation, Policy [Policy Text Block]
Foreign Currency
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Segment Information
Segment Reporting, Policy [Policy Text Block]
Cash Equivalents and Short Term Investments
Cash Equivalents And Short Term Investments [Policy Text Block]
Disclosure of accounting policy for cash equivalents and short term investments.
Concentrations of Credit Risk and Off-Balance Sheet Risk
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Fair Value of Financial Instruments
Fair Value of Financial Instruments, Policy [Policy Text Block]
Property and Equipment
Property, Plant and Equipment, Policy [Policy Text Block]
Impairment of Long-Lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Debt Issuance Costs
Debt, Policy [Policy Text Block]
Revenue Recognition
Revenue Recognition, Policy [Policy Text Block]
Collaborative Revenue
Collaborative Arrangement, Accounting Policy [Policy Text Block]
Grant Agreements
Revenue Recognition Grant Revenue [Policy Text Block]
Disclosure of accounting policy for revenue recognition for revenue from grants.
Research and Development Costs
Research and Development Expense, Policy [Policy Text Block]
Clinical Trial Costs
Clinical Trial Costs [Policy Text Block]
Disclosure of accounting policy for clinical trial costs.
Income Taxes
Income Tax, Policy [Policy Text Block]
Warrants
Warrants [Policy Text Block]
Disclosure of accounting policy for warrants.
Stock-Based Compensation
Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block]
Comprehensive Loss
Comprehensive Income, Policy [Policy Text Block]
Net Loss Per Share
Earnings Per Share, Policy [Policy Text Block]
Deferred Rent
Deferred Rent [Policy Text Block]
Disclosure of accounting policy for deferred rent.
Contingent Liabilities
Contingent Liability Reserve Estimate, Policy [Policy Text Block]
Recent Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Concentration Risk [Table]
Concentration Risk [Table]
Currency [Axis]
Currency [Axis]
All Currencies [Domain]
All Currencies [Domain]
Rubles
Russia, Rubles
U S dollars
United States of America, Dollars
Concentration Risk [Line Items]
Concentration Risk [Line Items]
Cash maintained in Russian bank accounts
Schedule of Share-based Goods and Nonemployee Services Transaction [Table]
Schedule of Share-based Goods and Nonemployee Services Transaction [Table]
Non-employee stock options
Share-based Goods and Nonemployee Services Transaction [Line Items]
Share-based Goods and Nonemployee Services Transaction [Line Items]
Risk‑free interest rate
Share-based Goods and Nonemployee Services Transaction, Valuation Method, Risk Free Interest Rate
Expected dividend yield
Share-based Goods and Nonemployee Services Transaction, Valuation Method, Expected Dividend Rate
Expected life (in years)
Share-based Goods and Nonemployee Services Transaction, Valuation Method, Expected Term
Expected volatility
Share-based Goods and Nonemployee Services Transaction, Valuation Method, Expected Volatility Rate
Summary of Available-for-Sale Marketable Securities
Schedule of Available-for-sale Securities Reconciliation [Table Text Block]
Schedule of Fair Values and Amortized Cost of Marketable Debt Securities by Contractual Maturity
Investments Classified by Contractual Maturity Date [Table Text Block]
The 2008 Plan and the 2016 Plan
Shares
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Beginning balance (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Issued (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period
Vested (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period
Ending balance (in shares)
Weighted-average exercise price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Beginning balance (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Issued (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Vested (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Ending balance (in dollars per share)
Number of operating segments
Number of Operating Segments
Document and Entity Information
Document Type
Document Type
Amendment Flag
Amendment Flag
Document and Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Filer Category
Entity Filer Category
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Measurement Frequency [Axis]
Measurement Frequency [Axis]
Fair Value, Measurement Frequency [Domain]
Fair Value, Measurement Frequency [Domain]
Recurring
Fair Value, Measurements, Recurring [Member]
Cash and Cash Equivalents [Axis]
Cash and Cash Equivalents [Axis]
Cash and Cash Equivalents [Domain]
Cash and Cash Equivalents [Domain]
Money market funds, included in cash equivalents
Money Market Funds [Member]
Tri-party repurchase agreements, included in cash equivalents
Repurchase Agreements [Member]
US Treasury obligations
Corporate bonds, included in investments
Fair Value, Hierarchy [Axis]
Fair Value, Hierarchy [Axis]
Fair Value Hierarchy [Domain]
Fair Value Hierarchy [Domain]
(level 1)
Fair Value, Inputs, Level 1 [Member]
(level 2)
Fair Value, Inputs, Level 2 [Member]
(level 3)
Fair Value, Inputs, Level 3 [Member]
Cash equivalents
Cash and Cash Equivalents, Fair Value Disclosure
Investments
Investments, Fair Value Disclosure
Warrants to purchase redeemable convertible preferred stock, included in other long term liabilities
Financial and Nonfinancial Liabilities, Fair Value Disclosure
Schedule of Future Minimum Lease Payments as Amended by Lease Amendment
Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block]
Stock Incentive Plans
Disclosure of Compensation Related Costs, Share-based Payments [Text Block]
Convertible preferred stock underlying share fair value price (in dollars per share)
Convertible Preferred Stock Warrants Fair Value Of Underlying Common Shares
The price per share of the fair value of the underlying common shares of convertible preferred stock warrants.
Skolkovao
Russia Vased Development Fund Of New Technologies Development And Commercialization Center Grant Agreement [Member]
Represents information pertaining to russi vased development fund of new technologies development and commercialization center grant agreement.
Percentage of estimated cost of research plan
Percentage Of Estimated Cost Of Research Plan
Represents information pertaining to percentage of estimated cost of research plan.
Remaining percentage contributed by the entity
Remaining Percentage Contributed By The Entity
Represents information pertaining to remaining percentage contributed by the entity.
MEE
License Agreement With Massachusetts Eye And Ear Infirmary And Schepens Eye Research Institute Inc. [Member]
Represents information pertaining to License agreement with Massachusetts Eye and Ear Infirmary and The Schepens Eye Research Institute, Inc.
Minimum number of products marketed and sold
Number Of Products Marketed And Sold
Represents the number of products the Company has agreed to market and sell for each target sequence for which the Company exercised its option as soon as reasonably practicable.
Payment under development milestone method
Development Milestone Method, Amount Paid
The amount of consideration paid during the period for the development milestone or milestones.
Payment under sales milestone method
Sales Milestone Method, Amount Paid
The amount of consideration paid during the period for the sales milestone or milestones.
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Antidilutive Securities [Axis]
Antidilutive Securities [Axis]
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name [Domain]
Redeemable convertible preferred stock
Redeemable Convertible Preferred Stock [Member]
Stock warrants to purchase common stock
Potential common shares
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Assets
Assets [Abstract]
Current assets:
Assets, Current [Abstract]
Cash and cash equivalents
Short term deposits and investments
Short-term Investments
Restricted cash
Restricted Cash and Cash Equivalents, Current
Accounts receivable
Accounts Receivable, Net, Current
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Total current assets
Assets, Current
Property and equipment, net
Restricted cash and other deposits
Restricted Cash and Investments, Noncurrent
Other assets
Other Assets, Noncurrent
Total assets
Assets
Liabilities, redeemable convertible preferred stock, and stockholders’ equity (deficit)
Liabilities and Equity [Abstract]
Current liabilities:
Liabilities, Current [Abstract]
Accounts payable
Accounts Payable, Current
Accrued expenses
Loans payable, current portion
Loans Payable, Current
Deferred revenue, current portion
Deferred Revenue, Current
Contingently repayable grant funding
Contingently Repayable Grant Funding Current
Represents information pertaining to current contingently repayable grant funding.
Total current liabilities
Liabilities, Current
Non‑current liabilities:
Other Liabilities, Noncurrent [Abstract]
Deferred rent and lease incentive
Deferred Rent Credit, Noncurrent
Loans payable, net of current portion
Loans Payable, Noncurrent
Deferred revenue, net of current portion
Deferred Revenue, Noncurrent
Other long‑term liabilities
Other Liabilities, Noncurrent
Total liabilities
Liabilities
Commitments and contingencies (Notes 8 and 13)
Commitments and Contingencies
Series A redeemable convertible preferred stock, $0.0001 par value; 0 and 2,589,868 shares authorized; 0 and 2,589,868 shares issued and outstanding; as of September 30, 2016 and December 31, 2015 respectively.
Series B redeemable convertible preferred stock, $0.0001 par value; 0 and 7,437,325 shares authorized; 0 and 7,437,325 shares issued and outstanding; as of September 30, 2016 and December 31, 2015 respectively.
Series C redeemable convertible preferred stock, $0.0001 par value; 0 and 5,000,002 shares authorized; 0 and 5,000,002 shares issued and outstanding; as of September 30, 2016 and December 31, 2015 respectively.
Series D redeemable convertible preferred stock, $0.0001 par value; 0 and 8,166,662 shares authorized; 0 and 8,099,994 shares issued and outstanding; as of September 30, 2016 and December 31, 2015 respectively.
Series SRN redeemable convertible preferred stock, $0.0001 par value; 0 and 5,611,112 shares authorized; 0 and 2,111,109 shares issued and outstanding; as of September 30, 2016 and December 31, 2015 respectively.
Series E redeemable convertible preferred stock, $0.0001 par value; 0 and 9,030,654 shares authorized; 0 and 8,888,888 shares issued and outstanding; as of September 30, 2016 and December 31, 2015 respectively.
Total redeemable convertible preferred stock
Stockholders’ equity (deficit):
Stockholders' Equity Attributable to Parent [Abstract]
Preferred stock, $0.0001 par value; 10,000,000 and 0 shares authorized; 0 shares issued and outstanding at September 30, 2016 and December 31, 2015, respectively.
Preferred Stock, Value, Issued
Common stock, $0.0001 par value; 200,000,000 and 62,164,377 shares authorized at September 30, 2016 and December 31, 2015 respectively; 18,190,180 and 2,180,976 shares issued, 18,188,313 and 2,173,399 shares outstanding as of September 30, 2016 and December 31, 2015, respectively.
Common Stock, Value, Issued
Additional paid-in capital
Additional Paid in Capital
Accumulated deficit
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax
Total stockholders’ equity (deficit)
Stockholders' Equity Attributable to Parent
Total liabilities, redeemable convertible preferred stock and stockholders’ equity
Liabilities and Equity
Other Research And Collaboration Agreements
Other Research And Collaboration Agreements [Member]
Represents information pertaining to other research and collaboration agreements.
Statement of Stockholders' Equity [Abstract]
Additional paid-In Capital
Additional Paid-in Capital [Member]
Accumulated deficit
Retained Earnings [Member]
Accumulated other comprehensive loss
AOCI Attributable to Parent [Member]
Increase (Decrease) in Temporary Equity [Roll Forward]
Increase (Decrease) in Temporary Equity [Roll Forward]
Beginning balance (in shares)
Beginning balance
Accretion of preferred stock to redemption value
Conversion of convertible stock upon listing
Temporary Equity Conversion Of Convertible Stock Value
Value of conversion of convertible stock during the period.
Ending balance (in shares)
Ending balance
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Beginning balance (in shares)
Beginning balance
Vesting of restricted common stock (in shares)
Stock Vested During Period Share Restricted Common Stock
Represents the total number of shares vested during the period as a result of Restricted Common Stock.
Vesting of restricted common stock
Stock Vested During Period Value Restricted Common Stock
Represents the aggregate value of stock related to Restricted Common Stock vested during the period.
Issuance of common stock upon exercise of options (in shares)
Issuance of common stock upon exercise of options
Stock Issued During Period, Value, Stock Options Exercised
Stock‑based compensation expense
Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition
Accretion of preferred stock to redemption value
Stockholders Equity Accretion to Redemption Value
Represents the value of accretion of temporary equity to redemption value during the period.
Exercise of common warrants (in shares)
Stock Issued During Period Shares Warrants Exercised
Number of warrants exercised during the current period.
Exercise of common warrants
Stock Issued During The Period, Value, Warrants Exercised
Stock Issued During The Period, Value, Warrants Exercised
Conversion of convertible stock upon listing (in shares)
Stock Issued During Period, Shares, Conversion of Convertible Securities
Conversion of convertible stock upon listing
Stock Issued During Period, Value, Conversion of Convertible Securities
Issuance of common stock, Initial public offering net of issuance costs
Stock Issued During Period, Value, New Issues
Conversion of preferred stock warrants into warrants for the purchase of common stock
Stock Issued During Period Value Conversion Preferred Stock Warrants
The gross value of stock issued during the period upon the conversion of preferred stock warrants.
Currency translation adjustment
Unrealized gains (losses) on securities
Ending balance (in shares)
Ending balance
Subsequent Events [Abstract]
Subsequent Events
Subsequent Events [Text Block]
Vesting [Axis]
Vesting [Axis]
Vesting [Domain]
Vesting [Domain]
Tranche One
Share-based Compensation Award, Tranche One [Member]
Tranche Two
Share-based Compensation Award, Tranche Two [Member]
2016 Plan
Stock Incentive Plan2016 [Member]
Represents the information pertaining to the 2016 stock incentive plan, which provides for the granting of stock based awards to employees, directors, and consultants under terms and provisions established by the board of directors.
ESPP
Employee Stock Purchase Plan2016 [Member]
Represent information pertaining to the 2016 Employee Stock Purchase Plan.
Number of shares authorized for grants
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Exercise price of options on common stock (as a percent)
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent
Employees holding voting rights of all classes of stock (as a percent)
Share-based Compensation Arrangement By Share-based Payment Award, Voting Rights of Common Stock, Holding Percentage
Represents the percentage of voting rights of all classes of stock held by the employees.
Award vesting term
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
Award expiration term
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period
Forfeitures rate
Share-based Compensation Arrangement By Share-based Payment Award Forfeitures Rate
Represents the percentage of forfeitures rate of the stock options based on the historical trends.
Maximum percentage of shares available may increase each year
Employee Stock Purchase Plan Maximum Percentage Of Shares Reserved Based On Shares Outstanding
The maximum percentage increase in the shares reserved for future issuance each year based on the number of common stock outstanding at the last day of the year.
Weighted-average fair value of stock options (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Aggregate intrinsic value
Unrecognized compensation expense related to unvested employee stock options
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options
Non‑employee stock‑based compensation expense
Non Employee Service Share-based Compensation, Nonvested Awards, Compensation Expenses, Stock Options
Represents Non-employee stock-based compensation expense
Unrecognized compensation expense related to unvested non-employee stock options
Non Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options
Unrecognized cost of unvested options awarded to non-employees as compensation."
Year ended December 31,
Operating Leases, Future Minimum Payments Due, Fiscal Year Maturity [Abstract]
2016
Operating Leases, Future Minimum Payments, Remainder of Fiscal Year
2017
Operating Leases, Future Minimum Payments, Due in Two Years
2018
Operating Leases, Future Minimum Payments, Due in Three Years
2019
Operating Leases, Future Minimum Payments, Due in Four Years
2020
Operating Leases, Future Minimum Payments, Due in Five Years
Total minimum lease payments
Operating Leases, Future Minimum Payments Due
Schedule of Property and Equipment
Property, Plant and Equipment [Table Text Block]
Numerator:
Net Income (Loss) Available to Common Stockholders, Basic [Abstract]
Net (loss)
Less: accretion on preferred stock
Denominator:
Weighted‑average common shares outstanding—basic and diluted (in shares)
Net loss per share attributable to common stockholders—basic and diluted (in dollars per share)
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]