Commitments and Contingencies Disclosure [Abstract]
Schedule of Future Minimum Lease Payments
Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block]
Equity [Abstract]
Schedule of Stock by Class [Table]
Schedule of Stock by Class [Table]
Equity Components [Axis]
Equity Components [Axis]
Equity Component [Domain]
Equity Component [Domain]
Exercise of common warrants
Warrant [Member]
Award Type [Axis]
Award Type [Axis]
Equity Award [Domain]
Equity Award [Domain]
Shares available for future stock incentive awards
Stock Compensation Plan [Member]
Outstanding common stock options
Employee Stock Option [Member]
Class of Stock [Line Items]
Class of Stock [Line Items]
Total (in shares)
Common Stock, Capital Shares Reserved for Future Issuance
Debt Disclosure [Abstract]
Schedule of Future Minimum Payments on the Term Loans
Schedule of Maturities of Long-term Debt [Table Text Block]
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]
Fair Value Disclosures [Abstract]
Fair Value Measurements, Recurring and Nonrecurring [Table]
Fair Value Measurements, Recurring and Nonrecurring [Table]
Range [Axis]
Range [Axis]
Range [Domain]
Range [Domain]
Minimum
Minimum [Member]
Major Types of Debt and Equity Securities [Axis]
Major Types of Debt and Equity Securities [Axis]
Major Types of Debt and Equity Securities [Domain]
Major Types of Debt and Equity Securities [Domain]
U.S. government and agency securities
US Treasury and Government [Member]
Commercial paper
Commercial Paper [Member]
Corporate Bonds
Corporate Bond Securities [Member]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Tri-party repurchase agreements collateralized by government securities (not less than) (as a percent)
Cash And Cash Equivalents Collateralized By Government Securities, Value Of Collateral, Percent Of Fair Value
Cash And Cash Equivalents Collateralized By Government Securities, Value Of Collateral, Percent Of Fair Value
Average maturity, term
Investments Maturity Period
Represents information pertaining to US treasury obligations in investments maturity period.
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table]
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table]
Income Statement Location [Axis]
Income Statement Location [Axis]
Income Statement Location [Domain]
Income Statement Location [Domain]
Research and development
Research And Development [Member]
Represents the information pertaining to research and development expenses included in the income statement.
General and administrative
General and Administrative Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total stock-based compensation expense
Allocated Share-based Compensation Expense
Statement of Financial Position [Abstract]
Assets
Assets [Abstract]
Current assets:
Assets, Current [Abstract]
Cash, cash equivalents, and restricted cash
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Current
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Current
Short-term deposits and investments
Short-term Investments
Accounts receivable
Accounts Receivable, Net, Current
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Total current assets
Assets, Current
Property and equipment, net
Property, Plant and Equipment, Net
Restricted cash and other assets
Restricted Cash and Investments, Noncurrent
Total assets
Assets
Liabilities and stockholders’ equity
Liabilities and Equity [Abstract]
Current liabilities:
Liabilities, Current [Abstract]
Accounts payable
Accounts Payable, Current
Accrued expenses
Accrued Liabilities, Current
Deferred revenue, current portion
Contract With Customer, Liability, Deferred Revenue, Current
Contract With Customer, Liability, Deferred Revenue, Current
Total current liabilities
Liabilities, Current
Non‑current liabilities:
Other Liabilities, Noncurrent [Abstract]
Deferred rent and lease incentive
Deferred Rent Credit, Noncurrent
Loans payable, net of current portion
Loans Payable, Noncurrent
Deferred revenue, net of current portion
Contract With Customer, Liability, Deferred Revenue, Noncurrent
Contract With Customer, Liability, Deferred Revenue, Noncurrent
Other long‑term liabilities
Other Liabilities, Noncurrent
Total liabilities
Liabilities
Commitments and contingencies (Notes 8 and 12)
Commitments and Contingencies
Stockholders’ equity:
Stockholders' Equity Attributable to Parent [Abstract]
Preferred stock, $0.0001 par value; 10,000,000 shares authorized; no shares issued and outstanding at March 31, 2018 and December 31, 2017, respectively
Preferred Stock, Value, Issued
Common stock, $0.0001 par value; 200,000,000 shares authorized; 22,349,840 and 22,343,254 shares issued and outstanding as of March 31, 2018 and December 31, 2017, respectively
Common Stock, Value, Issued
Additional paid-in capital
Additional Paid in Capital
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax
Total stockholders’ equity
Stockholders' Equity Attributable to Parent
Total liabilities and stockholders’ equity
Liabilities and Equity
Fair Value Measurements
Fair Value Disclosures [Text Block]
Investments, Debt and Equity Securities [Abstract]
Summary of Available-for-Sale Marketable Securities
Schedule of Available-for-sale Securities Reconciliation [Table Text Block]
Schedule of Fair Values and Amortized Cost of Marketable Debt Securities by Contractual Maturity
Investments Classified by Contractual Maturity Date [Table Text Block]
Payables and Accruals [Abstract]
Accrued Expenses
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Goodwill and Intangible Assets Disclosure [Abstract]
Technology License Agreements
Technology License Agreements [Text Block]
The entire disclosure for technology license agreements.
Retirement Benefits [Abstract]
Defined Contribution Plan
Pension and Other Postretirement Benefits Disclosure [Text Block]
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Debt
Debt Disclosure [Text Block]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Plan Name [Axis]
Plan Name [Axis]
Plan Name [Domain]
Plan Name [Domain]
ESPP
Employee Stock Purchase Plan2016 [Member]
Represent information pertaining to the 2016 Employee Stock Purchase Plan.
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of offering periods under the ESPP
Number Of Offering Periods
Number Of Offering Periods
Term of each offering period
Offering Period
Offering Period
Eligible compensation withheld for use (up to) (as a percent)
Share-based Compensation Arrangement by Share-based Payment Award, Maximum Employee Subscription Rate
Purchase price of shares (not less than) (as a percent)
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent
Common stock authorized and reserved for future issuance (in shares)
Number of shares of common stock outstanding (as a percent)
Employee Stock Purchase Plan Maximum Percentage Of Shares Reserved Based On Shares Outstanding
The maximum percentage increase in the shares reserved for future issuance each year based on the number of common stock outstanding at the last day of the year.
Number of shares authorized, increase (in shares)
Share-Based Compensation Arrangement By Share-Based Payment Award, Number Of Shares Available For Grant, Increase (Decrease)
Share-Based Compensation Arrangement By Share-Based Payment Award, Number Of Shares Available For Grant, Increase (Decrease)
Shares of common stock issued to employees under the ESPP (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period
Stock-based compensation expense
Property, Plant and Equipment [Abstract]
Schedule of Property and Equipment
Property, Plant and Equipment [Table Text Block]
Accounting Policies [Abstract]
Number of operating segments
Number of Operating Segments
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Accumulated deficit
Schedule of Cash and Cash Equivalents [Table]
Schedule of Cash and Cash Equivalents [Table]
Geographical [Axis]
Geographical [Axis]
Geographical [Domain]
Geographical [Domain]
Russian subsidiary
RUSSIAN FEDERATION
Cash and Cash Equivalents [Axis]
Cash and Cash Equivalents [Axis]
Cash and Cash Equivalents [Domain]
Cash and Cash Equivalents [Domain]
Unrestricted cash
Unrestricted Cash [Member]
Unrestricted Cash [Member]
Cash and Cash Equivalents [Line Items]
Cash and Cash Equivalents [Line Items]
Cash, cash equivalents, and restricted cash
Cash and Cash Equivalents, at Carrying Value
Measurement Frequency [Axis]
Measurement Frequency [Axis]
Fair Value, Measurement Frequency [Domain]
Fair Value, Measurement Frequency [Domain]
Recurring
Fair Value, Measurements, Recurring [Member]
Money market funds
Money Market Funds [Member]
Corporate bonds
Corporate Debt Securities [Member]
Corporate bonds
Fair Value, Hierarchy [Axis]
Fair Value, Hierarchy [Axis]
Fair Value Hierarchy [Domain]
Fair Value Hierarchy [Domain]
(Level 1)
Fair Value, Inputs, Level 1 [Member]
(Level 2)
Fair Value, Inputs, Level 2 [Member]
(Level 3)
Fair Value, Inputs, Level 3 [Member]
Total cash equivalents
Cash and Cash Equivalents, Fair Value Disclosure
Total short-term investments
Investments, Fair Value Disclosure
Statement of Cash Flows [Abstract]
Cash flows from operating activities
Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract]
Net loss
Net Income (Loss) Attributable to Parent
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Depreciation
Depreciation
Amortization of premiums and accretion of discounts on investments
Accretion (Amortization) of Discounts and Premiums, Investments
Stock‑based compensation expense
Non‑cash interest expense
Paid-in-Kind Interest
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Accounts receivable
Increase (Decrease) in Accounts Receivable
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
Accounts payable
Increase (Decrease) in Accounts Payable
Deferred revenue
Increase (Decrease) in Deferred Revenue
Accrued expenses and other liabilities
Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Cash flows from investing activities
Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract]
Receipts from the maturity of investments
Proceeds from Maturities, Prepayments and Calls of Short-term Investments
Purchase of short-term investments
Payments to Acquire Short-term Investments
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Net cash provided by (used in) investing activities
Net Cash Provided by (Used in) Investing Activities
Cash flows from financing activities
Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract]
Repayments of long-term debt
Repayments of Long-term Debt
Proceeds from exercise of stock options
Proceeds from Stock Options Exercised
Proceeds from issuance of common stock under Employee Stock Purchase Plan
Proceeds from Stock Plans
Net cash provided by (used in) financing activities
Net Cash Provided by (Used in) Financing Activities
Effect of exchange rate changes on cash
Effect of Exchange Rate on Cash and Cash Equivalents
Net decrease in cash, cash equivalents, and restricted cash
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Cash, cash equivalents, and restricted cash at beginning of period
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents
Cash, cash equivalents, and restricted cash at end of period
Supplement cash flow information
Supplemental Cash Flow Information [Abstract]
Cash paid for interest
Interest Paid
Noncash investing activities
Noncash Investing and Financing Items [Abstract]
Purchase of property and equipment not yet paid
Capital Expenditures Incurred but Not yet Paid
Unrealized gain on marketable securities
Marketable Securities, Unrealized Gain (Loss)
Summary of Assets Measured at Fair Value on a Recurring Basis
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Table]
Property, Plant and Equipment, Type [Axis]
Property, Plant and Equipment, Type [Axis]
Property, Plant and Equipment, Type [Domain]
Property, Plant and Equipment, Type [Domain]
Laboratory equipment
Laboratory Equipment [Member]
Represents information pertaining to laboratory equipment.
Computer equipment and software
Computer Equipment [Member]
Leasehold improvements
Leasehold Improvements [Member]
Furniture and fixtures
Furniture and Fixtures [Member]
Office equipment
Office Equipment [Member]
Construction in process
Construction in Progress [Member]
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Total property and equipment
Property, Plant and Equipment, Gross
Less accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Property and equipment, net
Income Tax Holiday [Table]
Income Tax Holiday [Table]
Income Tax Authority [Axis]
Income Tax Authority [Axis]
Income Tax Authority [Domain]
Income Tax Authority [Domain]
Russia
Foreign Tax Authority [Member]
Income Tax Authority, Name [Axis]
Income Tax Authority, Name [Axis]
Income Tax Authority, Name [Domain]
Income Tax Authority, Name [Domain]
Russian Federal Tax Service
Russian Federal Tax Service [Member]
Russian Federal Tax Service [Member]
Income Tax Holiday [Line Items]
Income Tax Holiday [Line Items]
Current income tax expense or benefit
Current Income Tax Expense (Benefit)
Deferred income tax expense or benefit
Deferred Income Tax Expense (Benefit)
Term of tax holiday granted to Russian subsidiary
Income Tax Holiday, Term
Income Tax Holiday, Term
Tax Cuts and Jobs Act, reduction of deferred tax assets
Tax Cuts and Jobs Act, Change in Tax Rate, Increase (Decrease) In Deferred Tax Asset
Tax Cuts and Jobs Act, Change in Tax Rate, Increase (Decrease) In Deferred Tax Asset
Full valuation allowance
Tax Cuts and Jobs Act, Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Tax Cuts and Jobs Act, Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Unrecognized tax benefits
Unrecognized Tax Benefits
Related interest and penalties accrued
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued
Accrued interest related to uncertain tax positions
Unrecognized Tax Benefits, Interest on Income Taxes Accrued
Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table]
Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table]
Type of Arrangement and Non-arrangement Transactions [Axis]
Type of Arrangement and Non-arrangement Transactions [Axis]
Arrangements and Non-arrangement Transactions [Domain]
Arrangements and Non-arrangement Transactions [Domain]
MIT
Exclusive Patent License Agreement With Massachusetts Institute Of Technology [Member]
Represents information pertaining to Exclusive patent license agreement with Massachusetts Institute of Technology.
"
Maximum
Maximum [Member]
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Spark License Agreement
License Agreement Terms [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percentage of sublicense income
Percentage Of Sublicense Income
Represents information pertaining to percentage of sublicense income.
Payment amount upon achievement of defined clinical milestones
Payment Amount Upon Achievement Of Defined Clinical Milestones
Represents information pertaining to payment amount upon achievement of defined clinical milestones.
Contractual payments defined in the Exclusive Patent License agreement
License And Option Agreement, Contractual Payments Made
License And Option Agreement, Contractual Payments Made
License and option agreement, payments made relative to calculated premium paid for initial equity investment made under the purchase agreement
License And Option Agreement, Calculated Premium Paid For Equity Investment Under Purchase Agreement
License And Option Agreement, Calculated Premium Paid For Equity Investment Under Purchase Agreement
Fair Value
Available-for-sale Securities, Debt Maturities, Fair Value, Fiscal Year Maturity [Abstract]
Less than one year
Available-for-sale Securities, Debt Maturities, Next Twelve Months, Fair Value
Amortized Cost
Available-for-sale Securities, Debt Maturities, Amortized Cost Basis, Fiscal Year Maturity [Abstract]
Less than one year
Available-for-sale Securities, Debt Maturities, Next Twelve Months, Amortized Cost Basis
Schedule of Weighted Average Assumptions Used for Stock Option Grants
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Summary of Activity Under the 2008 Plan and the 2016 Plan
Share-based Compensation, Stock Options, Activity [Table Text Block]
Schedule of Stock-Based Compensation Expense Related to Stock Options and Restricted Common Stock
Schedule of Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Table Text Block]
Property and Equipment
Property, Plant and Equipment Disclosure [Text Block]
Effective interest rate for debt arrangement
Debt Instrument, Interest Rate, Effective Percentage
Earnings Per Share [Abstract]
Numerator:
Net Income (Loss) Available to Common Stockholders, Basic [Abstract]
Denominator:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Weighted‑average common shares outstanding—basic and diluted (in shares)
Weighted Average Number of Shares Outstanding, Basic and Diluted
Net loss per share attributable to common stockholders—basic and diluted (in dollars per share)
Earnings Per Share, Basic and Diluted
Document and Entity Information
Document Type
Document Type
Amendment Flag
Amendment Flag
Document Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Filer Category
Entity Filer Category
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
The 2008 Plan and the 2016 Plan
The 2008 Plan And The 2016 Plan [Member]
The 2008 Plan And The 2016 Plan [Member]
Employee Awards
Non‑Employee Awards
Non Employee Stock Option [Member]
An arrangement whereby a non-employee is entitled to receive in the future, subject to vesting and other restrictions, a number of shares in the entity at a specified price, as defined in the agreement.
Number of Options
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Beginning balance (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Granted (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Exercised (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Forfeited (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period
Ending balance (in shares)
Vested (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Number of Shares
Vested and expected to vest (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Weighted-average exercise price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Beginning balance (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Granted (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Exercised (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Forfeited (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Ending balance (in dollars per share)
Vested (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Weighted Average Exercise Price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Weighted Average Exercise Price
Vested and expected to vest (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Weighted-average remaining contractual term
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term [Abstract]
n/a
Outstanding, term
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Vested, term
Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Weighted Average Remaining Contractual Term
Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Weighted Average Remaining Contractual Term
Vested and expected to vest, term
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Aggregate intrinsic value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value [Abstract]
n/a
Outstanding
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Vested
Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Intrinsic Value
Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Intrinsic Value
Vested and expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Revenue from Contract with Customer [Abstract]
Schedule of Impact of New Accounting Pronouncements
Schedule of New Accounting Pronouncements and Changes in Accounting Principles [Table Text Block]
Schedule of Changes in Contract Liabilities
Contract with Customer, Asset and Liability [Table Text Block]
Vesting period
Defined Contribution Plan Employers Matching Contribution Vesting Period
Period which an employee's right to exercise a plan is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.
Employer contribution made
Defined Contribution Plan, Cost
Remaining performance obligation
Revenue, Remaining Performance Obligation
Remaining performance obligation, percentage
Revenue, Remaining Performance Obligation, Percentage
Revenue, Remaining Performance Obligation, Percentage
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Table]
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Table]
License and Supply Obligation
License And Supply Obligation [Member]
License And Supply Obligation [Member]
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Remaining performance obligation, period
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period
Stock Incentive Plans
Disclosure of Compensation Related Costs, Share-based Payments [Text Block]
Title of Individual [Axis]
Title of Individual [Axis]
Relationship to Entity [Domain]
Relationship to Entity [Domain]
Chief Executive Officer
Chief Executive Officer [Member]
Vesting [Axis]
Vesting [Axis]
Vesting [Domain]
Vesting [Domain]
Tranche One
Share-based Compensation Award, Tranche One [Member]
Tranche Two
Share-based Compensation Award, Tranche Two [Member]
2008 Plan
Stock Incentive Plan2008 [Member]
Represents the information pertaining to the 2008 stock incentive plan, which provides for the granting of stock based awards to employees, directors, and consultants under terms and provisions established by the board of directors.
2016 Plan
Stock Incentive Plan2016 [Member]
Represents the information pertaining to the 2016 stock incentive plan, which provides for the granting of stock based awards to employees, directors, and consultants under terms and provisions established by the board of directors.
Non-employee stock options
Number of shares authorized for grants (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Exercise price of incentive stock options (not less than)
Combined voting power of participants (as a percent)
Share-based Compensation Arrangement By Share-based Payment Award, Voting Rights of Common Stock, Holding Percentage
Represents the percentage of voting rights of all classes of stock held by the employees.
Award vesting term
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
Award expiration term
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period
Automatic increase in the number of shares that may be issued (as a percent)
Number of shares available for future grants (in shares)
Estimated forfeitures rate
Share-based Compensation Arrangement By Share-based Payment Award Forfeitures Rate
Represents the percentage of forfeitures rate of the stock options based on the historical trends.
Weighted average grant date fair value of stock options (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Shares exercises in period by employees (in shares)
Aggregate intrinsic value of stock options exercised
Unrecognized compensation expense related to unvested employee stock options
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options
Weighted average period for recognition
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition
Unvested stock option awards (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Number of Shares
Forfeited (in shares)
Unrecognized compensation expense related to unvested non-employee stock options
Share-Based Goods And Non Employee Services Transaction, Compensation Not Yet Recognized, Stock Options
Share-Based Goods And Non Employee Services Transaction, Compensation Not Yet Recognized, Stock Options
Depreciation expense
Schedule of Available-for-sale Securities [Table]
Schedule of Available-for-sale Securities [Table]
Financial Instrument [Axis]
Financial Instrument [Axis]
Financial Instruments [Domain]
Financial Instruments [Domain]
Corporate bonds
Schedule of Available-for-sale Securities [Line Items]
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost
Available-for-sale Debt Securities, Amortized Cost Basis
Gross Unrealized Gains
Available-for-sale Debt Securities, Accumulated Gross Unrealized Gain, before Tax
Gross Unrealized Losses
Available-for-sale Debt Securities, Accumulated Gross Unrealized Loss, before Tax
Estimated Fair Value
Available-for-sale Securities, Debt Securities
Agreements collateralized by U.S. treasury securities (no less than) (as a percent)
Realized gains or losses on sale of investments
Realized Investment Gains (Losses)
Available-for-Sale Marketable Securities
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Antidilutive Securities [Axis]
Antidilutive Securities [Axis]
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name [Domain]
Stock options to purchase common stock
Stock warrants to purchase common stock
Potential common shares
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Related Party Transactions [Abstract]
Schedule of Related Party Transactions, by Related Party [Table]
Schedule of Related Party Transactions, by Related Party [Table]
Sale of Stock [Axis]
Sale of Stock [Axis]
Sale of Stock [Domain]
Sale of Stock [Domain]
Springer Purchase Agreement
Springer Purchase Agreement [Member]
Springer Purchase Agreement [Member]
Related Party [Axis]
Related Party [Axis]
Related Party [Domain]
Related Party [Domain]
Founders
Founder [Member]
Represents information pertaining to founder member.
Class of Stock [Axis]
Class of Stock [Axis]
Class of Stock [Domain]
Class of Stock [Domain]
Series D Redeemable Convertible Preferred Stock
Series D Redeemable Convertible Preferred Stock [Member]
Represents information pertaining to series D redeemable convertible preferred stock.
Conversion of Series E Preferred
Series E Redeemable Convertible Preferred Stock [Member]
Represents information pertaining to series E redeemable convertible preferred stock.
Common stock
Common Stock [Member]
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Stock issued (in shares)
Stock Issued During Period, Shares, New Issues
Share price (in dollars per share)
Sale of Stock, Price Per Share
Sale of stock, number of shares issued in transaction (in shares)
Sale of Stock, Number of Shares Issued in Transaction
Exercise price (in dollars per share)
Class of Warrant or Right, Exercise Price of Warrants or Rights
Expiration period of warrants
Class Of Warrants Or Rights, Term
Period of time between issuance and maturity of warrant, in PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.
Share price (in dollars per share)
Class of Warrant or Right, Issued to Purchase Common Stock
Class of Warrant or Right, Issued to Purchase Common Stock
Expenses for consulting services (less than)
Related Party Transaction, Expenses from Transactions with Related Party
Principles of Consolidation
Consolidation, Policy [Policy Text Block]
Foreign Currency
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Segment Information
Segment Reporting, Policy [Policy Text Block]
Cash Equivalents and Short Term Investments
Cash Equivalents And Short Term Investments [Policy Text Block]
Disclosure of accounting policy for cash equivalents and short term investments.
Concentrations of Credit Risk and Off-Balance Sheet Risk
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Fair Value of Financial Instruments
Fair Value of Financial Instruments, Policy [Policy Text Block]
Property and Equipment
Property, Plant and Equipment, Policy [Policy Text Block]
Impairment of Long-Lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Debt Issuance Costs
Debt, Policy [Policy Text Block]
Accumulated Other Comprehensive Income (Loss)
Comprehensive Income, Policy [Policy Text Block]
Revenue Recognition
Revenue Recognition, Policy [Policy Text Block]
Research and Development Costs
Research and Development Expense, Policy [Policy Text Block]
Clinical Trial Costs
Clinical Trial Costs [Policy Text Block]
Disclosure of accounting policy for clinical trial costs.
Income Taxes
Income Tax, Policy [Policy Text Block]
Warrants
Warrants [Policy Text Block]
Disclosure of accounting policy for warrants.
Stock-Based Compensation
Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block]
Net Loss Per Share
Earnings Per Share, Policy [Policy Text Block]
Deferred Rent
Deferred Rent [Policy Text Block]
Disclosure of accounting policy for deferred rent.
Contingent Liabilities
Contingent Liability Reserve Estimate, Policy [Policy Text Block]
Recent Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Computation of Basic and Diluted Net Loss Per Share
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Schedule of Potential Common Shares Issuable Upon Conversion of Warrants
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Nature of the Business and Basis of Presentation
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Line of Credit Facility [Table]
Line of Credit Facility [Table]
Credit Facility [Axis]
Credit Facility [Axis]
Credit Facility [Domain]
Credit Facility [Domain]
2017 Term Loans
2017 Term Loans [Member]
2017 Term Loans [Member]
Line of Credit Facility [Line Items]
Line of Credit Facility [Line Items]
Year ended December 31,
Long-term Debt, Fiscal Year Maturity [Abstract]
2018 (Remainder)
Long-term Debt, Maturities, Repayments of Principal, Remainder of Fiscal Year
2019
Long-term Debt, Maturities, Repayments of Principal in Year Two
2020
Long-term Debt, Maturities, Repayments of Principal in Year Three
2021
Long-term Debt, Maturities, Repayments of Principal in Year Four
2022
Long-term Debt, Maturities, Repayments of Principal in Year Five
Total minimum debt payments
Long-term Debt
Less: Amount representing interest
Debt Instrument Interest Portion
The interest portion of gross outstanding debt.
Less: Debt discount and deferred charges
Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net
Less: Current portion of loans payable
Long-term Debt, Current Maturities
Loans payable, net of current portion
Long-term Debt, Excluding Current Maturities
3SBio License
License Agreement With Shenyang Sunshine Pharmaceutical Company Limited [Member]
Represents information pertaining to License agreement with Shenyang Sunshine Pharmaceutical co., ltd.
Period after approval to commercialize product
Period For Commercialization Of Product
Represents information pertaining to period for commercialization of product.
Aggregate amount of upfront and milestone-based payments
Aggregate Amount Of Upfront And Milestone Based Payments Paid
Aggregate Amount Of Upfront And Milestone Based Payments Paid
Additional liability for milestone payments expensed in 2016
Upfront And Milestone Based Payments, Additional Liability
Upfront And Milestone Based Payments, Additional Liability
Aggregate amount for future payments upon achievement of clinical and regulatory approval milestones for products containing SVP technology
Aggregate Amount For Future Payments Upon Achievement Of Clinical And Regulatory Approval Milestones For Products Containing Svp Technology
Represents information pertaining to aggregate amount for future payments upon achievement of clinical and regulatory approval milestones for product containing SVP technology.
Aggregate amount for future payments upon achievement of clinical and regulatory approval milestones for products without SVP technology
Aggregate Amount For Future Payments Upon Achievement Of Clinical And Regulatory Approval Milestones For Products Without Svp Technology
Represents information pertaining to aggregate amount for future payments upon achievement of clinical and regulatory approval milestones for product without SVP technology.
Maximum paid on tiered royalties (percent)
Maximum Percentage Paid On Tiered Royalties
Maximum Percentage Paid On Tiered Royalties
Period for prior written notice to terminate license
Period For Prior Written Notice To Terminate License
Represents information pertaining to period for prior written notice to terminate license.
MEE
License Agreement With Massachusetts Eye And Ear Infirmary And Schepens Eye Research Institute Inc. [Member]
Represents information pertaining to License agreement with Massachusetts Eye and Ear Infirmary and The Schepens Eye Research Institute, Inc.
Minimum number of products for each target sequence
Number Of Products Marketed And Sold
Represents the number of products the Company has agreed to market and sell for each target sequence for which the Company exercised its option as soon as reasonably practicable.
Payment under development milestone method
Development Milestone Method, Amount Paid
The amount of consideration paid during the period for the development milestone or milestones.
Payment under sales milestone method
Sales Milestone Method, Amount Paid
The amount of consideration paid during the period for the sales milestone or milestones.
License fees due under agreement
Initial License Fee Paid
Initial License Fee Paid
Accrued License Fees
Accrued License Fees
Accrued License Fees
Stockholders' Equity
Stockholders' Equity Note Disclosure [Text Block]
Schedule of Cash and Cash Equivalents
Schedule of Cash and Cash Equivalents [Table Text Block]
Schedule of Restricted Cash and Cash Equivalents
Restrictions on Cash and Cash Equivalents [Table Text Block]
Components of Accumulated Other Comprehensive Income (Loss), Net of Tax
Schedule of Accumulated Other Comprehensive Income (Loss) [Table Text Block]
Revenue, Initial Application Period Cumulative Effect Transition [Table]
Revenue, Initial Application Period Cumulative Effect Transition [Table]
Initial Application Period Cumulative Effect Transition [Axis]
Initial Application Period Cumulative Effect Transition [Axis]
Initial Application Period Cumulative Effect Transition [Domain]
Initial Application Period Cumulative Effect Transition [Domain]
Pro forma as if the previous accounting was in effect
Calculated under Revenue Guidance in Effect before Topic 606 [Member]
Adjustments due to ASU 2014-09
Difference between Revenue Guidance in Effect before and after Topic 606 [Member]
Adjustments for New Accounting Pronouncements [Axis]
Adjustments for New Accounting Pronouncements [Axis]
Type of Adoption [Domain]
Type of Adoption [Domain]
ASU 2014-09
Accounting Standards Update 2014-09 [Member]
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Common stock
Year ended December 31,
Operating Leases, Future Minimum Payments Due, Fiscal Year Maturity [Abstract]
2018 (remainder)
Operating Leases, Future Minimum Payments, Remainder of Fiscal Year
2019
Operating Leases, Future Minimum Payments, Due in Two Years
2020
Operating Leases, Future Minimum Payments, Due in Three Years
Total minimum lease payments
Operating Leases, Future Minimum Payments Due
Preferred stock, par value (in dollars per share)
Preferred Stock, Par or Stated Value Per Share
Preferred stock, shares authorized
Preferred Stock, Shares Authorized
Preferred stock, shares issued
Preferred Stock, Shares Issued
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding
Common stock, par value (in dollars per share)
Common Stock, Par or Stated Value Per Share
Common stock, shares authorized
Common Stock, Shares Authorized
Common stock, shares issued
Common Stock, Shares, Issued
Common stock, shares outstanding
Common Stock, Shares, Outstanding
Disaggregation of Revenue [Table]
Disaggregation of Revenue [Table]
Accumulated deficit
Retained Earnings [Member]
Project [Axis]
Project [Axis]
Project [Domain]
Project [Domain]
First Grant
First Grant [Member]
Represents information pertaining to first grant under NIH.
First Acquisition Right
First Acquisition Right [Member]
First Acquisition Right [Member]
Skolkovo
Russia Vased Development Fund Of New Technologies Development And Commercialization Center Grant Agreement [Member]
Represents information pertaining to russi vased development fund of new technologies development and commercialization center grant agreement.
Second Acquisition Right
Second Acquisition Right [Member]
Second Acquisition Right [Member]
NIH
National Institutes Of Health Grant Agreement [Member]
Represents information pertaining to national institutes of health grant agreement.
Spark Letter Agreement
Spark Letter Agreement [Member]
Spark Letter Agreement [Member]
Consideration for Promises
Consideration For Promises [Member]
Consideration For Promises [Member]
Development Milestones
Development Milestones [Member]
Development Milestones [Member]
Regulatory Milestones
Regulatory Milestones [Member]
Regulatory Milestones [Member]
Commercial Milestones
Commercial Milestones [Member]
Commercial Milestones [Member]
Discount on Option Obligation
Discount On Option Obligation [Member]
Discount On Option Obligation [Member]
Disaggregation of Revenue [Line Items]
Disaggregation of Revenue [Line Items]
Number of collaboration/grant agreements that required analysis to quantify the impact of adoption
Number Of Collaboration Agreements Under Analysis To Quantify Impact Of Adoption
Number Of Collaboration Agreements Under Analysis To Quantify Impact Of Adoption
Upfront cash payment
License And Option Agreement, Upfront Cash Payment
License And Option Agreement, Upfront Cash Payment
Aggregate additional payments due within twelve months
License And Option Agreement, Aggregate Additional Payments Due Within Twelve Months Of Contract Date
License And Option Agreement, Aggregate Additional Payments Due Within Twelve Months Of Contract Date
Term loan number of payments
Term Loan Number of Payments
Term Loan Number of Payments
Two payments due within 12 months of contract date
License And Option Agreement, Two Payments Due Within Twelve Months Of Contract Date
License And Option Agreement, Two Payments Due Within Twelve Months Of Contract Date
Number of additional targets
License And Option Agreement, Number Of Additional Targets For Which Other Party May Exercise Options For Additional Licenses
License And Option Agreement, Number Of Additional Targets For Which Other Party May Exercise Options For Additional Licenses
Variable fee the Company is eligible to receive for each additional target option elected
License And Option Agreement, Variable Fee To Be Received For Each Additional Target Option Elected
License And Option Agreement, Variable Fee To Be Received For Each Additional Target Option Elected
Election period to exercise additional targets
License And Option Agreement, Period For Other Party To Exercise Options For Additional Licenses
License And Option Agreement, Period For Other Party To Exercise Options For Additional Licenses
Additional development and regulatory milestone payments
License And Option Agreement, Additional Development And Regulatory Milestone Payments That May Be Received
License And Option Agreement, Additional Development And Regulatory Milestone Payments That May Be Received
Commercialization milestone payments
License And Option Agreement, Commercialization Milestone Payments That May Be Received
License And Option Agreement, Commercialization Milestone Payments That May Be Received
Sales milestone payments
License And Option Agreement, Sales Milestone Payments That May Be Received
License And Option Agreement, Sales Milestone Payments That May Be Received
Number of obligations
Revenue, Number Of Performance Obligations
Revenue, Number Of Performance Obligations
Period after first commercial sale when the Company is eligible to receive royalties
Eligible Period To Receive Royalties
Eligible Period To Receive Royalties
Period for prior written notice to terminate license
Sale common stock
Sale of Stock, Consideration Received on Transaction
Premium of average daily VWAP (as a percent)
Premium Of Average Daily Volume Weighted Average Price Of Common Stock, Percent
Premium Of Average Daily Volume Weighted Average Price Of Common Stock, Percent
Contract liability
Contract with Customer, Liability
Consecutive calendar days leading up to and ending on the day prior to the Contract Date
Consecutive Calendar Days Leading Up To Contract Date
Consecutive Calendar Days Leading Up To Contract Date
Aggregate purchase price
Aggregate Purchase Price
Aggregate Purchase Price
Aggregate price of shares Spark will have the right to purchase
Stock Purchase Agreement, Authorized Amount Of Stock To Sell
Stock Purchase Agreement, Authorized Amount Of Stock To Sell
Number of shares authorized to be issued pursuant to the Stock Purchase Agreement (in shares)
Stock Purchase Program, Number Of Shares Authorized To Be Sold
Stock Purchase Program, Number Of Shares Authorized To Be Sold
License and option agreement, additional sub-license payment received liability
License And Option Agreement, Additional Sub-License Payment Received Liability
License And Option Agreement, Additional Sub-License Payment Received Liability
Number of agreements combined and evaluated into a single agreement
Number Of Agreements Combined Into Single Agreement For Evaluation
Number Of Agreements Combined Into Single Agreement For Evaluation
Fair value of initial purchase of common stock combined with the embedded future stock Acquisition Rights
Stock Issued During Period, Value, Purchase of Assets
Performance obligation per each option
Revenue, Remaining Performance Obligation, Each Option
Revenue, Remaining Performance Obligation, Each Option
Incremental costs of obtaining a contract
Capitalized Contract Cost, Net
Revenue recognized
Contract with Customer, Liability, Deferred Revenue, Revenue Recognized
Contract with Customer, Liability, Deferred Revenue, Revenue Recognized
Deferred revenue related to agreement
Contract with Customer, Liability, Deferred Revenue
Contract with Customer, Liability, Deferred Revenue
Aggregate purchase price per share (in dollar per share)
Stock Purchase Program, Aggregate Purchase Price Per Share
Stock Purchase Program, Aggregate Purchase Price Per Share
Aggregate amount of grant
Grants From Entities Amount Of Grant Award
Represents information pertaining to aggregate amount of grant.
Percentage of estimated total cost of research plan
Percentage Of Estimated Cost Of Research Plan
Represents information pertaining to percentage of estimated cost of research plan.
Remaining percentage of estimated costs to be contributed by the Company
Remaining Percentage Contributed By The Entity
Represents information pertaining to remaining percentage contributed by the entity.
Payments received
Increase Decrease In Contingently Repayable Grant Funding
The increase (decrease) during the reporting period in contingently repayable grant funding that are used in an entity's business.
Cumulative effect adjustment
Cumulative Effect of New Accounting Principle in Period of Adoption
Period after completion of project when Company may be required to reimburse the funds received
Period To Audit Expenditure Incurred
Represents information pertaining to period to audit expenditure incurred.
Revenue recognized
Revenue from Grants
Remaining amount not recognized
Grant Revenue, Available Under Grant Not Recognized
Grant Revenue, Available Under Grant Not Recognized
Payroll and employee related expenses
Employee-related Liabilities, Current
Current portion of deferred rent and lease incentive
Accrued Rent And Lease Incentive Payable Current
" Carrying value as of the balance sheet date of obligations incurred through that date and payable for contractual rent under lease arrangements and an incentive or inducement contractually stipulated between parties to a lease whereby the lessor has committed to provide the entity (lessee) with a cash payment as inducement to enter the lease. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer)."
Collaboration and licensing
Accrued Collaboration and Licensing
Accrued Collaboration and Licensing
Accrued patent fees
Accrued Patent Fees Current
Carrying value as of the balance sheet date of patent fees.
Accrued external research and development costs
Accrued Research And Development Costs Current
Carrying value as of the balance sheet date of research and development costs.
Accrued professional and consulting services
Accrued Audit Fees, Current
Accrued Audit Fees, Current
Accrued grant refund
Accrued Grant Refund, Current
Accrued Grant Refund, Current
Accrued interest
Interest Payable, Current
Other
Other Accrued Liabilities, Current
Accrued expenses
Laboratory and office equipment
Equipment [Member]
Computer equipment
Estimated useful life
Property, Plant and Equipment, Useful Life
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Number of investment position in an unrealized loss position, less than twelve months
Debt Securities, Available-For-Sale, Continuous Unrealized Loss Position, Less Than 12 Months, Number Of Positions
Debt Securities, Available-For-Sale, Continuous Unrealized Loss Position, Less Than 12 Months, Number Of Positions
Fair value investments, unrealized loss position, less than twelve months
Debt Securities, Available-For-Sale, Continuous Unrealized Loss Position, Less Than 12 Months
Debt Securities, Available-For-Sale, Continuous Unrealized Loss Position, Less Than 12 Months
Unrealized loss through net loss (less than)
Available-for-sale Debt Securities, Gross Unrealized Loss
Other-than-temporary impairments
Other than Temporary Impairment Losses, Investments, Available-for-sale Securities
Revenue from Contracts with Customers
Revenue from Contract with Customer [Text Block]
Employee stock option grants
Risk-free interest rate
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Dividend yield
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected term
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Expected volatility
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Weighted-average fair value of common stock (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Weighted Average Fair Value
Weighed-average fair value relating to the share-based payment award.
Related-Party Transactions
Related Party Transactions Disclosure [Text Block]
Net Loss Per Share
Earnings Per Share [Text Block]
Schedule of Operating Leased Assets [Table]
Schedule of Operating Leased Assets [Table]
Lease Arrangement, Type [Axis]
Lease Arrangement, Type [Axis]
Lease Arrangement, Type [Domain]
Lease Arrangement, Type [Domain]
Laboratory and office space
Laboratory And Office Space [Member]
Represents information pertaining to laboratory and office space member.
Balance Sheet Location [Axis]
Balance Sheet Location [Axis]
Balance Sheet Location [Domain]
Balance Sheet Location [Domain]
Restricted cash and other assets
Restricted Cash And Other Deposits [Member]
Represents inforamtion pertaining to restricted cash and other deposits member.
Accrued expenses
Accounts Payable and Accrued Liabilities [Member]
Letter of credit
Letter of Credit [Member]
Operating Leased Assets [Line Items]
Operating Leased Assets [Line Items]
Tenant improvement allowance
Payments for (Proceeds from) Tenant Allowance
Letter of credit
Line of Credit Facility, Maximum Borrowing Capacity
Area of additional office space leased
Area of Real Estate Property
Deferred rent and lease incentive liability
Deferred Rent And Lease Incentive Liability
This element represents both current and non current costs incurred by the lessor that are (a) costs to originate a lease incurred in transactions with independent third parties that (i) result directly from and are essential to acquire that lease and (ii) would not have been incurred had that leasing transaction not occurred and (b) certain costs directly related to specified activities performed by the lessor for that lease and includes the deferred charge for an incentive or inducement granted by a lessor to a lessee, in order to motivate the lessee to enter the lease agreement, which incentive or inducement is to be recognized as a reduction of rental revenue over the lease term.
Current portion of deferred rent and lease incentive liability (less than)
Rent expense
Operating Leases, Rent Expense, Net
Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table]
Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table]
At-The-Market Offering
At-The-Market Offering [Member]
At-The-Market Offering [Member]
2017 PIPE
2017 PIPE [Member]
2017 PIPE [Member]
IPO
IPO [Member]
Over-Allotment Option
Over-Allotment Option [Member]
Subsidiary, Sale of Stock [Line Items]
Subsidiary, Sale of Stock [Line Items]
Public securities offering, amount authorized
Public Securities Offering, Amount Authorized
Public Securities Offering, Amount Authorized
Public stock offering, amount authorized
Public Stock Offering, Amount Authorized
Public Stock Offering, Amount Authorized
Proceeds from issuance of common stock
Proceeds from Issuance of Common Stock
Proceeds from Initial Public Offering, net of underwriters' discounts and commissions
Proceeds from Issuance Initial Public Offering
Common stock issued for convertible preferred stock (in shares)
Convertible Preferred Stock, Shares Issued upon Conversion
Common stock, shares authorized (in shares)
Number of votes per share that common stockholders are entitled to
Votes Per Share of Common Stock
Votes Per Share of Common Stock
Dividends declared or paid on common stock
Dividends, Common Stock
Common stock, shares outstanding (in shares)
Concentration Risk [Table]
Concentration Risk [Table]
Russian subsidiary
Currency [Axis]
Currency [Axis]
All Currencies [Domain]
All Currencies [Domain]
U.S. dollars
United States of America, Dollars
Concentration Risk [Line Items]
Concentration Risk [Line Items]
Cash maintained in Russian bank accounts
Cash
Variable Rate [Axis]
Variable Rate [Axis]
Variable Rate [Domain]
Variable Rate [Domain]
Prime rate
Base Rate [Member]
Term Loans
Term Loan [Member]
Represents information pertaining to term loan member.
Long-term Debt, Type [Axis]
Long-term Debt, Type [Axis]
Long-term Debt, Type [Domain]
Long-term Debt, Type [Domain]
Convertible Debt
Convertible Debt [Member]
Debt Covenant Period [Axis]
Debt Covenant Period [Axis]
Debt Covenant Period [Axis]
Debt Covenant Period [Domain]
Debt Covenant Period [Domain]
[Domain] for Debt Covenant Period [Axis]
Prepaid before the first anniversary
Term Loan Prepaid Before the First Anniversary [Member]
Term Loan Prepaid Before the First Anniversary [Member]
Prepaid after to first anniversary but before second
Term Loan Prepaid After First Anniversary But Before Second Anniversary [Member]
Represents information pertaining to prepayment of term loan after first anniversary but prior to second anniversary.
Prepaid after second anniversary
Term Loan Prepaid After Second Anniversary [Member]
Represents information pertaining to prepayment of term loan after second anniversary.
Conversion of Series D Preferred
Borrowing capacity
Borrowings on loan and security agreement
Proceeds from Lines of Credit
Interest rate per annum
Line of Credit Facility, Interest Rate During Period
Number of monthly installments
Debt Instrument, Term
Prepayment fee (as a percent)
Early Extinguishment Of Debt, Prepayment Fee Percentage
Percentage of fee payable on early extinguishment of debt.
Final payment fee (as a percent)
Final Payment Fee Percentage
Percentage of final fee payment payable on aggregate principal amounts borrowed.
Final payment fee
Debt Instrument, Periodic Payment Terms, Balloon Payment to be Paid
Warrants issued for purchase of stock (in shares)
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Initial grant date fair value of warrants
Warrants, Grant Date Fair Value
Represents the initial grant date fair value of the warrants.
Number of warrants exercised to purchase common stock (in shares)
Number Of Warrants Exercised To Purchase Common Stock
Number Of Warrants Exercised To Purchase Common Stock
Net shares of common stock issued (in shares)
Stock Issued During Period, Shares, Common Stock Issued Upon Exercise Of Warrants
Stock Issued During Period, Shares, Common Stock Issued Upon Exercise Of Warrants
Term loan facility
Long-term Line of Credit
Repayments of debt
Repayments of Lines of Credit
Loss on extinguishment of debt
Gain (Loss) on Extinguishment of Debt
Debt issuance costs, line of credit arrangements (less than)
Debt Issuance Costs, Line of Credit Arrangements, Net
Floating rate
Debt Instrument, Basis Spread on Variable Rate
Minimum assets trigger
Debt Instrument, Event Of Default, Minimum Assets Trigger
Debt Instrument, Event Of Default, Minimum Assets Trigger
Minimum amount in excess of indebtedness trigger
Debt Instrument, Event Of Default, Minimum Amount In Excess Of Indebtedness Trigger
Debt Instrument, Event Of Default, Minimum Amount In Excess Of Indebtedness Trigger
Interest expense related to the Term Loan
Interest Expense
Schedule of Accrued Expenses
Schedule of Accrued Liabilities [Table Text Block]
Accumulated Other Comprehensive Income (Loss) [Table]
Accumulated Other Comprehensive Income (Loss) [Table]
Foreign currency translation adjustment
Accumulated Foreign Currency Adjustment Attributable to Parent [Member]
Unrealized gains (losses) on available-for-sale securities
Accumulated Net Investment Gain (Loss) Attributable to Parent [Member]
Accumulated other comprehensive income (loss)
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Accumulated Other Comprehensive Income (Loss) [Line Items]
AOCI Attributable to Parent, Net of Tax
AOCI Attributable to Parent, Net of Tax [Roll Forward]
Beginning balance
Other comprehensive loss during the year
Other Comprehensive Income (Loss), Net of Tax
Ending balance
Contract liabilities:
Change In Contract With Customer, Liability [Roll Forward]
Change In Contract With Customer, Liability [Roll Forward]
Deferred revenue, beginning of period
Other liabilities, beginning of period
Contract with Customer, Liability, Other
Contract with Customer, Liability, Other
Contract liabilities, beginning of period
Deferred revenue, additions
Contract with Customer, Liability, Deferred Revenue, Increase From Cash Receipts
Contract with Customer, Liability, Deferred Revenue, Increase From Cash Receipts
Other liabilities, additions
Contract with Customer, Liability, Other, Increase From Cash Receipts
Contract with Customer, Liability, Other, Increase From Cash Receipts
Contract liabilities, additions
Contract with Customer, Liability, Increase From Cash Receipts
Contract with Customer, Liability, Increase From Cash Receipts
Deferred revenue, deductions
Other liabilities, deductions
Contract with Customer, Liability, Other, Revenue Recognized
Contract with Customer, Liability, Other, Revenue Recognized
Contract liabilities, deductions
Contract with Customer, Liability, Revenue Recognized
Deferred revenue, end of period
Other liabilities, end of period
Contract liabilities, end of period
Other liabilities, current portion
Contract with Customer, Liability, Other, Current
Contract with Customer, Liability, Other, Current
Other liabilities, noncurrent portion
Contract with Customer, Liability, Other, Noncurrent
Contract with Customer, Liability, Other, Noncurrent
Statement of Comprehensive Income [Abstract]
Grant and collaboration revenue
Revenues
Operating expenses:
Cost of Revenue [Abstract]
Research and development
Research and Development Expense
General and administrative
General and Administrative Expense
Total operating expenses
Operating Expenses
Loss from operations
Operating Income (Loss)
Investment income
Investment Income, Net
Loss on extinguishment of debt
Foreign currency transaction gain (loss), net
Foreign Currency Transaction Gain (Loss), before Tax
Interest expense
Net loss
Other comprehensive loss:
Other Comprehensive Income (Loss), Tax [Abstract]
Foreign currency translation adjustment
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax
Unrealized gain on securities
Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax
Total comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Net loss attributable to common stockholders
Net Income (Loss) Available to Common Stockholders, Basic
Net loss per share attributable to common stockholders:
Earnings Per Share, Basic and Diluted [Abstract]
Weighted average common shares outstanding:
Basic and diluted (in shares)
Schedule of Authorized Shares of Common Stock for Future Issuance
Schedule of Stock by Class [Table Text Block]
Restricted cash
Restricted Cash and Cash Equivalents, Current
Restricted cash included in other assets
Restricted Cash and Cash Equivalents, Noncurrent
Total cash, cash equivalents, and restricted cash shown in the consolidated statement of cash flows