Supplemental cash flow information
Supplemental Cash Flow Information [Abstract]
Vested in period (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period
Leasehold improvements
Leasehold Improvements [Member]
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV [Domain]
Net income (loss)
Net income (loss)
Net income (loss)
Net Income (Loss) Attributable to Parent
Right-of-use asset, net
Operating Lease, Right-of-Use Asset
Weighted-average remaining contractual term
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term [Abstract]
n/a
Marketable securities
Debt Securities, Available-for-sale, Current
Preferred stock, shares outstanding (in shares)
Preferred Stock, Shares Outstanding
Payroll and employee related expenses
Employee-related Liabilities, Current
Income Statement Location [Axis]
Income Statement Location [Axis]
Contract liabilities, additions
Contract with Customer, Liability, Increase From Cash Receipts
Contract with Customer, Liability, Increase From Cash Receipts
Schedule of Future Minimum Payments on the Term Loans
Schedule of Maturities of Long-term Debt [Table Text Block]
Valuation technique, option pricing model
Valuation Technique, Option Pricing Model [Member]
Redemption premium
Redemption Premium
Security Exchange Name
Security Exchange Name
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Revenue from Contract with Customer [Abstract]
Revenue from Contract with Customer [Abstract]
Schedule of Changes in Contract Liabilities
Contract with Customer, Contract Asset, Contract Liability, and Receivable [Table Text Block]
Forfeited (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period
Operating lease, weighted average remaining lease term
Operating Lease, Weighted Average Remaining Lease Term
Number of amendments
License and Option Agreement, Number Of Amendments
License and Option Agreement, Number Of Amendments
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Dividend yield
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Number of shares authorized for grants (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Retirement Benefits [Abstract]
Retirement Benefits [Abstract]
Net change in cash, cash equivalents, and restricted cash
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Entity File Number
Entity File Number
Expected volatility
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate
2024
Long-Term Debt, Maturity, Year Two
Schedule of Operating Lease, Lease Income
Operating Lease, Lease Income [Table Text Block]
Accrued external research and development costs
Accrued Research And Development Costs Current
Carrying value as of the balance sheet date of research and development costs.
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Stock-based compensation expense
APIC, Share-based Payment Arrangement, Increase for Cost Recognition
Consulting services expenses (less than)
Related Party Transaction, Expenses from Transactions with Related Party
Income taxes payable
Increase (Decrease) in Income Taxes Payable
Change in fair value
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings
Summary of Available-for-Sale Marketable Securities
Debt Securities, Available-for-sale [Table Text Block]
Subsequent Event Type [Domain]
Subsequent Event Type [Domain]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Valuation Approach and Technique [Domain]
Valuation Approach and Technique [Domain]
Debt amendment fee included in Debt Discount
Payments of Financing Costs
Variable lease cost
Variable Lease, Cost
Operating lease, weighted average discount rate, percent
Operating Lease, Weighted Average Discount Rate, Percent
Total (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Revenue recognized
Contract liabilities, deductions
Contract with Customer, Liability, Revenue Recognized
Sale of Stock [Axis]
Sale of Stock [Axis]
Liability Class [Axis]
Liability Class [Axis]
Subsequent Events [Abstract]
Subsequent Events [Abstract]
Grants in period (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Proceeds from maturities of marketable securities
Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-sale
Unrealized (losses) on marketable securities
Unrealized (losses) on marketable securities
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Award Type [Domain]
Award Type [Domain]
Local Phone Number
Local Phone Number
Credit Facility [Domain]
Credit Facility [Domain]
Assets
Assets [Abstract]
Related Party Transactions [Abstract]
Related Party Transactions [Abstract]
Employment Inducement Incentive Award Plan
Employment Inducement Incentive Award Plan [Member]
Employment Inducement Incentive Award Plan [Member]
2025
Long-Term Debt, Maturity, Year Three
Vested and expected to vest (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Loan payable
Loans Payable, Current
Federal operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Domestic
Vesting period
Defined Contribution Plan Employers Matching Contribution Vesting Period
Period which an employee's right to exercise a plan is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.
Grants in period (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period
Preferred stock, $0.0001 par value; 10,000,000 shares authorized; no shares issued and outstanding at March 31, 2022 and December 31, 2021
Preferred Stock, Value, Issued
Beginning balance (in shares)
Ending balance (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Accumulated deficit
Retained Earnings [Member]
Prepaid expenses, deposits and other assets
Increase (Decrease) in Prepaid Expense and Other Assets
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Accrued interest
Accrued Interest, Current
Accrued Interest, Current
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Related Party [Axis]
Related Party [Axis]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Accounts receivable
Increase (Decrease) in Accounts Receivable
Purchase of property and equipment not yet paid
Capital Expenditures Incurred but Not yet Paid
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Basic (in dollars per share)
Earnings Per Share, Basic
2025
Lessee, Operating Lease, Liability, to be Paid, Year Three
Revenue Arrangements
Revenue from Contract with Customer [Text Block]
Unvested at beginning of period (in shares)
Unvested at end of period (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Fair value as of December 31, 2021
Fair value as of March 31, 2022
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value
2023
Long-Term Debt, Maturity, Year One
Employer contribution made
Defined Contribution Plan, Cost
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Commercial paper
Commercial Paper [Member]
Cash paid for amounts included in the measurement of lease liabilities:
Operating Lease, Payments
Restricted cash and cash equivalents
Restricted Cash and Cash Equivalents
Aggregate amount of upfront and milestone-based payments
Aggregate Amount Of Upfront And Milestone Based Payments Paid
Aggregate Amount Of Upfront And Milestone Based Payments Paid
Laboratory equipment
Laboratory Equipment [Member]
Represents information pertaining to laboratory equipment.
Depreciation and amortization
Other Depreciation and Amortization
Aggregate amount for future payments upon achievement of clinical and regulatory approval milestones for products containing ImmTOR platform
Aggregate Amount For Future Payments Upon Achievement Of Clinical And Regulatory Approval Milestones For Products Containing ImmTOR Platform
Aggregate Amount For Future Payments Upon Achievement Of Clinical And Regulatory Approval Milestones For Products Containing ImmTOR Platform
Series B Preferred Stock Purchase Agreement
Series B Preferred Stock Purchase Agreement [Member]
Series B Preferred Stock Purchase Agreement
Plan Name [Axis]
Plan Name [Axis]
Assets:
Assets, Fair Value Disclosure [Abstract]
Total minimum principal payments
Long-term Debt
Total assets
Assets, Fair Value Disclosure
Level 1
Fair Value, Inputs, Level 1 [Member]
Equity securities, stock purchase agreement, par value per share (in dollars per share)
Equity Securities, Stock Purchase Agreement, Par Value Per Share
Equity Securities, Stock Purchase Agreement, Par Value Per Share
Fair Value by Liability Class [Domain]
Fair Value by Liability Class [Domain]
Income Tax Disclosure [Abstract]
Income Tax Disclosure [Abstract]
Entity Smaller Reporting Company
Entity Small Business
Total liabilities and stockholders’ equity
Liabilities and Equity
Other
Other Accrued Liabilities, Current
Investments, Debt and Equity Securities [Abstract]
Investments, Debt and Equity Securities [Abstract]
Deferred revenue
Short-term contract liability
Contract with Customer, Liability, Current
Exercised (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Additional paid-in capital
Additional Paid in Capital
Underwriting Agreement
Underwriting Agreement [Member]
Underwriting Agreement
Number of obligations
Revenue, Number Of Performance Obligations
Revenue, Number Of Performance Obligations
Liabilities and stockholders’ equity
Liabilities and Equity [Abstract]
Accounts payable
Increase (Decrease) in Accounts Payable
Cash flows from operating activities
Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract]
Net Income (Loss) Per Share
Earnings Per Share [Text Block]
Entity Interactive Data Current
Entity Interactive Data Current
Cash and Cash Equivalents [Domain]
Cash and Cash Equivalents [Domain]
Non-cash interest expense
Paid-in-Kind Interest
Issuance of common stock upon exercise of options
Stock Issued During Period, Value, Stock Options Exercised
Description of the Business
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
MIT
Exclusive Patent License Agreement With Massachusetts Institute Of Technology [Member]
Represents information pertaining to Exclusive patent license agreement with Massachusetts Institute of Technology. "
Term loan facility
Long-term Line of Credit
2024
Lessee, Operating Lease, Liability, to be Paid, Year Two
Effect of exchange rate changes on cash
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents
Total liabilities
Financial and Nonfinancial Liabilities, Fair Value Disclosure
Class of Warrant or Right [Line Items]
Class of Warrant or Right [Line Items]
Schedule of Authorized Shares of Common Stock for Future Issuance
Schedule of Stock by Class [Table Text Block]
Preferred stock, shares authorized (in shares)
Preferred Stock, Shares Authorized
Income Tax Authority [Domain]
Income Tax Authority [Domain]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Unrealized gains
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax
Entity Address, State or Province
Entity Address, State or Province
Non-employee consultants
Non Employee Stock Option [Member]
An arrangement whereby a non-employee is entitled to receive in the future, subject to vesting and other restrictions, a number of shares in the entity at a specified price, as defined in the agreement.
Current liabilities:
Liabilities, Current [Abstract]
Period after first commercial sale when the Company is eligible to receive royalties
Eligible Period To Receive Royalties
Eligible Period To Receive Royalties
Class of Warrant or Right [Table]
Class of Warrant or Right [Table]
Long-term restricted cash
Restricted Cash and Cash Equivalents, Noncurrent
General and administrative
General and Administrative Expense
Estimated forfeitures rate
Share-based Compensation Arrangement By Share-based Payment Award Forfeitures Rate
Represents the percentage of forfeitures rate of the stock options based on the historical trends.
ESPP
Employee Stock Purchase Plan2016 [Member]
Represent information pertaining to the 2016 Employee Stock Purchase Plan.
Debt
Debt Disclosure [Text Block]
Issuance of vested restricted stock units
Stock Issued During Period, Value, Restricted Stock Award, Gross
Stock Incentive Plans
Share-based Payment Arrangement [Text Block]
Level 3
Fair Value, Inputs, Level 3 [Member]
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Accounting Policies [Abstract]
Accounting Policies [Abstract]
Outstanding, term
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
2016 Plan
Stock Incentive Plan2016 [Member]
Represents the information pertaining to the 2016 stock incentive plan, which provides for the granting of stock based awards to employees, directors, and consultants under terms and provisions established by the board of directors.
Operating expenses:
Cost of Revenue [Abstract]
Lease liabilities
Operating Lease, Liability
Document Transition Report
Document Transition Report
Foreign currency transaction, net
Foreign Currency Transaction Gain (Loss), before Tax
Common stock, $0.0001 par value; 200,000,000 shares authorized; 124,380,844 and 123,622,965 shares issued and outstanding as of March 31, 2022 and December 31, 2021, respectively
Common Stock, Value, Issued
Disaggregation of Revenue [Line Items]
Disaggregation of Revenue [Line Items]
Less: Change in fair value of 2019 Warrants
Preferred Stock Dividends and Other Adjustments
Weighted average period for recognition
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unvested at beginning of period (in dollars per share)
Unvested at end of period (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Equity offering costs in accrued liabilities
Equity Offering Costs In Accrued Liabilities
Equity Offering Costs In Accrued Liabilities
Commitments and contingencies
Commitments and Contingencies
Long-term Debt, Fiscal Year Maturity [Abstract]
Long-term Debt, Fiscal Year Maturity [Abstract]
Subsequent Event [Table]
Subsequent Event [Table]
Leases
Lessee, Operating Leases [Text Block]
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax
Entity Emerging Growth Company
Entity Emerging Growth Company
Vested, term
Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Weighted Average Remaining Contractual Term
Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Weighted Average Remaining Contractual Term
Non-cash lease expense
Finance Lease, Right-of-Use Asset, Amortization
2022 (remainder)
Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year
Contract liabilities:
Change In Contract With Customer, Liability [Roll Forward]
Change In Contract With Customer, Liability [Roll Forward]
Ginkgo Agreement
Ginkgo Agreement [Member]
Ginkgo Agreement
Schedule of Weighted Average Assumptions Used
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Ownership [Axis]
Ownership [Axis]
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name [Domain]
Marketable Securities and Investments
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Cover [Abstract]
Cover [Abstract]
Number of claims settled
Loss Contingency, Claims Settled, Number
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Class of warrant or right, outstanding (in shares)
Class of Warrant or Right, Outstanding
Less imputed interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table]
Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table]
Income Tax Authority [Axis]
Income Tax Authority [Axis]
Sale common stock
Sale of Stock, Consideration Received on Transaction
Cash maintained in Russian bank accounts
Cash
Fair value, measurement with unobservable inputs reconciliation, recurring basis, liability, transfers, net
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Transfers, Net
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Financial Instrument [Axis]
Financial Instrument [Axis]
Accrued expenses
Accrued expenses
Accrued Liabilities, Current
Collaboration and license revenue
Revenue from Contract with Customer, Excluding Assessed Tax
Office equipment
Office Equipment [Member]
Numerator:
Net Income (Loss) Available to Common Stockholders, Basic [Abstract]
Outstanding common stock options
Share-based Payment Arrangement, Option [Member]
Equity [Abstract]
Equity [Abstract]
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV [Axis]
Document Quarterly Report
Document Quarterly Report
Measurement Input Type [Domain]
Measurement Input Type [Domain]
Change in fair value of warrant liabilities
Warrant liabilities revaluation
Fair Value Adjustment of Warrants
Common stock
Common Stock [Member]
Operating income (loss)
Operating Income (Loss)
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Table]
Debt Securities, Available-for-sale [Line Items]
Debt Securities, Available-for-sale [Line Items]
Lease liability
Operating Lease, Liability, Current
Unrealized losses
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax
Schedule of Cash and Cash Equivalents [Table]
Schedule of Cash and Cash Equivalents [Table]
Increase (Decrease) in Stockholders' Equity
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Document Fiscal Year Focus
Document Fiscal Year Focus
Property, Plant and Equipment [Abstract]
Property, Plant and Equipment [Abstract]
Stock-based compensation expense
Share-based Payment Arrangement, Noncash Expense
Additional paid-in capital
Additional Paid-in Capital [Member]
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Depreciation expense
Depreciation
Vested
Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Intrinsic Value
Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Intrinsic Value
Weighted-average fair value of common stock (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Weighted Average Fair Value
Weighed-average fair value relating to the share-based payment award.
Purchases of marketable securities
Payments to Acquire Debt Securities, Available-for-sale
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Class of warrant or right, number of securities called by warrants or rights (in shares)
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Deferred revenue, additions
Contract with Customer, Liability, Deferred Revenue, Increase From Cash Receipts
Contract with Customer, Liability, Deferred Revenue, Increase From Cash Receipts
Other income, net
Other Nonoperating Income (Expense)
Contractual payments defined in the Exclusive Patent License agreement
License And Option Agreement, Contractual Payments Made
License And Option Agreement, Contractual Payments Made
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Valuation Approach and Technique [Axis]
Valuation Approach and Technique [Axis]
Takeda Agreement
Takeda Agreement [Member]
Takeda Agreement
Share-based Payment Arrangement [Abstract]
Share-based Payment Arrangement [Abstract]
Total liabilities
Liabilities
Schedule of Accrued Expenses
Schedule of Accrued Liabilities [Table Text Block]
Award Type [Axis]
Award Type [Axis]
Granted (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Outstanding
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Schedule of Lessee, Operating Lease, Liability, Maturity
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
Measurement Input Type [Axis]
Measurement Input Type [Axis]
Total stockholders’ equity
Beginning balance
Ending balance
Stockholders' Equity Attributable to Parent
Common stock, shares issued (in shares)
Common Stock, Shares, Issued
Preferred stock, shares issued (in shares)
Preferred Stock, Shares Issued
City Area Code
City Area Code
Equity securities, stock purchase agreement, purchase price per share (in dollars per share)
Equity Securities, Stock Purchase Agreement, Purchase Price Per Share
Equity Securities, Stock Purchase Agreement, Purchase Price Per Share
Goodwill and Intangible Assets Disclosure [Abstract]
Goodwill and Intangible Assets Disclosure [Abstract]
Expected life (in years)
Measurement Input, Expected Term [Member]
Entity Address, City or Town
Entity Address, City or Town
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Stockholders’ equity:
Stockholders' Equity Attributable to Parent [Abstract]
Noncash investing and financing activities
Noncash Investing and Financing Items [Abstract]
Investment income
Investment Income, Net
Lease liability
Operating Lease, Liability, Noncurrent
Measurement Frequency [Domain]
Measurement Frequency [Domain]
Face value
Debt Instrument, Face Amount
Interest expense
Interest Expense
SOBI Purchase Agreement
SOBI Purchase Agreement [Member]
SOBI Purchase Agreement [Member]
Cost share percentage
Collaborative Arrangement, Cost Share Percentage
Collaborative Arrangement, Cost Share Percentage
Venture debt termination fee
Debt Instrument, Termination Fee
Debt Instrument, Termination Fee
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Shares available for future stock incentive awards
Employee stock option grants
Employees
Share-based Payment Arrangement [Member]
Fair Value Measurement Inputs and Valuation Techniques [Table]
Fair Value Measurement Inputs and Valuation Techniques [Table]
Restricted Stock Units (RSUs)
Restricted Stock Units (RSUs) [Member]
Statement of Stockholders' Equity [Abstract]
Statement of Stockholders' Equity [Abstract]
Issuance of common stock under Employee Stock Purchase Plan (in shares)
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Entity Filer Category
Entity Filer Category
Marketable securities adjusted for other than temporary declines in fair value
Other-than-temporary Impairment Loss, Debt Securities, Available-for-sale
Risk-free interest rate
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Schedule of Restricted Cash and Cash Equivalents
Restrictions on Cash and Cash Equivalents [Table Text Block]
Entity Registrant Name
Entity Registrant Name
Fair value, measurement with unobservable inputs reconciliation, recurring basis, asset, transfers, net
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Transfers, Net
Schedule Of Changes In The Warrant Liabilities
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Proceeds from exercise of stock options
Proceeds from Stock Options Exercised
Future additional payments, expected
License And Option Agreement, Future Additional Payments, Expected
License And Option Agreement, Future Additional Payments, Expected
Issuance of vested restricted stock units (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Gross
Forfeited (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Cash, cash equivalents, restricted cash and marketable securities
Cash, Cash Equivalents, Restricted Cash And Restricted Cash Equivalents And Debt Securities, Available-For-Sale
Cash, Cash Equivalents, Restricted Cash And Restricted Cash Equivalents And Debt Securities, Available-For-Sale
Accounts receivable
Accounts Receivable, after Allowance for Credit Loss, Current
Amendment Flag
Amendment Flag
Underwriting Agreement - 2022 Warrants
Underwriting Agreement - 2022 Warrants [Member]
Underwriting Agreement - 2022 Warrants
Equity Components [Axis]
Equity Components [Axis]
Entity Tax Identification Number
Entity Tax Identification Number
Vested (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Weighted Average Exercise Price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Weighted Average Exercise Price
Fair Value Disclosures [Abstract]
Fair Value Disclosures [Abstract]
Equity securities, stock purchase agreement, shares purchased (in shares)
Equity Securities, Stock Purchase Agreement, Shares Purchased
Equity Securities, Stock Purchase Agreement, Shares Purchased
Antidilutive Securities [Axis]
Antidilutive Securities [Axis]
Document Fiscal Period Focus
Document Fiscal Period Focus
Total current assets
Assets, Current
Disaggregation of Revenue [Table]
Disaggregation of Revenue [Table]
Sale of Stock [Domain]
Sale of Stock [Domain]
Total future minimum lease payments
Lessee, Operating Lease, Liability, to be Paid
Accrued professional and consulting services
Accrued Audit Fees, Current
Accrued Audit Fees, Current
Schedule of Stock by Class [Table]
Schedule of Stock by Class [Table]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Statement of Financial Position [Abstract]
Statement of Financial Position [Abstract]
Unrecognized compensation expense related to unvested employee stock options
Share-based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Less: Current portion of loan payable
Long-term Debt, Current Maturities
Schedule of Stockholders' Equity Note, Warrants or Rights
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset [Domain]
Cash flows from financing activities
Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract]
Schedule of Cash and Cash Equivalents
Schedule of Cash and Cash Equivalents [Table Text Block]
Preferred stock, par value (in dollars per share)
Preferred Stock, Par or Stated Value Per Share
Investments
Equity securities without readily determinable fair value, amount
Equity Securities without Readily Determinable Fair Value, Amount
Unrecognized compensation expense
Share-based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Weighted average grant date fair value of stock options (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Equity Component [Domain]
Equity Component [Domain]
Short-term lease cost
Short-term Lease, Cost
2023
Lessee, Operating Lease, Liability, to be Paid, Year One
Foreign currency translation adjustment
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Shares of common stock issued to employees under the ESPP (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period
Accrued expenses and other liabilities
Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities
Statement [Line Items]
Statement [Line Items]
Deferred revenue
Increase (Decrease) in Contract with Customer, Liability
License and option agreement, written day notice period before cancellation
License And Option Agreement, Written Day Notice Period Before Cancellation
License And Option Agreement, Written Day Notice Period Before Cancellation
Remaining performance obligation
Revenue, Remaining Performance Obligation, Amount
Development milestone
License And Option Agreement, Development Milestone
License And Option Agreement, Development Milestone
Weighted-average exercise price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Sarepta Therapeutics, Inc.
Sarepta Therapeutics, Inc. [Member]
Sarepta Therapeutics, Inc. [Member]
Domestic Tax Authority
Domestic Tax Authority [Member]
Schedule of Stock-Based Compensation
Share-based Payment Arrangement, Cost by Plan [Table Text Block]
Fair value
Marketable securities:
Debt Securities, Available-for-sale
2026
Lessee, Operating Lease, Liability, to be Paid, Year Four
Debt Disclosure [Abstract]
Debt Disclosure [Abstract]
Founders
Founder [Member]
Represents information pertaining to founder member.
Disclosure of Share-based Compensation Arrangements by Share-based Payment Award
Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]
Number of shares authorized, increase (in shares)
Share-Based Compensation Arrangement By Share-Based Payment Award, Number Of Shares Available For Grant, Increase (Decrease)
Share-Based Compensation Arrangement By Share-Based Payment Award, Number Of Shares Available For Grant, Increase (Decrease)
Level 2
Fair Value, Inputs, Level 2 [Member]
Deferred revenue, beginning of period
Deferred revenue, end of period
Contract with Customer, Liability, Deferred Revenue
Contract with Customer, Liability, Deferred Revenue
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset [Axis]
Subsidiary, Sale of Stock [Line Items]
Subsidiary, Sale of Stock [Line Items]
Dividend yield
Measurement Input, Expected Dividend Rate [Member]
Deferred revenue
Long-term contract liability
Contract with Customer, Liability, Noncurrent
Amortized cost
Debt Securities, Available-for-sale, Amortized Cost
Loan payable, net of current portion
Loans Payable, Noncurrent
Defined Contribution Plan
Retirement Benefits [Text Block]
Granted (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Computation of Basic and Diluted Net Loss Per Share
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Aggregate intrinsic value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value [Abstract]
n/a
Title of 12(b) Security
Title of 12(b) Security
Net proceeds from issuance of common stock
Shares issued, value
Proceeds from Issuance of Common Stock
Total assets
Assets
Plan Name [Domain]
Plan Name [Domain]
Common stock, shares authorized (in shares)
Common Stock, Shares Authorized
Cash paid for interest
Interest Paid, Excluding Capitalized Interest, Operating Activities
Adjusted net income (loss)
Net Income (Loss) Available to Common Stockholders, Diluted
Geographical [Domain]
Geographical [Domain]
Adjusted net income (loss)
Net Income (Loss) Available to Common Stockholders, Basic
Document Type
Document Type
Accrued Expenses
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Research and development
Research and Development Expense
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Measurement Frequency [Axis]
Measurement Frequency [Axis]
Net cash (used in) operating activities
Net Cash Provided by (Used in) Operating Activities
Schedule of Term Loan And Unamortized Debt Discount Balances
Schedule of Debt [Table Text Block]
Furniture and fixtures
Furniture and Fixtures [Member]
Fair Value, Recurring and Nonrecurring [Table]
Fair Value, Recurring and Nonrecurring [Table]
Schedule of Long-term Debt Instruments [Table]
Schedule of Long-term Debt Instruments [Table]
Schedule of Lease, Cost
Lease, Cost [Table Text Block]
Corporate bonds
Corporate Bond Securities [Member]
Cash and Cash Equivalents [Line Items]
Cash and Cash Equivalents [Line Items]
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Net income (loss) per share:
Earnings Per Share, Basic [Abstract]
Geographical [Axis]
Geographical [Axis]
Basic (in shares)
Weighted-average common shares outstanding, basic (in shares)
Weighted Average Number of Shares Outstanding, Basic
Diluted (in dollars per share)
Earnings Per Share, Diluted
Share price (in dollars per share)
Sale of Stock, Price Per Share
Dilutive effect of employee equity incentive plans and outstanding warrants (in shares)
Weighted Average Number Diluted Shares Outstanding Adjustment
Russian subsidiary
RUSSIAN FEDERATION
Subsequent Events
Subsequent Events [Text Block]
Total comprehensive income (loss)
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Deferred revenue related to agreement
Contract liabilities, beginning of period
Contract liabilities, end of period
Contract with Customer, Liability
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Weighted average common shares outstanding:
Denominator:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Award vesting term
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
AskBio License
AskBio License [Member]
AskBio License [Member]
Fair Value Measurements
Fair Value Disclosures [Text Block]
Accounts payable
Accounts Payable, Current
Summary of Assets Measured at Fair Value on a Recurring Basis
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Accumulated other comprehensive loss
AOCI Attributable to Parent [Member]
Other assets
Other Assets
Common stock, shares outstanding (in shares)
Beginning balance (in shares)
Ending balance (in shares)
Common Stock, Shares, Outstanding
Financial Instruments [Domain]
Financial Instruments [Domain]
Other comprehensive income (loss):
Other Comprehensive Income (Loss), Tax [Abstract]
Document Period End Date
Document Period End Date
Entity Central Index Key
Entity Central Index Key
Potential common shares
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Number of Options
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Cyrus Biotechnology, Inc.
Cyrus Biotechnology, Inc. [Member]
Cyrus Biotechnology, Inc.
Cash flows from investing activities
Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract]
Total lease cost
Lease, Cost
Schedule of Property and Equipment
Property, Plant and Equipment [Table Text Block]
Research and development credits
Deferred Tax Assets, Tax Credit Carryforwards, Research
Income Statement Location [Domain]
Income Statement Location [Domain]
At-The-Market Offering
At-The-Market Offering [Member]
At-The-Market Offering [Member]
Debt Securities, Available-for-sale [Table]
Debt Securities, Available-for-sale [Table]
License Agreement For Pompe Disease
License Agreement For Pompe Disease [Member]
License Agreement For Pompe Disease [Member]
2020 Term Loans
2020 Term Loans [Member]
2020 Term Loans
Property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Net
Property and Equipment
Property, Plant and Equipment Disclosure [Text Block]
Total operating expenses
Collaboration expense
Operating Expenses
License and option agreement, payments made relative to calculated premium paid for initial equity investment made under the purchase agreement
License And Option Agreement, Calculated Premium Paid For Equity Investment Under Purchase Agreement
License And Option Agreement, Calculated Premium Paid For Equity Investment Under Purchase Agreement
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Trading Symbol
Trading Symbol
Earnings Per Share [Abstract]
Collaborative Arrangement
Collaborative Arrangement [Member]
Total property and equipment
Property, Plant and Equipment, Gross
3SBio License
License Agreement With Shenyang Sunshine Pharmaceutical Company Limited [Member]
Represents information pertaining to License agreement with Shenyang Sunshine Pharmaceutical co., ltd.
Exercise price (in dollars per share)
Class of Warrant or Right, Exercise Price of Warrants or Rights
Vested and expected to vest (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Line of Credit Facility [Table]
Line of Credit Facility [Table]
Loss contingency accrual
Loss Contingency Accrual
Beginning balance (in dollars per share)
Ending balance (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Warrants to purchase common stock
Warrant liabilities
Exercise of warrants
Warrant [Member]
Sales milestone payments
License And Option Agreement, Sales Milestone Payments That May Be Received
License And Option Agreement, Sales Milestone Payments That May Be Received
Warrants and rights outstanding, term
Warrants and Rights Outstanding, Term
Liabilities:
Liabilities, Fair Value Disclosure [Abstract]
Schedule of Related Party Transactions, by Related Party [Table]
Schedule of Related Party Transactions, by Related Party [Table]
Issuance of common stock through at-the-market offering, net
Stock Issued During Period, Value, Other
Total stock-based compensation expense
Stock-based compensation expense
Share-based Payment Arrangement, Expense
Option term
License And Option Agreement, Option Term
License And Option Agreement, Option Term
Entity Current Reporting Status
Entity Current Reporting Status
Risk-free interest rate
Measurement Input, Risk Free Interest Rate [Member]
Net income (loss) per share:
Earnings Per Share, Basic and Diluted [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Amortization of premiums and discounts on marketable securities
Accretion (Amortization) of Discounts and Premiums, Investments
Payables and Accruals [Abstract]
Payables and Accruals [Abstract]
Construction in process
Construction in Progress [Member]
(Gain) on disposal of property and equipment
Gain (Loss) on Disposition of Property Plant Equipment
Issuance of common stock through at-the-market offering, net (in shares)
Stock Issued During Period, Shares, Other
Cash, cash equivalents, and restricted cash at beginning of period
Cash, cash equivalents, and restricted cash at end of period
Total cash, cash equivalents, and restricted cash
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents
Sale of stock, number of shares issued in transaction (in shares)
Sale of Stock, Number of Shares Issued in Transaction
Common stock, par value (in dollars per share)
Common Stock, Par or Stated Value Per Share
Statement of Comprehensive Income [Abstract]
Statement of Comprehensive Income [Abstract]
Income taxes payable
Taxes Payable, Current
Current assets:
Assets, Current [Abstract]
Total (in shares)
Common stock authorized and reserved for future issuance (in shares)
Common Stock, Capital Shares Reserved for Future Issuance
Leases [Abstract]
Leases [Abstract]
Money market funds (included in cash equivalents)
Cash and Cash Equivalents, Fair Value Disclosure
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Issuance of common stock upon exercise of options (in shares)
Exercised (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Diluted (in shares)
Weighted‑average common shares outstanding—diluted (in shares)
Weighted Average Number of Shares Outstanding, Diluted
Warrant liabilities
Warrant liabilities
Warrants and Rights Outstanding
Recurring
Fair Value, Recurring [Member]
Income Taxes
Income Tax Disclosure [Text Block]
2008 Plan, 2016 Plan, and 2018 Inducement Incentive Award Plan
2008 Plan, 2016 Plan, and 2018 Inducement Incentive Award Plan [Member]
2008 Plan, 2016 Plan, and 2018 Inducement Incentive Award Plan
Research and development
Research And Development [Member]
Represents the information pertaining to research and development expenses included in the income statement.
Related Party [Domain]
Related Party [Domain]
Summary of Options Activity
Share-based Payment Arrangement, Option, Activity [Table Text Block]
Spark License Agreement
License Agreement Terms [Member]
Equity
Stockholders' Equity Note Disclosure [Text Block]
Schedule of Potential Common Shares Issuable Upon Conversion of Warrants
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Accrued patent fees
Accrued Patent Fees Current
Carrying value as of the balance sheet date of patent fees.
Non-current liabilities:
Other Liabilities, Noncurrent [Abstract]
Statement of Cash Flows [Abstract]
Statement of Cash Flows [Abstract]
Class of Stock [Line Items]
Class of Stock [Line Items]
Unvested restricted stock units
Restricted Stock Units, Unvested [Member]
Restricted Stock Units, Unvested
Credit Facility [Axis]
Credit Facility [Axis]
Entity Address, Address Line One
Entity Address, Address Line One
Net cash provided by (used in) investing activities
Net Cash Provided by (Used in) Investing Activities
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Less accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Issuance of common stock under Employee Stock Purchase Plan
Stock Issued During Period, Value, Employee Stock Purchase Plan
Vested in period (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
General and administrative
General and Administrative Expense [Member]
Entity Shell Company
Entity Shell Company
Expected term
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Total current liabilities
Liabilities, Current
Thereafter
Lessee, Operating Lease, Liability, To Be Paid, After Year Four
Lessee, Operating Lease, Liability, To Be Paid, After Year Four
Money market funds (included in cash equivalents)
Money Market Funds [Member]
Ownership [Domain]
Ownership [Domain]
Vested and expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Current Fiscal Year End Date
Current Fiscal Year End Date
Less: Debt discount
Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net
Line of Credit Facility [Line Items]
Line of Credit Facility [Line Items]
Proceeds from issuance of common stock under Employee Stock Purchase Plan
Proceeds from Stock Plans
Statement [Table]
Statement [Table]
Initial upfront execution fee payment
License And Option Agreement, Execution Fee Payment
License And Option Agreement, Execution Fee Payment
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Recent Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Other financing fees
Adjustments to Additional Paid in Capital, Other
Collaboration and License Agreements
Collaboration And License Agreements [Text Block]
Collaboration And License Agreements
Subsequent Event
Subsequent Event [Member]
Vested (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Number of Shares
Clinical and commercial milestone payment, expected
License And Option Agreement, Clinical And Commercial Milestone Payment, Expected
License And Option Agreement, Clinical And Commercial Milestone Payment, Expected
Expected volatility
Measurement Input, Price Volatility [Member]
Schedule of Fair Value Measurement Inputs and Valuation Techniques
Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]
Upfront cash payment
License And Option Agreement, Upfront Cash Payment
License And Option Agreement, Upfront Cash Payment
Warrants and rights outstanding, measurement input
Warrants and Rights Outstanding, Measurement Input
Initial up-front cash payment
License And Option Agreement, Initial Up-Front Cash Payment
License And Option Agreement, Initial Up-Front Cash Payment
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Subsequent Event Type [Axis]
Subsequent Event Type [Axis]
Operating lease cost
Operating Lease, Cost
Computer equipment and software
Computer Equipment [Member]
Cash and Cash Equivalents [Axis]
Cash and Cash Equivalents [Axis]
Related-party Transactions
Related Party Transactions Disclosure [Text Block]
Debt discount
Debt Instrument, Unamortized Discount
Milestone payment
License And Option Agreement, Milestone Payments
License And Option Agreement, Milestone Payments
Deferred revenue, deductions
Contract with Customer, Liability, Deferred Revenue, Revenue Recognized
Contract with Customer, Liability, Deferred Revenue, Revenue Recognized
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Vested and expected to vest, term
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term