1001 - Document - Cover Page link:presentationLink link:definitionLink link:calculationLink 1002 - Statement - Consolidated Balance Sheets link:presentationLink link:definitionLink link:calculationLink 1003 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:definitionLink link:calculationLink 1004 - Statement - Consolidated Statements of Operations and Comprehensive Income (Loss) link:presentationLink link:definitionLink link:calculationLink 1005 - Statement - Consolidated Statements of Changes in Stockholders' Equity (Deficit) link:presentationLink link:definitionLink link:calculationLink 1006 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:definitionLink link:calculationLink 1007 - Disclosure - Description of the Business link:presentationLink link:definitionLink link:calculationLink 1008 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:definitionLink link:calculationLink 1009 - Disclosure - Marketable Securities and Investments link:presentationLink link:definitionLink link:calculationLink 1010 - Disclosure - Net (Loss) Income Per Share link:presentationLink link:definitionLink link:calculationLink 1011 - Disclosure - Fair Value Measurements link:presentationLink link:definitionLink link:calculationLink 1012 - Disclosure - Property and Equipment link:presentationLink link:definitionLink link:calculationLink 1013 - Disclosure - Accrued Expenses link:presentationLink link:definitionLink link:calculationLink 1014 - Disclosure - Leases link:presentationLink link:definitionLink link:calculationLink 1015 - Disclosure - Debt link:presentationLink link:definitionLink link:calculationLink 1016 - Disclosure - Equity link:presentationLink link:definitionLink link:calculationLink 1017 - Disclosure - Stock Incentive Plans link:presentationLink link:definitionLink link:calculationLink 1018 - Disclosure - Revenue Arrangements link:presentationLink link:definitionLink link:calculationLink 1019 - Disclosure - Related-party Transactions link:presentationLink link:definitionLink link:calculationLink 1020 - Disclosure - Collaboration and License Agreements link:presentationLink link:definitionLink link:calculationLink 1021 - Disclosure - Income Taxes link:presentationLink link:definitionLink link:calculationLink 1022 - Disclosure - Defined Contribution Plan link:presentationLink link:definitionLink link:calculationLink 1023 - Disclosure - Commitments and Contingencies link:presentationLink link:definitionLink link:calculationLink 1024 - Disclosure - Subsequent Events link:presentationLink link:definitionLink link:calculationLink 1025 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:definitionLink link:calculationLink 1026 - Disclosure - Marketable Securities and Investments (Tables) link:presentationLink link:definitionLink link:calculationLink 1027 - Disclosure - Net (Loss) Income Per Share (Tables) link:presentationLink link:definitionLink link:calculationLink 1028 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:definitionLink link:calculationLink 1029 - Disclosure - Property and Equipment (Tables) link:presentationLink link:definitionLink link:calculationLink 1030 - Disclosure - Accrued Expenses (Tables) link:presentationLink link:definitionLink link:calculationLink 1031 - Disclosure - Leases (Tables) link:presentationLink link:definitionLink link:calculationLink 1032 - Disclosure - Equity (Tables) link:presentationLink link:definitionLink link:calculationLink 1033 - Disclosure - Stock Incentive Plans (Tables) link:presentationLink link:definitionLink link:calculationLink 1034 - Disclosure - Revenue Arrangements (Tables) link:presentationLink link:definitionLink link:calculationLink 1035 - Disclosure - Related-party Transactions (Tables) link:presentationLink link:definitionLink link:calculationLink 1036 - Disclosure - Description of the Business (Details) link:presentationLink link:definitionLink link:calculationLink 1037 - Disclosure - Marketable Securities and Investments - Summary of Available-for-Sale Marketable Securities (Details) link:presentationLink link:definitionLink link:calculationLink 1038 - Disclosure - Marketable Securities and Investments - Narrative (Details) link:presentationLink link:definitionLink link:calculationLink 1039 - Disclosure - Net (Loss) Income Per Share - Computation of Basic and Diluted Net Income (Loss) Per Share (Details) link:presentationLink link:definitionLink link:calculationLink 1040 - Disclosure - Net (Loss) Income Per Share - Schedule of Potential Common Shares Issuable Upon Conversion of Warrants (Details) link:presentationLink link:definitionLink link:calculationLink 1041 - Disclosure - Fair Value Measurements - Schedule of Assets Measured at Fair Value on a Recurring Basis (Details) link:presentationLink link:definitionLink link:calculationLink 1042 - Disclosure - Fair Value Measurements - Narrative (Details) link:presentationLink link:definitionLink link:calculationLink 1043 - Disclosure - Fair Value Measurements - Schedule of Cash and Cash Equivalents (Details) link:presentationLink link:definitionLink link:calculationLink 1044 - Disclosure - Fair Value Measurements - Assumptions Used to Record the Fair Value of the Warrants (Details) link:presentationLink link:definitionLink link:calculationLink 1045 - Disclosure - Fair Value Measurements - Change in the Warrant Liabilities (Details) link:presentationLink link:definitionLink link:calculationLink 1046 - Disclosure - Property and Equipment - Schedule of Property and Equipment (Details) link:presentationLink link:definitionLink link:calculationLink 1047 - Disclosure - Property and Equipment - Narrative (Details) link:presentationLink link:definitionLink link:calculationLink 1048 - Disclosure - Accrued Expenses (Details) link:presentationLink link:definitionLink link:calculationLink 1049 - Disclosure - Leases - Components of Lease Costs (Details) link:presentationLink link:definitionLink link:calculationLink 1050 - Disclosure - Leases - Operating Lease, Liability, Maturity (Details) link:presentationLink link:definitionLink link:calculationLink 1051 - Disclosure - Leases - Other Information (Details) link:presentationLink link:definitionLink link:calculationLink 1052 - Disclosure - Leases - Lease Term and Discount Rate (Details) link:presentationLink link:definitionLink link:calculationLink 1053 - Disclosure - Leases - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1054 - Disclosure - Debt - Term Loans (Narrative) (Details) link:presentationLink link:definitionLink link:calculationLink 1055 - Disclosure - Equity - Narrative (Details) link:presentationLink link:definitionLink link:calculationLink 1056 - Disclosure - Equity - Warranty Activity (Details) link:presentationLink link:definitionLink link:calculationLink 1057 - Disclosure - Equity - Schedule of Authorized Shares of Common Stock for Future Issuance (Details) link:presentationLink link:definitionLink link:calculationLink 1058 - Disclosure - Stock Incentive Plans - Narrative (Details) link:presentationLink link:definitionLink link:calculationLink 1059 - Disclosure - Stock Incentive Plans - Schedule of Stock-Based Compensation Expense Related to Stock Options and Restricted Common Stock (Details) link:presentationLink link:definitionLink link:calculationLink 1060 - Disclosure - Stock Incentive Plans - Schedule of Assumptions (Details) link:presentationLink link:definitionLink link:calculationLink 1061 - Disclosure - Stock Incentive Plans - Schedule of Options Activity (Details) link:presentationLink link:definitionLink link:calculationLink 1062 - Disclosure - Stock Incentive Plans - Restricted Stock Units (Details) link:presentationLink link:definitionLink link:calculationLink 1063 - Disclosure - Stock Incentive Plans - Employee Stock Purchase Plan (Narrative) (Details) link:presentationLink link:definitionLink link:calculationLink 1064 - Disclosure - Revenue Arrangements - Narrative (Details) link:presentationLink link:definitionLink link:calculationLink 1065 - Disclosure - Revenue Arrangements - Schedule of Changes in Contract Liabilities (Details) link:presentationLink link:definitionLink link:calculationLink 1066 - Disclosure - Related-party Transactions - Number of Shares of Common Stock Purchased (Details) link:presentationLink link:definitionLink link:calculationLink 1067 - Disclosure - Collaboration and License Agreements - Ginkgo Agreement (Details) link:presentationLink link:definitionLink link:calculationLink 1068 - Disclosure - Collaboration and License Agreements - Genovis (Details) link:presentationLink link:definitionLink link:calculationLink 1069 - Disclosure - Collaboration and License Agreements - Cyrus Biotechnology, Inc. (Narrative) (Details) link:presentationLink link:definitionLink link:calculationLink 1070 - Disclosure - Collaboration and License Agreements - AskBio (Narrative) (Details) link:presentationLink link:definitionLink link:calculationLink 1071 - Disclosure - Collaboration and License Agreements - MIT (Narrative) (Details) link:presentationLink link:definitionLink link:calculationLink 1072 - Disclosure - Collaboration and License Agreements - Shenyang Sunshine Pharmaceutical Co., Ltd (Narrative) (Details) link:presentationLink link:definitionLink link:calculationLink 1073 - Disclosure - Income Taxes - Narrative (Details) link:presentationLink link:definitionLink link:calculationLink 1074 - Disclosure - Defined Contribution Plan (Details) link:presentationLink link:definitionLink link:calculationLink 1075 - Disclosure - Subsequent Events (Details) link:presentationLink link:definitionLink link:calculationLink