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Increase (Decrease) in Contract with Customer, Liability Long-term restricted cash Restricted Cash, Noncurrent Cashless warrant exercise Noncash Or Part Noncash, Warrant Exercises Noncash Or Part Noncash, Warrant Exercises License and option agreement, written day notice period before cancellation License And Option Agreement, Written Day Notice Period Before Cancellation License And Option Agreement, Written Day Notice Period Before Cancellation Remaining performance obligation Revenue, Remaining Performance Obligation, Amount Development milestone License And Option Agreement, Development Milestone License And Option Agreement, Development Milestone Weighted-average exercise price Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Sarepta Therapeutics, Inc. 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[Member] Share price (in dollars per share) Sale of Stock, Price Per Share Russian subsidiary RUSSIAN FEDERATION Subsequent Events Subsequent Events [Text Block] Total comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Reserved for issuance (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Reserved For Issuance, Weighted Average Grant Date Fair Value Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Reserved For Issuance, Weighted Average Grant Date Fair Value Contract liabilities, beginning of period Contract liabilities, end of period Contract with Customer, Liability Net cash provided by financing activities Net Cash Provided by (Used in) Financing Activities Weighted average common shares outstanding: Denominator: Weighted Average Number of Shares Outstanding, Diluted [Abstract] Related Party Transaction [Line Items] Related Party Transaction [Line Items] Award vesting term Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period Total tax expense, inclusive of estimated penalties and interest Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense AskBio License AskBio License [Member] AskBio License [Member] Fair Value Measurements Fair Value Disclosures [Text Block] Accounts payable Accounts Payable, Current Summary of Assets Measured at Fair Value on a Recurring Basis Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Accumulated other comprehensive loss AOCI Attributable to Parent [Member] Other assets Other Assets Common stock, shares outstanding (in shares) Beginning balance (in shares) Ending balance (in shares) Common Stock, Shares, Outstanding Financial Instruments [Domain] Financial Instruments [Domain] Other comprehensive income (loss): Other Comprehensive Income (Loss), Tax [Abstract] Debt instrument, additional accrued interest in the event of default Debt Instrument, Additional Accrued Interest In the Event Of Default Debt Instrument, Additional Accrued Interest In the Event Of Default Potential common shares Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Cyrus Biotechnology, Inc. Cyrus Biotechnology, Inc. [Member] Cyrus Biotechnology, Inc. Number of Options Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] Lease Arrangement [Domain] Lease Arrangement [Domain] [Domain] for Lease Arrangement [Axis] Collaboration and licensing Accrued Collaboration and Licensing Accrued Collaboration and Licensing Cash flows from investing activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Lessee-paid construction costs Total lease cost Lease, Cost Schedule of Property and Equipment Property, Plant and Equipment [Table Text Block] Income Statement Location [Domain] Income Statement Location [Domain] At-The-Market Offering At-The-Market Offering [Member] At-The-Market Offering [Member] Debt Securities, Available-for-sale [Table] Debt Securities, Available-for-sale [Table] License Agreement For Pompe Disease License Agreement For Pompe Disease [Member] License Agreement For Pompe Disease [Member] 2020 Term Loans 2020 Term Loans [Member] 2020 Term Loans Warrant issued Warrant Issued Warrant Issued Class of warrant or right, expiration period Class Of Warrant Or Right, Expiration Period Class Of Warrant Or Right, Expiration Period Property and equipment, net Property and equipment, net Property, Plant and Equipment, Net Property and Equipment Property, Plant and Equipment Disclosure [Text Block] Total operating expenses Operating expenses Operating Expenses License and option agreement, payments made relative to calculated premium paid for initial equity investment made under the purchase agreement License And Option Agreement, Calculated Premium Paid For Equity Investment Under Purchase Agreement License And Option Agreement, Calculated Premium Paid For Equity Investment Under Purchase Agreement Issuance of common stock upon exercise of pre-funded warrants Shares Issued During Period, Value, Pre-Funded Warrants Shares Issued During Period, Value, Pre-Funded Warrants Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table] Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table] Repayments of principal on outstanding debt Repayments of Long-term Debt Earnings Per Share [Abstract] Collaborative Arrangement Collaborative Arrangement [Member] Total property and equipment Property, Plant and Equipment, Gross Document Quarterly Report Document Quarterly Report 3SBio License License Agreement With Shenyang Sunshine Pharmaceutical Company Limited [Member] Represents information pertaining to License agreement with Shenyang Sunshine Pharmaceutical co., ltd. 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Outstanding, Term Loan payable, net of current portion Long-term Debt, Excluding Current Maturities Liabilities: Liabilities, Fair Value Disclosure [Abstract] Schedule of Related Party Transactions, by Related Party [Table] Schedule of Related Party Transactions, by Related Party [Table] Issuance of common stock through at-the-market offering, net Stock Issued During Period, Value, Other Stock‑based compensation expense Total stock-based compensation expense Stock-based compensation expense Share-based Payment Arrangement, Expense Option term License And Option Agreement, Option Term License And Option Agreement, Option Term Sale of stock, percentage of ten-day volume weighted average price of common stock Sale of Stock, Percentage Of Ten-Day Volume Weighted Average Price Of Common Stock Sale of Stock, Percentage Of Ten-Day Volume Weighted Average Price Of Common Stock Risk-free interest rate Measurement Input, Risk Free Interest Rate [Member] Net loss per share: Earnings Per Share, 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and restricted cash at beginning of period Cash, cash equivalents, and restricted cash at end of period Total cash, cash equivalents, and restricted cash Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Sale of stock, number of shares issued in transaction (in shares) Sale of Stock, Number of Shares Issued in Transaction Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Reclassification of warrant liability to equity upon exercise of warrants Noncash Or Part Noncash, Reclassification Of Warrant Liability To Equity Noncash Or Part Noncash, Reclassification Of Warrant Liability To Equity Statement of Comprehensive Income [Abstract] Statement of Comprehensive Income [Abstract] Income taxes payable Taxes Payable, Current Current assets: Assets, Current [Abstract] Other financing fees Proceeds from (Payments for) Other Financing Activities Debt Instrument, Redemption, Period One Debt Instrument, Redemption, Period One [Member] Total (in shares) Common stock authorized and reserved for future issuance (in shares) Common Stock, Capital Shares Reserved for Future Issuance Leases [Abstract] Leases [Abstract] Entity Central Index Key Entity Central Index Key Security Exchange Name Security Exchange Name Money market funds (included in cash equivalents) Cash and Cash Equivalents, Fair Value Disclosure Issuance of common stock upon exercise of options (in shares) Exercised (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Diluted (in shares) Weighted‑average common shares outstanding—diluted (in shares) Weighted Average Number of Shares Outstanding, Diluted Warrant liabilities Warrant liabilities Warrants and Rights Outstanding Recurring Fair Value, Recurring [Member] Income Taxes Income Tax Disclosure [Text Block] 2008 Plan, 2016 Plan, and 2018 Inducement Incentive Award Plan 2008 Plan, 2016 Plan, and 2018 Inducement Incentive Award Plan [Member] 2008 Plan, 2016 Plan, and 2018 Inducement Incentive Award Plan Research and development Research And Development [Member] Represents the information pertaining to research and development expenses included in the income statement. Related Party [Domain] Related Party [Domain] Current Fiscal Year End Date Current Fiscal Year End Date Summary of Options Activity Share-based Payment Arrangement, Option, Activity [Table Text Block] Spark License Agreement License Agreement Terms [Member] Basis spread on variable rate Debt Instrument, Basis Spread on Variable Rate Equity Stockholders' Equity Note Disclosure [Text Block] Schedule of Potential Common Shares Issuable Upon Conversion of Warrants Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Accrued patent fees Accrued Patent Fees Current Carrying value as of the balance sheet date of patent fees. Non-current liabilities: Other Liabilities, Noncurrent [Abstract] Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Class of Stock [Line Items] Class of Stock [Line Items] Unvested restricted stock units Restricted Stock Units, Unvested [Member] Restricted Stock Units, Unvested Credit Facility [Axis] Credit Facility [Axis] Net cash used in investing activities Net Cash Provided by (Used in) Investing Activities Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Less accumulated depreciation Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Issuance of common stock under Employee Stock Purchase Plan Stock Issued During Period, Value, Employee Stock Purchase Plan Debt issuance costs, line of credit arrangements (less than) Debt Issuance Costs, Line of Credit Arrangements, Net Vested in period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value General and administrative General and Administrative Expense [Member] Expected term Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term Total current liabilities Liabilities, Current Thereafter Lessee, Operating Lease, Liability, To Be Paid, After Year Four Lessee, Operating Lease, Liability, To Be Paid, After Year Four Maximum borrowing capacity Line of Credit Facility, Maximum Borrowing Capacity Money market funds (included in cash equivalents) Money Market Funds [Member] Ownership [Domain] Ownership [Domain] Vested and expected to vest Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value Entity Address, Postal Zip Code Entity Address, Postal Zip Code Less: Debt discount and deferred charges Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net Line of Credit Facility [Line Items] Line of Credit Facility [Line Items] Title of 12(b) Security Title of 12(b) Security Operating Leased Assets [Line Items] Operating Leased Assets [Line Items] Proceeds from issuance of common stock under Employee Stock Purchase Plan Proceeds from Stock Plans Statement [Table] Statement [Table] Initial upfront execution fee payment License And Option Agreement, Execution Fee Payment License And Option Agreement, Execution Fee Payment Unrealized (losses) on marketable securities Marketable Securities, Unrealized Gain (Loss) Collaborative Arrangement and Arrangement Other than Collaborative [Table] Collaborative Arrangement and Arrangement Other than Collaborative [Table] Recent Accounting Pronouncements New Accounting Pronouncements, Policy [Policy Text Block] Prepaid Expenses and Other Current Assets Prepaid Expenses and Other Current Assets [Member] Debt Instrument, Redemption, Period [Domain] Debt Instrument, Redemption, Period [Domain] Statistical Measurement [Axis] Statistical Measurement [Axis] Other financing fees Adjustments to Additional Paid in Capital, Other Collaboration and License Agreements Collaboration And License Agreements [Text Block] Collaboration And License Agreements Subsequent Event Subsequent Event [Member] Cover [Abstract] Cover [Abstract] Vested (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Number of Shares Clinical and commercial milestone payment, expected License And Option Agreement, Clinical And Commercial Milestone Payment, Expected License And Option Agreement, Clinical And Commercial Milestone Payment, Expected Expected volatility Measurement Input, Price Volatility [Member] Schedule of Fair Value Measurement Inputs and Valuation Techniques Fair Value Measurement Inputs and Valuation Techniques [Table Text Block] Upfront cash payment License And Option Agreement, Upfront Cash Payment License And Option Agreement, Upfront Cash 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