Proceeds from exercise of pre-funded and common warrants Proceeds from Warrant Exercises Additional development and regulatory milestone payments License And Option Agreement, Additional Development And Regulatory Milestone Payments That May Be Received License And Option Agreement, Additional Development And Regulatory Milestone Payments That May Be Received Supplement cash flow information Supplemental Cash Flow Information [Abstract] Statutory U.S. federal rate Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent Letter of credit Letter of Credit [Member] Net Loss Per Share Earnings Per Share, Policy [Policy Text Block] Vested in period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period Leasehold improvements Leasehold Improvements [Member] Fair Value Hierarchy and NAV [Domain] Fair Value Hierarchy and NAV [Domain] Net loss Net loss Net Income (Loss) Attributable to Parent 2021 Sales Agreement 2021 Sales Agreement [Member] 2021 Sales Agreement Spark Letter Agreement Spark Letter Agreement [Member] Spark Letter Agreement [Member] Right-of-use asset, net Operating Lease, Right-of-Use Asset Class of warrant or right, number of warrants exercised (in shares) Class Of Warrant Or Right, Number Of Warrants Exercised Class of Warrant or Right, Number Of Warrants Exercised Weighted-average remaining contractual term Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term [Abstract] n/a Marketable securities Debt Securities, Available-for-sale, Current Net operating loss carryforwards Deferred Tax Assets, Operating Loss Carryforwards Preferred stock, shares outstanding (in shares) Preferred Stock, Shares Outstanding Payroll and employee related expenses Employee-related Liabilities, Current Income Statement Location [Axis] Income Statement Location [Axis] Statistical Measurement [Domain] Statistical Measurement [Domain] Contract liabilities, additions Contract with Customer, Liability, Increase From Cash Receipts Contract with Customer, Liability, Increase From Cash Receipts Schedule of Future Minimum Payments on the Term Loans Schedule of Maturities of Long-term Debt [Table Text Block] Valuation technique, option pricing model Valuation Technique, Option Pricing Model [Member] Segment Information Segment Reporting, Policy [Policy Text Block] Redemption premium Redemption Premium Security Exchange Name Security Exchange Name Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Proceeds from the sale of property and equipment Proceeds from Sale of Property, Plant, and Equipment Forfeited in period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Revenue from Contract with Customer [Abstract] Revenue from Contract with Customer [Abstract] Schedule of Changes in Contract Liabilities Contract with Customer, Contract Asset, Contract Liability, and Receivable [Table Text Block] Forfeited (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period Operating lease, weighted average remaining lease term Operating Lease, Weighted Average Remaining Lease Term Equity securities without readily determinable fair value, impairment loss Equity Securities without Readily Determinable Fair Value, Impairment Loss, Annual Amount Number of amendments License and Option Agreement, Number Of Amendments License and Option Agreement, Number Of Amendments Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Dividend yield Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate Number of shares authorized for grants (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant Retirement Benefits [Abstract] Retirement Benefits [Abstract] Net change in cash, cash equivalents, and restricted cash Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Entity File Number Entity File Number Issuance (in dollars per share) Stock Issued During, Warranted Issued, Price Per Share Stock Issued During, Warranted Issued, Price Per Share Expected volatility Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate 2023 Long-Term Debt, Maturity, Year Two Schedule of Operating Lease, Lease Income Operating Lease, Lease Income [Table Text Block] Accrued external research and development costs Accrued Research And Development Costs Current Carrying value as of the balance sheet date of research and development costs. Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] Stock-based compensation expense APIC, Share-based Payment Arrangement, Increase for Cost Recognition Consulting services expenses Related Party Transaction, Expenses from Transactions with Related Party Income taxes payable Increase (Decrease) in Income Taxes Payable Change in fair value Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings Summary of Available-for-Sale Marketable Securities Debt Securities, Available-for-sale [Table Text Block] Number of votes per share that common stockholders are entitled to Votes Per Share of Common Stock Votes Per Share of Common Stock Awarded in period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Awarded in Period Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Awarded in Period Subsequent Event Type [Domain] Subsequent Event Type [Domain] Lessee, Lease, Description [Line Items] Lessee, Lease, Description [Line Items] Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements [Abstract] Valuation Approach and Technique [Domain] Valuation Approach and Technique [Domain] Issuance costs paid for December 2019 financing Payments of Financing Costs Other Current Assets Other Current Assets [Member] Variable lease cost Variable Lease, Cost Net deferred tax assets Deferred Tax Assets, Net August 2020 Shelf Registration Statement August 2020 Shelf Registration Statement [Member] August 2020 Shelf Registration Statement Operating lease, weighted average discount rate, percent Operating Lease, Weighted Average Discount Rate, Percent Total (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Revenue recognized Contract liabilities, deductions Contract with Customer, Liability, Revenue Recognized Sale of Stock [Axis] Sale of Stock [Axis] Liability Class [Axis] Liability Class [Axis] Subsequent Events [Abstract] Subsequent Events [Abstract] Warrants Warrants [Policy Text Block] Warrants Private Placement Private Placement [Member] Grants in period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Audit Information [Abstract] Audit Information [Abstract] Proceeds from maturities of marketable securities Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-sale Unrealized (losses) on marketable securities Unrealized loss on marketable securities OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax Income Tax Examination [Table] Income Tax Examination [Table] Schedule of Operating Leased Assets [Table] Schedule of Operating Leased Assets [Table] Award Type [Domain] Award Type [Domain] Issuance of common stock, pre-funded warrants and warrants through private placement Stock Issued During Period, Value, Pre-Funded Warrants And Warrants Through Private Placement Stock Issued During Period, Value, Pre-Funded Warrants And Warrants Through Private Placement Local Phone Number Local Phone Number Credit Facility [Domain] Credit Facility [Domain] Assets Assets [Abstract] Related Party Transactions [Abstract] Related Party Transactions [Abstract] Employment Inducement Incentive Award Plan Employment Inducement Incentive Award Plan [Member] Employment Inducement Incentive Award Plan [Member] 2024 Long-Term Debt, Maturity, Year Three Vested and expected to vest (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price Loan payable Loans Payable, Current Federal operating loss carryforwards Deferred Tax Assets, Operating Loss Carryforwards, Domestic Vesting period Defined Contribution Plan Employers Matching Contribution Vesting Period Period which an employee's right to exercise a plan is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. Grants in period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period Preferred stock, $0.0001 par value; 10,000,000 shares authorized; no shares issued and outstanding at December 31, 2021 and December 31, 2020 Preferred Stock, Value, Issued Property and Equipment Property, Plant and Equipment, Policy [Policy Text Block] Beginning balance (in shares) Ending balance (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Clinical Trial Costs Clinical Trial Costs [Policy Text Block] Clinical Trial Costs Accumulated deficit Retained Earnings [Member] Prepaid expenses, deposits and other assets Increase (Decrease) in Prepaid Expense and Other Assets Lease Arrangement [Axis] Lease Arrangement [Axis] Lease Arrangement [Axis] Area of additional office space leased Area of Real Estate Property Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] Skolkovo Skolkovo [Member] Skolkovo Accrued interest Accrued Interest, Current Accrued Interest, Current Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Related Party [Axis] Related Party [Axis] 65 Grove Street, Watertown,MA 65 Grove Street, Watertown,MA [Member] 65 Grove Street, Watertown,MA [Member] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] Accounts receivable Increase (Decrease) in Accounts Receivable Purchase of property and equipment not yet paid Capital Expenditures Incurred but Not yet Paid Schedule of Deferred Tax Assets and Liabilities Schedule of Deferred Tax Assets and Liabilities [Table Text Block] Property, Plant and Equipment [Line Items] Property, Plant and Equipment [Line Items] Entity Well-known Seasoned Issuer Entity Well-known Seasoned Issuer Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Final payment fee Debt Instrument, Periodic Payment Terms, Balloon Payment to be Paid Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] Number of operating segments Number of Operating Segments Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] Basic (in dollars per share) Earnings Per Share, Basic 2024 Lessee, Operating Lease, Liability, to be Paid, Year Three Revenue Arrangements Revenue from Contract with Customer [Text Block] Unvested at beginning of period (in shares) Unvested at end of period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Fair value as of December 31, 2020 Fair value as of December 31, 2021 Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value 2022 Long-Term Debt, Maturity, Year One Interest expense related to term loans Interest Expense, Debt Warrant, decrease in equity, amount Warrant, Down Round Feature, (Increase) Decrease in Equity, Amount Employer contribution made Defined Contribution Plan, Cost Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Commercial paper Commercial Paper [Member] Cash paid for amounts included in the measurement of lease liabilities: Operating Lease, Payments December 2019 Financing December Two Thousand Nineteen Financing [Member] December Two Thousand Nineteen Financing [Member] Restricted cash and cash equivalents Restricted Cash and Cash Equivalents Depreciation Deferred Tax Liabilities, Property, Plant and Equipment Research and Development Costs Research and Development Expense, Policy [Policy Text Block] Aggregate amount of upfront and milestone-based payments Aggregate Amount Of Upfront And Milestone Based Payments Paid Aggregate Amount Of Upfront And Milestone Based Payments Paid Laboratory equipment Laboratory Equipment [Member] Represents information pertaining to laboratory equipment. Depreciation and amortization Other Depreciation and Amortization Operating lease right-of-use asset Deferred Tax Liabilities, Operating Lease, Right-Of-Use Asset Deferred Tax Liabilities, Operating Lease, Right-Of-Use Asset Aggregate amount for future payments upon achievement of clinical and regulatory approval milestones for products containing ImmTOR platform Aggregate Amount For Future Payments Upon Achievement Of Clinical And Regulatory Approval Milestones For Products Containing ImmTOR Platform Aggregate Amount For Future Payments Upon Achievement Of Clinical And Regulatory Approval Milestones For Products Containing ImmTOR Platform Series B Preferred Stock Purchase Agreement Series B Preferred Stock Purchase Agreement [Member] Series B Preferred Stock Purchase Agreement Debt Instrument, Redemption, Period Two Debt Instrument, Redemption, Period Two [Member] Entity Voluntary Filers Entity Voluntary Filers Plan Name [Axis] Plan Name [Axis] Assets: Assets, Fair Value Disclosure [Abstract] Pre-Funded Warrant Pre-Funded Warrant [Member] Pre-Funded Warrant [Member] Total minimum principal payments Long-term Debt Total assets Assets, Fair Value Disclosure Level 1 Fair Value, Inputs, Level 1 [Member] Equity securities, stock purchase agreement, par value per share (in dollars per share) Equity Securities, Stock Purchase Agreement, Par Value Per Share Equity Securities, Stock Purchase Agreement, Par Value Per Share Fair Value by Liability Class [Domain] Fair Value by Liability Class [Domain] Income Tax Disclosure [Abstract] Income Tax Disclosure [Abstract] Entity Smaller Reporting Company Entity Small Business Total liabilities and stockholders’ equity (deficit) Liabilities and Equity Other Effective Income Tax Rate Reconciliation, Other Adjustments, Percent Other Other Accrued Liabilities, Current Investments, Debt and Equity Securities [Abstract] Investments, Debt and Equity Securities [Abstract] Deferred revenue Short-term contract liability Contract with Customer, Liability, Current 2026 Lessee, Operating Lease, Liability, to be Paid, Year Five Exercised (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Additional paid-in capital Additional Paid in Capital Lessee, Lease, Description [Table] Lessee, Lease, Description [Table] Number of obligations Revenue, Number Of Performance Obligations Revenue, Number Of Performance Obligations Concentration Risk [Line Items] Concentration Risk [Line Items] Liabilities and stockholders’ equity (deficit) Liabilities and Equity [Abstract] Accounts payable Increase (Decrease) in Accounts Payable Commercialization milestone payments License And Option Agreement, Commercialization Milestone Payments That May Be Received License And Option Agreement, Commercialization Milestone Payments That May Be Received Cash flows from operating activities Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Net Loss Per Share Earnings Per Share [Text Block] Entity Interactive Data Current Entity Interactive Data Current Cash and Cash Equivalents [Domain] Cash and Cash Equivalents [Domain] Non-cash interest expense Paid-in-Kind Interest Issuance of common stock upon exercise of options Stock Issued During Period, Value, Stock Options Exercised Minimum Minimum [Member] Description of the Business Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] MIT Exclusive Patent License Agreement With Massachusetts Institute Of Technology [Member] Represents information pertaining to Exclusive patent license agreement with Massachusetts Institute of Technology. " Issuance of common stock, pre-funded warrants and warrants through private placement (in shares) Stock Issued During Period, Value, Pre-Funded Warrants And Warrants Through Private Placement, Shares Stock Issued During Period, Value, Pre-Funded Warrants And Warrants Through Private Placement, Shares Term loan facility Long-term Line of Credit 2023 Lessee, Operating Lease, Liability, to be Paid, Year Two Total liabilities Financial and Nonfinancial Liabilities, Fair Value Disclosure Class of Warrant or Right [Line Items] Class of Warrant or Right [Line Items] Schedule of Authorized Shares of Common Stock for Future Issuance Schedule of Stock by Class [Table Text Block] Stock Offering, Excluding At The Market Offering And Private Placement Stock Offering, Excluding At The Market Offering And Private Placement [Member] Stock Offering, Excluding At The Market Offering And Private Placement Preferred stock, shares authorized (in shares) Preferred Stock, Shares Authorized Unrecognized tax benefits Unrecognized Tax Benefits Income Tax Authority [Domain] Income Tax Authority [Domain] Gross deferred tax assets Deferred Tax Assets, Gross Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Unrealized gains Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax Entity Address, State or Province Entity Address, State or Province Non-employee stock options Non-employee consultants Non Employee Stock Option [Member] An arrangement whereby a non-employee is entitled to receive in the future, subject to vesting and other restrictions, a number of shares in the entity at a specified price, as defined in the agreement. Net deferred tax assets before valuation allowance Deferred Tax Assets, Net Of Deferred Tax Liabilities Deferred Tax Assets, Net Of Deferred Tax Liabilities Current liabilities: Liabilities, Current [Abstract] Period after first commercial sale when the Company is eligible to receive royalties Eligible Period To Receive Royalties Eligible Period To Receive Royalties Class of Warrant or Right [Table] Class of Warrant or Right [Table] 2025 Long-Term Debt, Maturity, Year Four Issuance of common stock, net of issuance costs Stock Issued During Period, Value, New Issues Long-term restricted cash Restricted Cash and Cash Equivalents, Noncurrent General and administrative General and Administrative Expense ESPP Employee Stock Purchase Plan2016 [Member] Represent information pertaining to the 2016 Employee Stock Purchase Plan. Estimated forfeitures rate Share-based Compensation Arrangement By Share-based Payment Award Forfeitures Rate Represents the percentage of forfeitures rate of the stock options based on the historical trends. Debt Debt Disclosure [Text Block] Issuance of vested restricted stock units Stock Issued During Period, Value, Restricted Stock Award, Gross Patent costs/amortization Deferred Tax Assets, Goodwill and Intangible Assets Stock Incentive Plans Share-based Payment Arrangement [Text Block] Level 3 Fair Value, Inputs, Level 3 [Member] Leases Lessee, Leases [Policy Text Block] Debt instrument, prepayment fee, percentage Debt Instrument, Prepayment Fee, Percentage Debt Instrument, Prepayment Fee, Percentage Fair Value Measurement Inputs and Valuation Techniques [Line Items] Fair Value Measurement Inputs and Valuation Techniques [Line Items] Accounting Policies [Abstract] Accounting Policies [Abstract] Debt issuance costs in accrued liabilities Debt Issuance Costs Incurred During Noncash or Partial Noncash Transaction Outstanding, term Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Issuance costs Payments of Stock Issuance Costs Issuance of common stock, net of issuance costs (in shares) Stock Issued During Period, Shares, New Issues 2016 Plan Stock Incentive Plan2016 [Member] Represents the information pertaining to the 2016 stock incentive plan, which provides for the granting of stock based awards to employees, directors, and consultants under terms and provisions established by the board of directors. Operating expenses: Cost of Revenue [Abstract] Lease liabilities Operating Lease, Liability Document Transition Report Document Transition Report Foreign currency transaction gain (loss), net Foreign Currency Transaction Gain (Loss), before Tax Common stock, $0.0001 par value; 200,000,000 shares authorized; 123,622,965 and 108,071,249 shares issued and outstanding as of December 31, 2021 and December 31, 2020, respectively Common Stock, Value, Issued Disaggregation of Revenue [Line Items] Disaggregation of Revenue [Line Items] Weighted average period for recognition Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Unvested at beginning of period (in dollars per share) Unvested at end of period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Equity offering costs in accrued liabilities Equity Offering Costs In Accrued Liabilities Equity Offering Costs In Accrued Liabilities Commitments and contingencies Commitments and Contingencies Long-term Debt, Fiscal Year Maturity [Abstract] Long-term Debt, Fiscal Year Maturity [Abstract] Subsequent Event [Table] Subsequent Event [Table] Leases Lessee, Operating Leases [Text Block] Accumulated other comprehensive loss Accumulated Other Comprehensive Income (Loss), Net of Tax Entity Emerging Growth Company Entity Emerging Growth Company Vested, term Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Weighted Average Remaining Contractual Term Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Weighted Average Remaining Contractual Term Non-cash lease expense Finance Lease, Right-of-Use Asset, Amortization Contract liabilities: Change In Contract With Customer, Liability [Roll Forward] Change In Contract With Customer, Liability [Roll Forward] ICFR Auditor Attestation Flag ICFR Auditor Attestation Flag Ginkgo Agreement Ginkgo Agreement [Member] Ginkgo Agreement Schedule of Weighted Average Assumptions Used Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Ownership [Axis] Ownership [Axis] Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Marketable Securities and Investments Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block] Auditor Name Auditor Name Cover [Abstract] Cover [Abstract] Moscow Russia Lease Moscow Russia Lease [Member] Moscow Russia Lease Issuance of common stock upon exercise of common warrants (in shares) Stock Issued During Period, Shares, Common Warrants Exercised Stock Issued During Period, Shares, Common Warrants Exercised Class of Stock [Axis] Class of Stock [Axis] Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Class of warrant or right, outstanding (in shares) Class of warrant or right, outstanding, beginning balance (in shares) Class of warrant or right, outstanding, ending balance (in shares) Class of Warrant or Right, Outstanding Less imputed interest Lessee, Operating Lease, Liability, Undiscounted Excess Amount Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table] Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table] Term A Loans Term A Loans [Member] Term A Loans Income Tax Authority [Axis] Income Tax Authority [Axis] Sale common stock Sale of Stock, Consideration Received on Transaction Cash maintained in Russian bank accounts Cash Fair value, measurement with unobservable inputs reconciliation, recurring basis, liability, transfers, net Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Transfers, Net Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Financial Instrument [Axis] Financial Instrument [Axis] Accrued expenses Accrued expenses Accrued Liabilities, Current Collaboration and license revenue Grant and collaboration revenue (less than) Revenue from Contract with Customer, Excluding Assessed Tax Stock-based compensations expense Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost Net proceeds from issuance of common stock- private placement Proceeds from Issuance of Private Placement Office equipment Office Equipment [Member] Numerator: Net Income (Loss) Available to Common Stockholders, Basic [Abstract] Outstanding common stock options Share-based Payment Arrangement, Option [Member] Equity [Abstract] Equity [Abstract] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Accumulated Other Comprehensive Income (Loss) Comprehensive Income, Policy [Policy Text Block] Research tax credits Effective Income Tax Rate Reconciliation, Tax Credit, Percent Operating loss carryforwards, carried forward indefinitely Deferred Tax Assets, Operating Loss Carryforwards, Not Subject to Expiration Measurement Input Type [Domain] Measurement Input Type [Domain] Effect of exchange rate changes on cash Effect of Exchange Rate on Cash and Cash Equivalents Change in fair value of warrant liabilities Warrant liabilities revaluation Fair Value Adjustment of Warrants Common stock Common Stock [Member] Operating loss Operating Income (Loss) Property, Plant and Equipment [Table] Property, Plant and Equipment [Table] Debt Securities, Available-for-sale [Line Items] Debt Securities, Available-for-sale [Line Items] Lease liability Operating Lease, Liability, Current Unrealized losses Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax Schedule of Cash and Cash Equivalents [Table] Schedule of Cash and Cash Equivalents [Table] Increase (Decrease) in Stockholders' Equity Increase (Decrease) in Stockholders' Equity [Roll Forward] Document Fiscal Year Focus Document Fiscal Year Focus Property, Plant and Equipment [Abstract] Property, Plant and Equipment [Abstract] Stock-based compensation expense Share-based Payment Arrangement, Noncash Expense Payment made for investments Payments to Acquire Other Investments Additional paid-in capital Additional Paid-in Capital [Member] Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Depreciation expense Depreciation Vested Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Intrinsic Value Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Intrinsic Value Weighted-average fair value of common stock (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Weighted Average Fair Value Weighed-average fair value relating to the share-based payment award. Purchases of marketable securities Payments to Acquire Debt Securities, Available-for-sale Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Class of warrant or right, number of securities called by warrants or rights (in shares) Class of Warrant or Right, Number of Securities Called by Warrants or Rights Deferred revenue, additions Contract with Customer, Liability, Deferred Revenue, Increase From Cash Receipts Contract with Customer, Liability, Deferred Revenue, Increase From Cash Receipts Other income (expense), net Other Nonoperating Income (Expense) Contractual payments defined in the Exclusive Patent License agreement License And Option Agreement, Contractual Payments Made License And Option Agreement, Contractual Payments Made Debt instrument, redemption price, percentage of principal amount redeemed Debt Instrument, Redemption Price, Percentage of Principal Amount Redeemed Fair value of warrants issued in connection with issuance of long-term debt Stock Issued Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment Valuation Approach and Technique [Axis] Valuation Approach and Technique [Axis] Takeda Agreement Takeda Agreement [Member] Takeda Agreement Cash Equivalents, Restricted Cash, Marketable Securities and Investments Cash Equivalents And Short Term Investments [Policy Text Block] Cash Equivalents And Short Term Investments Deferred revenue Deferred Tax Assets, Deferred Income Maximum Maximum [Member] Share-based Payment Arrangement [Abstract] Share-based Payment Arrangement [Abstract] Total liabilities Liabilities Schedule of Accrued Expenses Schedule of Accrued Liabilities [Table Text Block] Award Type [Axis] Award Type [Axis] Granted (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Outstanding Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value Schedule of Lessee, Operating Lease, Liability, Maturity Lessee, Operating Lease, Liability, Maturity [Table Text Block] Measurement Input Type [Axis] Measurement Input Type [Axis] Total stockholders’ equity (deficit) Beginning balance Ending balance Stockholders' Equity Attributable to Parent Common stock, shares issued (in shares) Common Stock, Shares, Issued Preferred stock, shares issued (in shares) Preferred Stock, Shares Issued City Area Code City Area Code Short-term restricted cash Restricted Cash and Cash Equivalents, Current Equity securities, stock purchase agreement, purchase price per share (in dollars per share) Equity Securities, Stock Purchase Agreement, Purchase Price Per Share Equity Securities, Stock Purchase Agreement, Purchase Price Per Share Goodwill and Intangible Assets Disclosure [Abstract] Goodwill and Intangible Assets Disclosure [Abstract] Expected life (in years) Measurement Input, Expected Term [Member] Entity Address, City or Town Entity Address, City or Town Research and Development Arrangement, Contract to Perform for Others, Type [Axis] Research and Development Arrangement, Contract to Perform for Others, Type [Axis] Loss on extinguishment of debt Loss on extinguishment of debt Gain (Loss) on Extinguishment of Debt Estimated useful life Property, Plant and Equipment, Useful Life Other expenses Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Other Stockholders’ equity (deficit): Stockholders' Equity Attributable to Parent [Abstract] Noncash investing and financing activities Noncash Investing and Financing Items [Abstract] Concentrations of Credit Risk and Off-Balance Sheet Risk Concentration Risk, Credit Risk, Policy [Policy Text Block] Investment income Investment Income, Net Lease liability, net of current portion Operating Lease, Liability, Noncurrent Measurement Frequency [Domain] Measurement Frequency [Domain] Current tax expense, inclusive of estimated penalties and interest Current Income Tax Expense (Benefit) Face value Debt Instrument, Face Amount Interest expense Interest Expense SOBI Purchase Agreement SOBI Purchase Agreement [Member] SOBI Purchase Agreement [Member] Cost share percentage Collaborative Arrangement, Cost Share Percentage Collaborative Arrangement, Cost Share Percentage Springer Purchase Agreement Springer Purchase Agreement [Member] Springer Purchase Agreement [Member] Operating lease liability Deferred Tax Assets, Operating Lease, Liability Deferred Tax Assets, Operating Lease, Liability Contract assets amortization (less than) Capitalized Contract Cost, Amortization Venture debt termination fee Debt Instrument, Termination Fee Debt Instrument, Termination Fee Accumulated deficit Accumulated deficit Retained Earnings (Accumulated Deficit) Options, RSUs and ESPP shares Shares available for future stock incentive awards Share-based Payment Arrangement [Member] Income Tax Examination [Line Items] Income Tax Examination [Line Items] Term of contract Lessee, Operating Lease, Term of Contract 2017 Term Loans 2017 Term Loans [Member] 2017 Term Loans [Member] Fair Value Measurement Inputs and Valuation Techniques [Table] Fair Value Measurement Inputs and Valuation Techniques [Table] Restricted Stock Units (RSUs) Restricted Stock Units (RSUs) [Member] Statement of Stockholders' Equity [Abstract] Statement of Stockholders' Equity [Abstract] Issuance of common stock under Employee Stock Purchase Plan (in shares) Stock Issued During Period, Shares, Employee Stock Purchase Plans Entity Filer Category Entity Filer Category Gross deferred tax liabilities Deferred Tax Liabilities, Gross Marketable securities adjusted for other than temporary declines in fair value Other-than-temporary Impairment Loss, Debt Securities, Available-for-sale Risk-free interest rate Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Schedule of Restricted Cash and Cash Equivalents Restrictions on Cash and Cash Equivalents [Table Text Block] Concentration Risk [Table] Concentration Risk [Table] Entity Registrant Name Entity Registrant Name Fair value, measurement with unobservable inputs reconciliation, recurring basis, asset, transfers, net Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Transfers, Net Schedule Of Changes In The Warrant Liabilities Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block] First Acquisition Right First Acquisition Right [Member] First Acquisition Right [Member] Repayments of lines of credit Repayments of Lines of Credit Proceeds from exercise of stock options Proceeds from Stock Options Exercised Future additional payments, expected License And Option Agreement, Future Additional Payments, Expected License And Option Agreement, Future Additional Payments, Expected Issuance of vested restricted stock units (in shares) Stock Issued During Period, Shares, Restricted Stock Award, Gross Forfeited (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price Income tax expense Income Tax Expense (Benefit) Cash, cash equivalents, restricted cash and marketable securities Cash, Cash Equivalents, Restricted Cash And Restricted Cash Equivalents And Debt Securities, Available-For-Sale Cash, Cash Equivalents, Restricted Cash And Restricted Cash Equivalents And Debt Securities, Available-For-Sale Accounts receivable Accounts Receivable, after Allowance for Credit Loss, Current Amendment Flag Amendment Flag Proceeds from issuance of long-term debt, net of expenses Proceeds from Issuance of Long-term Debt Equity Components [Axis] Equity Components [Axis] Entity Tax Identification Number Entity Tax Identification Number Vested (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Weighted Average Exercise Price Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Weighted Average Exercise Price Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] Equity securities, stock purchase agreement, shares purchased (in shares) Equity Securities, Stock Purchase Agreement, Shares Purchased Equity Securities, Stock Purchase Agreement, Shares Purchased Antidilutive Securities [Axis] Antidilutive Securities [Axis] Document Fiscal Period Focus Document Fiscal Period Focus Total current assets Assets, Current Disaggregation of Revenue [Table] Disaggregation of Revenue [Table] Total future minimum lease payments Lessee, Operating Lease, Liability, to be Paid Accrued professional and consulting services Accrued Audit Fees, Current Accrued Audit Fees, Current Sale of Stock [Domain] Sale of Stock [Domain] Forfeited in period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period Class Of Warrant Or Right [Roll Forward] Class Of Warrant Or Right [Roll Forward] Class Of Warrant Or Right [Roll Forward] Class Of Warrant Or Right Weighted Average Exercise Price [Roll Forward] Class Of Warrant Or Right Weighted Average Exercise Price [Roll Forward] Class Of Warrant Or Right Weighted Average Exercise Price [Roll Forward] Schedule of Stock by Class [Table] Schedule of Stock by Class [Table] Stock-Based Compensation Share-based Payment Arrangement [Policy Text Block] Issuance of common warrants with long-term debt, net Adjustments to Additional Paid in Capital, Warrant Issued Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Thereafter Lessee, Operating Lease, Liability, to be Paid, after Year Five Valuation allowance, deferred tax asset, increase, amount Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount Unrecognized compensation expense related to unvested employee stock options Share-based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount Less: Current portion of loan payable Long-term Debt, Current Maturities Product and Service [Axis] Product and Service [Axis] Schedule of Stockholders' Equity Note, Warrants or Rights Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block] Long-Lived Tangible Asset [Domain] Long-Lived Tangible Asset [Domain] Cash flows from financing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Schedule of Cash and Cash Equivalents Schedule of Cash and Cash Equivalents [Table Text Block] Issuance of common stock upon exercise of warrants Stock Issued During Period, Value, Common Warrants Exercised Stock Issued During Period, Value, Common Warrants Exercised Preferred stock, par value (in dollars per share) Preferred Stock, Par or Stated Value Per Share Investments Equity securities without readily determinable fair value, amount Equity Securities without Readily Determinable Fair Value, Amount Entity Public Float Entity Public Float Stock compensation Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-based Payment Arrangement, Percent Documents Incorporated by Reference Documents Incorporated by Reference [Text Block] Unrecognized compensation expense Share-based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount Weighted average grant date fair value of stock options (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Equity Component [Domain] Equity Component [Domain] Short-term lease cost Short-term Lease, Cost Debt Instrument, Redemption, Period Three Debt Instrument, Redemption, Period Three [Member] 2022 Lessee, Operating Lease, Liability, to be Paid, Year One Foreign currency translation adjustment Currency translation adjustment Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax Research and Development Arrangement, Contract to Perform for Others, Type [Domain] Research and Development Arrangement, Contract to Perform for Others, Type [Domain] Shares of common stock issued to employees under the ESPP (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period Accrued expenses and other liabilities Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities Statement [Line Items] Statement [Line Items] Deferred revenue Increase (Decrease) in Contract with Customer, Liability Two payments due within 12 months of contract date License And Option Agreement, Two Payments Due Within Twelve Months Of Contract Date License And Option Agreement, Two Payments Due Within Twelve Months Of Contract Date Long-term restricted cash Restricted Cash, Noncurrent Cashless warrant exercise Noncash Or Part Noncash, Warrant Exercises Noncash Or Part Noncash, Warrant Exercises License and option agreement, written day notice period before cancellation License And Option Agreement, Written Day Notice Period Before Cancellation License And Option Agreement, Written Day Notice Period Before Cancellation Remaining performance obligation Revenue, Remaining Performance Obligation, Amount Development milestone License And Option Agreement, Development Milestone License And Option Agreement, Development Milestone Weighted-average exercise price Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Sarepta Therapeutics, Inc. Sarepta Therapeutics, Inc. [Member] Sarepta Therapeutics, Inc. [Member] Domestic Tax Authority Domestic Tax Authority [Member] Schedule of Stock-Based Compensation Share-based Payment Arrangement, Cost by Plan [Table Text Block] Fair value Marketable securities: Debt Securities, Available-for-sale Valuation allowance, net Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent 2025 Lessee, Operating Lease, Liability, to be Paid, Year Four Debt Disclosure [Abstract] Debt Disclosure [Abstract] Founders Founder [Member] Represents information pertaining to founder member. Disclosure of Share-based Compensation Arrangements by Share-based Payment Award Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block] Loss before income taxes Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Number of shares authorized, increase (in shares) Share-Based Compensation Arrangement By Share-Based Payment Award, Number Of Shares Available For Grant, Increase (Decrease) Share-Based Compensation Arrangement By Share-Based Payment Award, Number Of Shares Available For Grant, Increase (Decrease) Level 2 Fair Value, Inputs, Level 2 [Member] Deferred revenue, beginning of period Deferred revenue, end of period Contract with Customer, Liability, Deferred Revenue Contract with Customer, Liability, Deferred Revenue Long-Lived Tangible Asset [Axis] Long-Lived Tangible Asset [Axis] Valuation allowance Deferred Tax Assets, Valuation Allowance Subsidiary, Sale of Stock [Line Items] Subsidiary, Sale of Stock [Line Items] Dividend yield Measurement Input, Expected Dividend Rate [Member] Deferred revenue Long-term contract liability Contract with Customer, Liability, Noncurrent Auditor Location Auditor Location Amortized cost Debt Securities, Available-for-sale, Amortized Cost Loan payable, net of current portion Loans Payable, Noncurrent Defined Contribution Plan Retirement Benefits [Text Block] Use of Estimates Use of Estimates, Policy [Policy Text Block] Granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross Computation of Basic and Diluted Net Loss Per Share Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Accrued interest related to uncertain tax positions Unrecognized Tax Benefits, Interest on Income Taxes Accrued Document Annual Report Document Annual Report Aggregate intrinsic value Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value [Abstract] n/a Title of 12(b) Security Title of 12(b) Security Net proceeds from issuance of common stock Proceeds from Issuance of Common Stock Total assets Assets Net realized losses on marketable securities Realized Investment Gains (Losses) Plan Name [Domain] Plan Name [Domain] Common stock, shares authorized (in shares) Common Stock, Shares Authorized Cash paid for interest Interest Paid, Excluding Capitalized Interest, Operating Activities Geographical [Domain] Geographical [Domain] Document Type Document Type Aggregate purchase price Aggregate Purchase Price Aggregate Purchase Price Product and Service [Domain] Product and Service [Domain] Accrued Expenses Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block] Research and development Research and Development Expense Operating lease, renewal term Lessee, Operating Lease, Renewal Term Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Debt instrument, default, bankruptcy, or insolvency value of triggering accelerated redemption Debt Instrument, Default, Bankruptcy, Or Insolvency Value Of Triggering Accelerated Redemption Debt Instrument, Default, Bankruptcy, Or Insolvency Value Of Triggering Accelerated Redemption Exercises (in dollars per share) Warrant, Exercise Price, Increase Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Issuances (in shares) Stock Issued During Period Shares Warranted Issued Stock Issued During Period Shares Warranted Issued Measurement Frequency [Axis] Measurement Frequency [Axis] Net cash (used in) provided by operating activities Net Cash Provided by (Used in) Operating Activities Schedule of Term Loan And Unamortized Debt Discount Balances Schedule of Debt [Table Text Block] Fair Value, Recurring and Nonrecurring [Table] Fair Value, Recurring and Nonrecurring [Table] Furniture and fixtures Furniture and Fixtures [Member] Schedule of Long-term Debt Instruments [Table] Schedule of Long-term Debt Instruments [Table] Schedule of Lease, Cost Lease, Cost [Table Text Block] Corporate bonds Corporate Bond Securities [Member] Cash and Cash Equivalents [Line Items] Cash and Cash Equivalents [Line Items] Subsequent Event [Line Items] Subsequent Event [Line Items] Net loss per share: Earnings Per Share, Basic [Abstract] Geographical [Axis] Geographical [Axis] Permanent items Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent Basic (in shares) Weighted-average common shares outstanding, basic (in shares) Weighted Average Number of Shares Outstanding, Basic Diluted (in dollars per share) Earnings Per Share, Diluted State and Local Jurisdiction State and Local Jurisdiction [Member] Common Warrant Common Warrant [Member] Common Warrant [Member] Share price (in dollars per share) Sale of Stock, Price Per Share Russian subsidiary Russian subsidiary RUSSIAN FEDERATION Subsequent Events Subsequent Events [Text Block] Deferred revenue Effective Income Tax Rate Reconciliation, Deferred Revenue, Percent Effective Income Tax Rate Reconciliation, Deferred Revenue, Percent Total comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Deferred revenue related to agreement Contract liabilities, beginning of period Contract liabilities, end of period Contract with Customer, Liability Net cash provided by financing activities Net Cash Provided by (Used in) Financing Activities Weighted average common shares outstanding: Denominator: Weighted Average Number of Shares Outstanding, Diluted [Abstract] Debt Issuance Costs Debt, Policy [Policy Text Block] Related Party Transaction [Line Items] Related Party Transaction [Line Items] Award vesting term Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period AskBio License AskBio License [Member] AskBio License [Member] Schedule of Effective Income Tax Rate Reconciliation Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] Fair Value Measurements Fair Value Disclosures [Text Block] Accounts payable Accounts Payable, Current 2017 PIPE 2017 PIPE [Member] 2017 PIPE [Member] Dividends declared or paid on common stock Dividends, Common Stock Summary of Assets Measured at Fair Value on a Recurring Basis Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Deferred Tax Liabilities Deferred Tax Liabilities, Gross [Abstract] Accumulated other comprehensive loss AOCI Attributable to Parent [Member] Other assets Other Assets Common stock, shares outstanding (in shares) Beginning balance (in shares) Ending balance (in shares) Common Stock, Shares, Outstanding Financial Instruments [Domain] Financial Instruments [Domain] Other comprehensive income (loss): Other Comprehensive Income (Loss), Tax [Abstract] Debt instrument, additional accrued interest in the event of default Debt Instrument, Additional Accrued Interest In the Event Of Default Debt Instrument, Additional Accrued Interest In the Event Of Default Document Period End Date Document Period End Date Entity Central Index Key Entity Central Index Key Potential common shares Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Number of Options Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] Cyrus Biotechnology, Inc. Cyrus Biotechnology, Inc. [Member] Cyrus Biotechnology, Inc. Deferred Tax Assets Deferred Tax Assets, Gross [Abstract] Lease Arrangement [Domain] Lease Arrangement [Domain] [Domain] for Lease Arrangement [Axis] State income taxes - net of federal benefit Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent Collaboration and licensing Accrued Collaboration and Licensing Accrued Collaboration and Licensing Cash flows from investing activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Lessee-paid construction costs Total lease cost Lease, Cost Schedule of Property and Equipment Property, Plant and Equipment [Table Text Block] Research and development credits Deferred Tax Assets, Tax Credit Carryforwards, Research Income Statement Location [Domain] Income Statement Location [Domain] At-The-Market Offering At-The-Market Offering [Member] At-The-Market Offering [Member] Debt Securities, Available-for-sale [Table] Debt Securities, Available-for-sale [Table] License Agreement For Pompe Disease License Agreement For Pompe Disease [Member] License Agreement For Pompe Disease [Member] 2020 Term Loans 2020 Term Loans [Member] 2020 Term Loans Warrant issued Warrant Issued Warrant Issued Class of warrant or right, expiration period Class Of Warrant Or Right, Expiration Period Class Of Warrant Or Right, Expiration Period Property and equipment, net Property and equipment, net Property, Plant and Equipment, Net Property and Equipment Property, Plant and Equipment Disclosure [Text Block] Total operating expenses Operating expenses Operating Expenses License and option agreement, payments made relative to calculated premium paid for initial equity investment made under the purchase agreement License And Option Agreement, Calculated Premium Paid For Equity Investment Under Purchase Agreement License And Option Agreement, Calculated Premium Paid For Equity Investment Under Purchase Agreement Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table] Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table] Debt Instrument [Line Items] Debt Instrument [Line Items] Repayments of principal on outstanding debt Repayments of Long-term Debt Trading Symbol Trading Symbol Earnings Per Share [Abstract] Collaborative Arrangement Collaborative Arrangement [Member] Total property and equipment Property, Plant and Equipment, Gross 3SBio License License Agreement With Shenyang Sunshine Pharmaceutical Company Limited [Member] Represents information pertaining to License agreement with Shenyang Sunshine Pharmaceutical co., ltd. Exercise price (in dollars per share) Exercise price, beginning balance (in dollars per share) Exercise price, ending balance (in dollars per share) Class of Warrant or Right, Exercise Price of Warrants or Rights Laboratory equipment, software and office equipment Equipment [Member] Number of shares authorized to be sold (in shares) Stock Purchase Program, Number Of Shares Authorized To Be Sold Stock Purchase Program, Number Of Shares Authorized To Be Sold Vested and expected to vest (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number Line of Credit Facility [Table] Line of Credit Facility [Table] Sales of marketable securities Proceeds from Sale of Debt Securities, Available-for-sale Loss contingency accrual Loss Contingency Accrual Term B Loans Term B Loans [Member] Term B Loans Beginning balance (in dollars per share) Ending balance (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Warrants to purchase common stock Warrant liabilities Exercise of warrants Warrant [Member] Contingent Liabilities Contingent Liability Reserve Estimate, Policy [Policy Text Block] Sales milestone payments License And Option Agreement, Sales Milestone Payments That May Be Received License And Option Agreement, Sales Milestone Payments That May Be Received Warrants and rights outstanding, term Warrants and Rights Outstanding, Term Liabilities: Liabilities, Fair Value Disclosure [Abstract] Schedule of Related Party Transactions, by Related Party [Table] Schedule of Related Party Transactions, by Related Party [Table] Issuance of common stock through at-the-market offering, net Stock Issued During Period, Value, Other Total stock-based compensation expense Stock-based compensation expense Share-based Payment Arrangement, Expense Option term License And Option Agreement, Option Term License And Option Agreement, Option Term Sale of stock, percentage of ten-day volume weighted average price of common stock Sale of Stock, Percentage Of Ten-Day Volume Weighted Average Price Of Common Stock Sale of Stock, Percentage Of Ten-Day Volume Weighted Average Price Of Common Stock Entity Current Reporting Status Entity Current Reporting Status Risk-free interest rate Measurement Input, Risk Free Interest Rate [Member] Net loss per share: Earnings Per Share, Basic and Diluted [Abstract] Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Effective income tax rate Effective Income Tax Rate Reconciliation, Percent Amortization of premiums and discounts on marketable securities Accretion (Amortization) of Discounts and Premiums, Investments Share price (in dollars per share) Class of Warrant or Right, Issued to Purchase Common Stock Class of Warrant or Right, Issued to Purchase Common Stock Payables and Accruals [Abstract] Payables and Accruals [Abstract] Construction in process Construction in Progress [Member] Loss on disposal of property and equipment Gain (Loss) on Disposition of Property Plant Equipment Issuance of common stock through at-the-market offering, net (in shares) Stock Issued During Period, Shares, Other Contract assets Contract with Customer, Asset, after Allowance for Credit Loss, Current Cash, cash equivalents, and restricted cash at beginning of period Cash, cash equivalents, and restricted cash at end of period Total cash, cash equivalents, and restricted cash Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Sale of stock, number of shares issued in transaction (in shares) Sale of Stock, Number of Shares Issued in Transaction Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Reclassification of warrant liability to equity upon exercise of warrants Noncash Or Part Noncash, Reclassification Of Warrant Liability To Equity Noncash Or Part Noncash, Reclassification Of Warrant Liability To Equity Statement of Comprehensive Income [Abstract] Statement of Comprehensive Income [Abstract] Income taxes payable Taxes Payable, Current Current assets: Assets, Current [Abstract] Other financing fees Proceeds from (Payments for) Other Financing Activities Debt Instrument, Redemption, Period One Debt Instrument, Redemption, Period One [Member] Total (in shares) Common stock authorized and reserved for future issuance (in shares) Common Stock, Capital Shares Reserved for Future Issuance Leases [Abstract] Leases [Abstract] Income Taxes Income Tax, Policy [Policy Text Block] Impairment of Long-Lived Assets Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block] Net proceeds from issuance of common stock Proceed From Issuance Of Common Stock, Net Proceed From Issuance Of Common Stock, Net Money market funds (included in cash equivalents) Cash and Cash Equivalents, Fair Value Disclosure Entity Address, Postal Zip Code Entity Address, Postal Zip Code Revenue Recognition Revenue from Contract with Customer [Policy Text Block] Issuance of common stock upon exercise of options (in shares) Exercised (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Diluted (in shares) Weighted‑average common shares outstanding—diluted (in shares) Weighted Average Number of Shares Outstanding, Diluted Warrant liabilities Warrant liabilities Warrants and Rights Outstanding Recurring Fair Value, Recurring [Member] Income Taxes Income Tax Disclosure [Text Block] 2008 Plan, 2016 Plan, and 2018 Inducement Incentive Award Plan 2008 Plan, 2016 Plan, and 2018 Inducement Incentive Award Plan [Member] 2008 Plan, 2016 Plan, and 2018 Inducement Incentive Award Plan Research and development Research And Development [Member] Represents the information pertaining to research and development expenses included in the income statement. Related Party [Domain] Related Party [Domain] Summary of Options Activity Share-based Payment Arrangement, Option, Activity [Table Text Block] Spark License Agreement License Agreement Terms [Member] Basis spread on variable rate Debt Instrument, Basis Spread on Variable Rate Estimated penalties and interest Income Tax Examination, Penalties and Interest Expense Equity Stockholders' Equity Note Disclosure [Text Block] Schedule of Potential Common Shares Issuable Upon Conversion of Warrants Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Accrued patent fees Accrued Patent Fees Current Carrying value as of the balance sheet date of patent fees. Fair Value of Financial Instruments Fair Value of Financial Instruments, Policy [Policy Text Block] Non-current liabilities: Other Liabilities, Noncurrent [Abstract] Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Auditor Firm ID Auditor Firm ID Class of Stock [Line Items] Class of Stock [Line Items] Unvested restricted stock units Restricted Stock Units, Unvested [Member] Restricted Stock Units, Unvested Credit Facility [Axis] Credit Facility [Axis] Entity Address, Address Line One Entity Address, Address Line One Net cash used in investing activities Net Cash Provided by (Used in) Investing Activities Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Less accumulated depreciation Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Issuance of common stock under Employee Stock Purchase Plan Stock Issued During Period, Value, Employee Stock Purchase Plan Exercises Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Exercises In Period Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Exercises In Period Debt issuance costs, line of credit arrangements (less than) Debt Issuance Costs, Line of Credit Arrangements, Net Vested in period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value General and administrative General and Administrative Expense [Member] Principles of Consolidation Consolidation, Policy [Policy Text Block] Entity Shell Company Entity Shell Company Expected term Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term Total current liabilities Liabilities, Current Class of Stock [Domain] Class of Stock [Domain] Maximum borrowing capacity Line of Credit Facility, Maximum Borrowing Capacity Money market funds (included in cash equivalents) Money Market Funds [Member] Ownership [Domain] Ownership [Domain] Vested and expected to vest Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value Exercises (in shares) Stock Issued During Period Shares Warrants Exercised Number of warrants exercised during the current period. Current Fiscal Year End Date Current Fiscal Year End Date Less: Debt discount Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net Line of Credit Facility [Line Items] Line of Credit Facility [Line Items] Operating Leased Assets [Line Items] Operating Leased Assets [Line Items] Proceeds from issuance of common stock under Employee Stock Purchase Plan Proceeds from Stock Plans Statement [Table] Statement [Table] Initial upfront execution fee payment License And Option Agreement, Execution Fee Payment License And Option Agreement, Execution Fee Payment Unrealized loss on marketable securities Marketable Securities, Unrealized Gain (Loss) Collaborative Arrangement and Arrangement Other than Collaborative [Table] Collaborative Arrangement and Arrangement Other than Collaborative [Table] Recent Accounting Pronouncements New Accounting Pronouncements, Policy [Policy Text Block] Prepaid Expenses and Other Current Assets Prepaid Expenses and Other Current Assets [Member] Debt Instrument, Redemption, Period [Domain] Debt Instrument, Redemption, Period [Domain] Statistical Measurement [Axis] Statistical Measurement [Axis] Other financing fees Adjustments to Additional Paid in Capital, Other Collaboration and License Agreements Collaboration And License Agreements [Text Block] Collaboration And License Agreements Income tax holiday term Income Tax Holiday Term Income Tax Holiday Term Subsequent Event Subsequent Event [Member] Vested (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Number of Shares Clinical and commercial milestone payment, expected License And Option Agreement, Clinical And Commercial Milestone Payment, Expected License And Option Agreement, Clinical And Commercial Milestone Payment, Expected Expected volatility Measurement Input, Price Volatility [Member] Schedule of Fair Value Measurement Inputs and Valuation Techniques Fair Value Measurement Inputs and Valuation Techniques [Table Text Block] Upfront cash payment License And Option Agreement, Upfront Cash Payment License And Option Agreement, Upfront Cash Payment Warrants and rights outstanding, measurement input Warrants and Rights Outstanding, Measurement Input Initial up-front cash payment License And Option Agreement, Initial Up-Front Cash Payment License And Option Agreement, Initial Up-Front Cash Payment State net operating loss carryforwards Deferred Tax Assets, Operating Loss Carryforwards, State and Local Grant Revenue Grant [Member] Adjustments to reconcile net loss to net cash used in operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Subsequent Event Type [Axis] Subsequent Event Type [Axis] Operating lease cost Operating Lease, Cost Cash and Cash Equivalents [Axis] Cash and Cash Equivalents [Axis] Computer equipment Computer equipment and software Computer Equipment [Member] Related-Party Transactions Related Party Transactions Disclosure [Text Block] Debt Instrument, Redemption, Period [Axis] Debt Instrument, Redemption, Period [Axis] Milestone payment License And Option Agreement, Milestone Payments License And Option Agreement, Milestone Payments Deferred revenue, deductions Contract with Customer, Liability, Deferred Revenue, Revenue Recognized Contract with Customer, Liability, Deferred Revenue, Revenue Recognized Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] Vested and expected to vest, term Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term