Marketable securities adjusted for other than temporary declines in fair value
Other-than-temporary Impairment Loss, Debt Securities, Available-for-Sale
Increase (Decrease) in Stockholders' Equity
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Total future minimum lease payments
Lessee, Operating Lease, Liability, to be Paid
Schedule of Cash and Cash Equivalents
Schedule of Cash and Cash Equivalents [Table Text Block]
Related Party Transactions [Abstract]
Related Party Transactions [Abstract]
Fair value, measurement with unobservable inputs reconciliation, recurring basis, liability, transfers, net
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Transfers, Net
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Weighted-average remaining contractual term
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term [Abstract]
n/a
Contract liabilities, additions
Contract with Customer, Liability, Increase From Cash Receipts
Contract with Customer, Liability, Increase From Cash Receipts
Property, Plant and Equipment [Abstract]
Property, Plant and Equipment [Abstract]
Preferred stock, shares outstanding (in shares)
Preferred Stock, Shares Outstanding
2024
Long-Term Debt, Maturity, Year Two
Total property and equipment
Property, Plant and Equipment, Gross
Income Tax Disclosure [Abstract]
Income Tax Disclosure [Abstract]
Consulting services expenses (less than)
Related Party Transaction, Expenses from Transactions with Related Party
Additional paid-in capital
Additional Paid in Capital
Number of amendments
License and Option Agreement, Number Of Amendments
License and Option Agreement, Number Of Amendments
Cash flows from investing activities
Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract]
Financial Instruments [Domain]
Financial Instruments [Domain]
Depreciation and amortization
Other Depreciation and Amortization
Accrued external research and development costs
Accrued Research And Development Costs Current
Carrying value as of the balance sheet date of research and development costs.
Depreciation expense
Depreciation
Issuance of common stock upon exercise of options (in shares)
Exercised (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Operating lease, weighted average discount rate, percent
Operating Lease, Weighted Average Discount Rate, Percent
Valuation Approach and Technique [Axis]
Valuation Approach and Technique [Axis]
Share-based Payment Arrangement [Abstract]
Share-Based Payment Arrangement [Abstract]
Domestic Tax Authority
Domestic Tax Authority [Member]
Net income (loss)
Net income
Net income (loss)
Net Income (Loss) Attributable to Parent
Measurement Input Type [Domain]
Measurement Input Type [Domain]
Potential common shares
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Schedule of Future Minimum Payments on the Term Loans
Schedule of Maturities of Long-Term Debt [Table Text Block]
Equity Component [Domain]
Equity Component [Domain]
Ownership [Axis]
Ownership [Axis]
Total assets
Assets, Fair Value Disclosure
Class of Warrant or Right [Line Items]
Class of Warrant or Right [Line Items]
Leases
Lessee, Operating Leases [Text Block]
Valuation Approach and Technique [Domain]
Valuation Approach and Technique [Domain]
Debt amendment fee included in debt discount
Payments of Financing Costs
Non-cash lease expense
Finance Lease, Right-of-Use Asset, Amortization
Related Party [Domain]
Related Party [Domain]
Plan Name [Axis]
Plan Name [Axis]
Employment Inducement Incentive Award Plan
Employment Inducement Incentive Award Plan [Member]
Employment Inducement Incentive Award Plan [Member]
Fair value
Marketable securities:
Debt Securities, Available-for-Sale
Dividend yield
Measurement Input, Expected Dividend Rate [Member]
Vesting period
Defined Contribution Plan Employers Matching Contribution Vesting Period
Period which an employee's right to exercise a plan is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.
Supplemental cash flow information
Supplemental Cash Flow Information [Abstract]
Forfeited (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Unrecognized compensation expense
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Plan Name [Domain]
Plan Name [Domain]
2022 (remainder)
Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year
Statement of Cash Flows [Abstract]
Statement of Cash Flows [Abstract]
Term loan facility
Long-Term Line of Credit
Entity Address, State or Province
Entity Address, State or Province
Level 1
Fair Value, Inputs, Level 1 [Member]
Outstanding, term
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Accrued interest
Accrued Interest, Current
Accrued Interest, Current
Award Type [Axis]
Award Type [Axis]
Issuance of common stock, license agreement (in shares)
Stock Issued During Period, Shares, New Issues under License Agreement
Stock Issued During Period, Shares, New Issues under License Agreement
Net cash (used in) operating activities
Net Cash Provided by (Used in) Operating Activities
Lease liability
Operating Lease, Liability, Current
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Summary of Available-for-Sale Marketable Securities
Debt Securities, Available-for-Sale [Table Text Block]
TAS Partners, LLC (affiliate of Timothy A. Springer, Ph.D.)
TAS Partners, LLC [Member]
TAS Partners, LLC [Member]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Forfeited (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Liability Class [Axis]
Liability Class [Axis]
Schedule of Cash and Cash Equivalents [Table]
Schedule of Cash and Cash Equivalents [Table]
Total liabilities
Liabilities
Operating lease, weighted average remaining lease term
Operating Lease, Weighted Average Remaining Lease Term
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Geographical [Axis]
Geographical [Axis]
Issuance of common stock
Stock Issued During Period, Value, New Issues
Accrued expenses and other liabilities
Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV [Domain]
Schedule of Property and Equipment
Property, Plant and Equipment [Table Text Block]
Marketable securities
Debt Securities, Available-for-Sale, Current
Preferred stock, shares issued (in shares)
Preferred Stock, Shares Issued
Document Type
Document Type
Weighted-average exercise price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Assets:
Assets, Fair Value Disclosure [Abstract]
Unvested at beginning of period (in dollars per share)
Unvested at end of period (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Debt
Debt Disclosure [Text Block]
Operating expenses:
Cost of Revenue [Abstract]
Cash flows from operating activities
Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract]
Entity Shell Company
Entity Shell Company
Aggregate amount of upfront and milestone-based payments
Aggregate Amount Of Upfront And Milestone Based Payments Paid
Aggregate Amount Of Upfront And Milestone Based Payments Paid
2023
Lessee, Operating Lease, Liability, to be Paid, Year One
Loan payable
Loans Payable, Current
Laboratory equipment
Laboratory Equipment [Member]
Represents information pertaining to laboratory equipment.
Aggregate amount for future payments upon achievement of clinical and regulatory approval milestones for products containing ImmTOR platform
Aggregate Amount For Future Payments Upon Achievement Of Clinical And Regulatory Approval Milestones For Products Containing ImmTOR Platform
Aggregate Amount For Future Payments Upon Achievement Of Clinical And Regulatory Approval Milestones For Products Containing ImmTOR Platform
Series B Preferred Stock Purchase Agreement
Series B Preferred Stock Purchase Agreement [Member]
Series B Preferred Stock Purchase Agreement
Financial Instrument [Axis]
Financial Instrument [Axis]
2025
Long-Term Debt, Maturity, Year Three
Affiliated Entity
Affiliated Entity [Member]
Other comprehensive income (loss):
Other Comprehensive Income (Loss), Tax [Abstract]
Schedule of Changes in Contract Liabilities
Contract with Customer, Contract Asset, Contract Liability, and Receivable [Table Text Block]
Document Period End Date
Document Period End Date
Equity securities, stock purchase agreement, par value per share (in dollars per share)
Equity Securities, Stock Purchase Agreement, Par Value Per Share
Equity Securities, Stock Purchase Agreement, Par Value Per Share
Debt Securities, Available-for-sale [Table]
Debt Securities, Available-for-Sale [Table]
Total assets
Assets
Debt Disclosure [Abstract]
Debt Disclosure [Abstract]
Net income (loss) per share:
Earnings Per Share [Abstract]
Extension receivable
License And Option Agreement, Extension Receivable
License And Option Agreement, Extension Receivable
Income Statement Location [Axis]
Income Statement Location [Axis]
Antidilutive Securities [Axis]
Antidilutive Securities [Axis]
Accrued expenses
Accrued expenses
Accrued Liabilities, Current
Underwriting Agreement
Underwriting Agreement [Member]
Underwriting Agreement
Less: Current portion of loan payable
Long-Term Debt, Current Maturities
Exercised (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Numerator:
Net Income (Loss) Available to Common Stockholders, Basic [Abstract]
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Accounting Policies [Abstract]
Accounting Policies [Abstract]
Number of obligations
Revenue, Number Of Performance Obligations
Revenue, Number Of Performance Obligations
Payroll and employee related expenses
Employee-related Liabilities, Current
Variable lease cost
Variable Lease, Cost
Contract assets, current
Contract with Customer, Asset, before Allowance for Credit Loss, Current
Stockholders’ equity:
Stockholders' Equity Attributable to Parent [Abstract]
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Net Income (Loss) Per Share
Earnings Per Share [Text Block]
Disclosure of Share-based Compensation Arrangements by Share-based Payment Award
Disclosure of Share-Based Compensation Arrangements by Share-Based Payment Award [Table Text Block]
Schedule of Weighted Average Assumptions Used
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Number of claims settled
Loss Contingency, Claims Settled, Number
Award Type [Domain]
Award Type [Domain]
Class of warrant or right, number of securities called by warrants or rights (in shares)
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Weighted average period for recognition
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
MIT
Exclusive Patent License Agreement With Massachusetts Institute Of Technology [Member]
Represents information pertaining to Exclusive patent license agreement with Massachusetts Institute of Technology. "
Proceeds from issuance of common stock under Employee Stock Purchase Plan
Proceeds from Stock Plans
Issuance of vested restricted stock units
Stock Issued During Period, Value, Restricted Stock Award, Gross
Computer equipment and software
Computer Equipment [Member]
Cash flows from financing activities
Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract]
Entity Registrant Name
Entity Registrant Name
Issuance of common stock, net (in shares)
Stock Issued During Period, Shares, New Issues
Subsequent Events
Subsequent Events [Text Block]
Dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Non-employee consultants
Non Employee Stock Option [Member]
An arrangement whereby a non-employee is entitled to receive in the future, subject to vesting and other restrictions, a number of shares in the entity at a specified price, as defined in the agreement.
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Entity Address, City or Town
Entity Address, City or Town
Defined Contribution Plan
Retirement Benefits [Text Block]
Leases [Abstract]
Leases [Abstract]
Expected life (in years)
Measurement Input, Expected Term [Member]
Period after first commercial sale when the Company is eligible to receive royalties
Eligible Period To Receive Royalties
Eligible Period To Receive Royalties
Estimated forfeitures rate
Share-based Compensation Arrangement By Share-based Payment Award Forfeitures Rate
Represents the percentage of forfeitures rate of the stock options based on the historical trends.
ESPP
Employee Stock Purchase Plan2016 [Member]
Represent information pertaining to the 2016 Employee Stock Purchase Plan.
Statement of Financial Position [Abstract]
Statement of Financial Position [Abstract]
Entity Emerging Growth Company
Entity Emerging Growth Company
Common stock, par value (in dollars per share)
Common Stock, Par or Stated Value Per Share
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Fair Value Measurements
Fair Value Disclosures [Text Block]
Trading Symbol
Trading Symbol
Entity File Number
Entity File Number
2016 Plan
Stock Incentive Plan2016 [Member]
Represents the information pertaining to the 2016 stock incentive plan, which provides for the granting of stock based awards to employees, directors, and consultants under terms and provisions established by the board of directors.
Deferred revenue
Long-term contract liability
Contract with Customer, Liability, Noncurrent
Research and development
Research and Development Expense
Fair Value by Liability Class [Domain]
Fair Value by Liability Class [Domain]
Equity offering costs in accrued liabilities
Equity Offering Costs In Accrued Liabilities
Equity Offering Costs In Accrued Liabilities
Restricted cash and cash equivalents
Restricted Cash and Cash Equivalents
Grants in period (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Restricted Stock Units (RSUs)
Restricted Stock Units (RSUs) [Member]
Vested, term
Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Weighted Average Remaining Contractual Term
Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Weighted Average Remaining Contractual Term
Risk-free interest rate
Measurement Input, Risk Free Interest Rate [Member]
Vested and expected to vest (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Money market funds (included in cash equivalents)
Cash and Cash Equivalents, Fair Value Disclosure
Contract liabilities:
Change In Contract With Customer, Liability [Roll Forward]
Change In Contract With Customer, Liability [Roll Forward]
Ginkgo Agreement
Ginkgo Agreement [Member]
Ginkgo Agreement
Accounts payable
Increase (Decrease) in Accounts Payable
Fair value as of December 31, 2021
Fair value as of June 30, 2022
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value
Subsequent Events [Abstract]
Subsequent Events [Abstract]
Marketable Securities and Investments
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Investment income
Investment Income, Net
Income Taxes
Income Tax Disclosure [Text Block]
Credit Facility [Domain]
Credit Facility [Domain]
Exercise price (in dollars per share)
Exercise price, beginning balance (in dollars per share)
Exercise price, ending balance (in dollars per share)
Class of Warrant or Right, Exercise Price of Warrants or Rights
Cash paid for interest
Interest Paid, Excluding Capitalized Interest, Operating Activities
Basic (in dollars per share)
Earnings Per Share, Basic
2025
Lessee, Operating Lease, Liability, to be Paid, Year Three
Schedule of Restricted Cash and Cash Equivalents
Restrictions on Cash and Cash Equivalents [Table Text Block]
Counterparty Name [Domain]
Counterparty Name [Domain]
Total stockholders’ equity
Beginning balance
Ending balance
Stockholders' Equity Attributable to Parent
Forfeited in period (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Line of Credit Facility [Line Items]
Line of Credit Facility [Line Items]
Ownership [Domain]
Ownership [Domain]
Entity Interactive Data Current
Entity Interactive Data Current
Sale of stock, number of shares issued in transaction (in shares)
Stock issued (in shares)
Sale of Stock, Number of Shares Issued in Transaction
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Table]
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Schedule Of Changes In The Warrant Liabilities
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Money market funds (included in cash equivalents)
Money Market Funds [Member]
Accumulated deficit
Retained Earnings [Member]
Unrecognized compensation expense related to unvested employee stock options
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Cash and Cash Equivalents [Line Items]
Cash and Cash Equivalents [Line Items]
Total lease cost
Lease, Cost
Common stock
Common Stock [Member]
Schedule of Lease, Cost
Lease, Cost [Table Text Block]
Number of shares authorized for grants (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Statement [Table]
Statement [Table]
Vested in period (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Document Quarterly Report
Document Quarterly Report
Furniture and fixtures
Furniture and Fixtures [Member]
Current assets:
Assets, Current [Abstract]
Lease liability
Operating Lease, Liability, Noncurrent
Research and development credits
Deferred Tax Assets, Tax Credit Carryforwards, Research
Vested
Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Intrinsic Value
Share-based Compensation Arrangement By Share-based Payment Award, Options, Vested, Outstanding, Intrinsic Value
Schedule of Fair Value Measurement Inputs and Valuation Techniques
Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]
Employer contribution made
Defined Contribution Plan, Cost
Leasehold improvements
Leasehold Improvements [Member]
Weighted-average fair value of common stock (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Weighted Average Fair Value
Weighed-average fair value relating to the share-based payment award.
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Accounts receivable
Accounts Receivable, after Allowance for Credit Loss, Current
Equity Components [Axis]
Equity Components [Axis]
Deferred revenue, additions
Contract with Customer, Liability, Deferred Revenue, Increase From Cash Receipts
Contract with Customer, Liability, Deferred Revenue, Increase From Cash Receipts
Recurring
Fair Value, Recurring [Member]
Related-party Transactions
Related Party Transactions Disclosure [Text Block]
Contractual payments defined in the Exclusive Patent License agreement
License And Option Agreement, Contractual Payments Made
License And Option Agreement, Contractual Payments Made
Document Fiscal Year Focus
Document Fiscal Year Focus
Takeda Agreement
Takeda Agreement [Member]
Takeda Agreement
Statement [Line Items]
Statement [Line Items]
Warrants and rights outstanding, term
Warrants and Rights Outstanding, Term
Fair Value Measurement Inputs and Valuation Techniques [Table]
Fair Value Measurement Inputs and Valuation Techniques [Table]
Unvested at beginning of period (in shares)
Unvested at end of period (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Redemption premium
Redemption Premium
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV [Axis]
Schedule of Operating Lease, Lease Income
Operating Lease, Lease Income [Table Text Block]
Unrealized losses
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Right-of-use asset, net
Operating Lease, Right-of-Use Asset
Accumulated other comprehensive loss
AOCI Attributable to Parent [Member]
Weighted average exercise price
Class Of Warrant Or Right, Exercise Price Of Warrants Or Rights [Roll Forward]
Class Of Warrant Or Right, Exercise Price Of Warrants Or Rights
Vested and expected to vest (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Document Transition Report
Document Transition Report
Local Phone Number
Local Phone Number
Extension term
License And Option Agreement, Extension Term
License And Option Agreement, Extension Term
Equity securities, stock purchase agreement, purchase price per share (in dollars per share)
Equity Securities, Stock Purchase Agreement, Purchase Price Per Share
Equity Securities, Stock Purchase Agreement, Purchase Price Per Share
Summary of Options Activity
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Operating income (loss)
Operating Income (Loss)
Federal operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Domestic
Recent Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
2019 Warrants
2019 Warrants [Member]
2019 Warrants
Investments
Equity securities without readily determinable fair value, amount
Equity Securities without Readily Determinable Fair Value, Amount
Prepaid expenses, deposits and other assets
Increase (Decrease) in Prepaid Expense and Other Assets
Common stock, shares outstanding (in shares)
Beginning balance (in shares)
Ending balance (in shares)
Common Stock, Shares, Outstanding
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset [Axis]
Total liabilities
Liabilities, Fair Value Disclosure
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Geographical [Domain]
Geographical [Domain]
Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table]
Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
SOBI Purchase Agreement
SOBI Purchase Agreement [Member]
SOBI Purchase Agreement [Member]
Preferred stock, par value (in dollars per share)
Preferred Stock, Par or Stated Value Per Share
Cost share percentage
Collaborative Arrangement, Cost Share Percentage
Collaborative Arrangement, Cost Share Percentage
2026
Lessee, Operating Lease, Liability, to be Paid, Year Four
Granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Additional paid-in capital
Additional Paid-in Capital [Member]
Document Fiscal Period Focus
Document Fiscal Period Focus
Net income (loss) per share:
Earnings Per Share, Basic [Abstract]
Venture debt termination fee
Debt Instrument, Termination Fee
Debt Instrument, Termination Fee
Diluted (in shares)
Weighted‑average common shares outstanding—diluted (in shares)
Weighted Average Number of Shares Outstanding, Diluted
Less accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Expected term
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement
Collaborative Arrangement [Member]
Debt Securities, Available-for-sale [Line Items]
Debt Securities, Available-for-Sale [Line Items]
Common stock, $0.0001 par value; 350,000,000 shares authorized; 152,713,211 and 123,622,965 shares issued and outstanding as of June 30, 2022 and December 31, 2021, respectively
Common Stock, Value, Issued
Future additional payments, expected
License And Option Agreement, Future Additional Payments, Expected
License And Option Agreement, Future Additional Payments, Expected
Grants in period (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Cash, cash equivalents, restricted cash and marketable securities
Cash, Cash Equivalents, Restricted Cash And Restricted Cash Equivalents And Debt Securities, Available-For-Sale
Cash, Cash Equivalents, Restricted Cash And Restricted Cash Equivalents And Debt Securities, Available-For-Sale
Issuance of vested restricted stock units (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Gross
Schedule of Potential Common Shares Issuable Upon Conversion of Warrants
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Underwriting Agreement - 2022 Warrants
Underwriting Agreement - 2022 Warrants [Member]
Underwriting Agreement - 2022 Warrants
Summary of Assets Measured at Fair Value on a Recurring Basis
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Vested (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Weighted Average Exercise Price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Weighted Average Exercise Price
Equity securities, stock purchase agreement, shares purchased (in shares)
Equity Securities, Stock Purchase Agreement, Shares Purchased
Equity Securities, Stock Purchase Agreement, Shares Purchased
Short-term lease cost
Short-Term Lease, Cost
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Preferred stock, shares authorized (in shares)
Preferred Stock, Shares Authorized
Accrued professional and consulting services
Accrued Audit Fees, Current
Accrued Audit Fees, Current
Number of Warrants
Class Of Warrant Or Right [Roll Forward]
Class Of Warrant Or Right
Cash, cash equivalents, and restricted cash at beginning of period
Cash, cash equivalents, and restricted cash at end of period
Total cash, cash equivalents, and restricted cash
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents
Foreign currency translation adjustment
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Warrants and rights outstanding, measurement input
Warrants and Rights Outstanding, Measurement Input
Current liabilities:
Liabilities, Current [Abstract]
Adjusted net income (loss)
Net Income (Loss) Available to Common Stockholders, Basic
Proceeds from exercise of stock options
Proceeds from Stock Options Exercised
Common stock, shares issued (in shares)
Common Stock, Shares, Issued
Vested and expected to vest, term
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Deferred revenue
Short-term contract liability
Contract with Customer, Liability, Current
Purchase of property and equipment not yet paid
Capital Expenditures Incurred but Not yet Paid
Foreign currency transaction, net
Foreign Currency Transaction Gain (Loss), before Tax
Warrant liabilities
Warrant liabilities
Warrants and Rights Outstanding
Spark License Agreement
License Agreement Terms [Member]
Income Statement Location [Domain]
Income Statement Location [Domain]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Amendment Flag
Amendment Flag
Net cash provided by (used in) investing activities
Net Cash Provided by (Used in) Investing Activities
Operating lease cost
Operating Lease, Cost
Face value
Debt Instrument, Face Amount
Issuance of common stock under Employee Stock Purchase Plan
Stock Issued During Period, Value, Employee Stock Purchase Plan
Total comprehensive income (loss)
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Construction in process
Construction in Progress [Member]
Unrealized gains
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Entity Current Reporting Status
Entity Current Reporting Status
Goodwill and Intangible Assets Disclosure [Abstract]
Goodwill and Intangible Assets Disclosure [Abstract]
Long-term Debt, Fiscal Year Maturity [Abstract]
Long-Term Debt, Fiscal Year Maturity [Abstract]
License and option agreement, written day notice period before cancellation
License And Option Agreement, Written Day Notice Period Before Cancellation
License And Option Agreement, Written Day Notice Period Before Cancellation
Development milestone
License And Option Agreement, Development Milestone
License And Option Agreement, Development Milestone
Disaggregation of Revenue [Table]
Disaggregation of Revenue [Table]
Sarepta Therapeutics, Inc.
Sarepta Therapeutics, Inc. [Member]
Sarepta Therapeutics, Inc. [Member]
Issuance of common stock under Employee Stock Purchase Plan (in shares)
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Counterparty Name [Axis]
Counterparty Name [Axis]
Schedule of Related Party Transactions
Schedule of Related Party Transactions [Table Text Block]
Founders
Founder [Member]
Represents information pertaining to founder member.
Beginning balance (in shares)
Ending balance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Less: Debt discount
Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net
Cash and Cash Equivalents [Axis]
Cash and Cash Equivalents [Axis]
Number of shares authorized, increase (in shares)
Share-Based Compensation Arrangement By Share-Based Payment Award, Number Of Shares Available For Grant, Increase (Decrease)
Share-Based Compensation Arrangement By Share-Based Payment Award, Number Of Shares Available For Grant, Increase (Decrease)
Accrued Expenses
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Deferred revenue, beginning of period
Deferred revenue, end of period
Contract with Customer, Liability, Deferred Revenue
Contract with Customer, Liability, Deferred Revenue
Less: Change in fair value of liability warrants
Preferred Stock Dividends and Other Adjustments
Schedule of Stock by Class [Table]
Schedule of Stock by Class [Table]
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Effect of exchange rate changes on cash
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Continuing Operations
Property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Net
Cash paid for amounts included in the measurement of lease liabilities:
Operating Lease, Payments
Office equipment
Office Equipment [Member]
Change in fair value
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings
Outstanding common stock options
Share-Based Payment Arrangement, Option [Member]
Expected volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Aggregate intrinsic value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value [Abstract]
n/a
Issuance of common stock upon exercise of options
Stock Issued During Period, Value, Stock Options Exercised
Forfeited in period (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Total minimum principal payments
Long-Term Debt
Other income, net
Other Nonoperating Income (Expense)
Share price (in dollars per share)
Sale of Stock, Price Per Share
Common stock, shares authorized (in shares)
Common Stock, Shares Authorized
Schedule of Related Party Transactions, by Related Party [Table]
Schedule of Related Party Transactions, by Related Party [Table]
Statement of Comprehensive Income [Abstract]
Statement of Comprehensive Income [Abstract]
Class of Warrant or Right [Axis]
Class of Warrant or Right [Axis]
Total operating expenses
Collaboration expense
Operating Expenses
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax
Employees
Shares available for future stock incentive awards
Employee stock option grants
Share-Based Payment Arrangement [Member]
Long-term restricted cash
Restricted Cash and Cash Equivalents, Noncurrent
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Deferred revenue
Increase (Decrease) in Contract with Customer, Liability
Total current assets
Assets, Current
Income taxes payable
Taxes Payable, Current
Revenue recognized
Contract liabilities, deductions
Contract with Customer, Liability, Revenue Recognized
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Entity Smaller Reporting Company
Entity Small Business
Schedule of Stockholders' Equity Note, Warrants or Rights
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Equity
Stockholders' Equity Note Disclosure [Text Block]
Measurement Frequency [Domain]
Measurement Frequency [Domain]
Shares of common stock issued to employees under the ESPP (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Issued in Period
Valuation technique, option pricing model
Valuation Technique, Option Pricing Model [Member]
Line of Credit Facility [Table]
Line of Credit Facility [Table]
Purchases of marketable securities
Payments to Acquire Debt Securities, Available-for-Sale
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Number of Options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Property and Equipment
Property, Plant and Equipment Disclosure [Text Block]
Non-cash interest expense
Paid-in-Kind Interest
Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset [Domain]
Accounts receivable
Increase (Decrease) in Accounts Receivable
Title of 12(b) Security
Title of 12(b) Security
Description of the Business
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Fair value, measurement with unobservable inputs reconciliation, recurring basis, asset, transfers, net
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Transfers, Net
Payables and Accruals [Abstract]
Payables and Accruals [Abstract]
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Class of Warrant or Right [Table]
Class of Warrant or Right [Table]
Class of Stock [Line Items]
Class of Stock [Line Items]
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Lease liabilities
Operating Lease, Liability
Expected volatility
Measurement Input, Price Volatility [Member]
Amortization of premiums and discounts on marketable securities
Accretion (Amortization) of Discounts and Premiums, Investments
Investments, Debt and Equity Securities [Abstract]
Investments, Debt and Equity Securities [Abstract]
Issuance of common stock, license agreement
Stock Issued During Period, Value, New Issues under License Agreement
Stock Issued During Period, Value, New Issues under License Agreement
Other financing fees
Adjustments to Additional Paid in Capital, Other
AskBio License
AskBio License [Member]
AskBio License [Member]
Liabilities and stockholders’ equity
Liabilities and Equity [Abstract]
Milestone receivable
License And Option Agreement, Milestone Receivable
License And Option Agreement, Milestone Receivable
Granted (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Fair Value, Recurring and Nonrecurring [Table]
Fair Value, Recurring and Nonrecurring [Table]
Amortized cost
Debt Securities, Available-for-Sale, Amortized Cost
Weighted average common shares outstanding:
Denominator:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Sale common stock
Sale of Stock, Consideration Received on Transaction
Accounts payable
Accounts Payable, Current
Income Tax Authority [Axis]
Income Tax Authority [Axis]
Debt discount
Debt Instrument, Unamortized Discount
Vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Canceled (in dollars per share)
Warrant, Exercise Price, Canceled
Warrant, Exercise Price, Canceled
Warrants to purchase common stock
Warrant liabilities
Exercise of warrants
Warrant [Member]
Entity Filer Category
Entity Filer Category
Net proceeds from issuance of common stock
Shares issued, value
Proceeds from Issuance of Common Stock
Basic (in shares)
Weighted-average common shares outstanding, basic (in shares)
Weighted Average Number of Shares Outstanding, Basic
Loss contingency accrual
Loss Contingency Accrual
Liabilities:
Liabilities, Fair Value Disclosure [Abstract]
Total stock-based compensation expense
Stock-based compensation expense
Share-Based Payment Arrangement, Expense
Cyrus Biotechnology, Inc.
Cyrus Biotechnology, Inc. [Member]
Cyrus Biotechnology, Inc.
Noncash investing and financing activities
Noncash Investing and Financing Items [Abstract]
Commitments and contingencies
Commitments and Contingencies
Security Exchange Name
Security Exchange Name
Beginning balance (in dollars per share)
Ending balance (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Collaboration and licensing
Accrued Collaboration and Licensing
Accrued Collaboration and Licensing
Class of Warrant or Right [Domain]
Class of Warrant or Right [Domain]
Issuance of common stock, license agreement in stock-based compensation expense
Stock Issued
At-The-Market Offering
At-The-Market Offering [Member]
At-The-Market Offering [Member]
Preferred stock, $0.0001 par value; 10,000,000 shares authorized; no shares issued and outstanding as of June 30, 2022 and December 31, 2021
Preferred Stock, Value, Issued
License Agreement For Pompe Disease
License Agreement For Pompe Disease [Member]
License Agreement For Pompe Disease [Member]
2020 Term Loans
2020 Term Loans [Member]
2020 Term Loans
Schedule of Term Loan And Unamortized Debt Discount Balances
Schedule of Debt [Table Text Block]
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
General and administrative
General and Administrative Expense [Member]
Collaboration and license revenue
Revenue from Contract with Customer, Excluding Assessed Tax
Corporate bonds
Corporate Bond Securities [Member]
Income taxes payable
Increase (Decrease) in Income Taxes Payable
Contract assets, noncurrent
Contract with Customer, Asset, before Allowance for Credit Loss, Noncurrent
Total (in shares)
Common stock authorized and reserved for future issuance (in shares)
Common Stock, Capital Shares Reserved for Future Issuance
Cover [Abstract]
Cover [Abstract]
Schedule of Long-term Debt Instruments [Table]
Schedule of Long-Term Debt Instruments [Table]
License and option agreement, payments made relative to calculated premium paid for initial equity investment made under the purchase agreement
License And Option Agreement, Calculated Premium Paid For Equity Investment Under Purchase Agreement
License And Option Agreement, Calculated Premium Paid For Equity Investment Under Purchase Agreement
Level 3
Fair Value, Inputs, Level 3 [Member]
Stock Incentive Plans
Share-Based Payment Arrangement [Text Block]
Schedule of Stock-Based Compensation
Share-Based Payment Arrangement, Cost by Plan [Table Text Block]
Other assets
Other Assets
Revenue Arrangements
Revenue from Contract with Customer [Text Block]
3SBio License
License Agreement With Shenyang Sunshine Pharmaceutical Company Limited [Member]
Represents information pertaining to License agreement with Shenyang Sunshine Pharmaceutical co., ltd.
Risk-free interest rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Total liabilities and stockholders’ equity
Liabilities and Equity
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
2022 Warrants
2022 Warrants [Member]
2022 Warrants
Related Party [Axis]
Related Party [Axis]
Cash maintained in Russian bank accounts
Cash
Sales milestone payments
License And Option Agreement, Sales Milestone Payments That May Be Received
License And Option Agreement, Sales Milestone Payments That May Be Received
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Issuances
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Issuances
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Level 2
Fair Value, Inputs, Level 2 [Member]
Net proceeds from issuance of common stock and common warrants
Proceeds From Issuance Of Common Stock And Warrants
Proceeds From Issuance Of Common Stock And Warrants
Current Fiscal Year End Date
Current Fiscal Year End Date
Option term
License And Option Agreement, Option Term
License And Option Agreement, Option Term
Less imputed interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Adjusted net income (loss)
Net Income (Loss) Available to Common Stockholders, Diluted
Diluted (in dollars per share)
Earnings Per Share, Diluted
Sale of Stock [Domain]
Sale of Stock [Domain]
Award vesting term
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
(Gain) on disposal of property and equipment
Gain (Loss) on Disposition of Property Plant Equipment
Schedule of Authorized Shares of Common Stock for Future Issuance
Schedule of Stock by Class [Table Text Block]
Stock-based compensation expense
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Change in fair value of warrant liabilities
Warrant liabilities revaluation
Fair Value Adjustment of Warrants
Total current liabilities
Liabilities, Current
Vested (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested, Number of Shares
2024
Lessee, Operating Lease, Liability, to be Paid, Year Two
Russian subsidiary
RUSSIAN FEDERATION
Remaining performance obligation
Revenue, Remaining Performance Obligation, Amount
Non-current liabilities:
Other Liabilities, Noncurrent [Abstract]
Schedule of Lessee, Operating Lease, Liability, Maturity
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
Entity Address, Address Line One
Entity Address, Address Line One
Contract assets
Contract with Customer, Asset, before Allowance for Credit Loss
Income Tax Authority [Domain]
Income Tax Authority [Domain]
Deferred revenue related to agreement
Contract liabilities, beginning of period
Contract liabilities, end of period
Contract with Customer, Liability
2008 Plan, 2016 Plan, and 2018 Inducement Incentive Award Plan
2008 Plan, 2016 Plan, and 2018 Inducement Incentive Award Plan [Member]
2008 Plan, 2016 Plan, and 2018 Inducement Incentive Award Plan
Research and development
Research And Development [Member]
Represents the information pertaining to research and development expenses included in the income statement.
Fair Value Disclosures [Abstract]
Fair Value Disclosures [Abstract]
Subsidiary, Sale of Stock [Line Items]
Subsidiary, Sale of Stock [Line Items]
Interest expense
Interest Expense
Credit Facility [Axis]
Credit Facility [Axis]
Unrealized gain on marketable securities
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Accrued patent fees
Accrued Patent Fees Current
Carrying value as of the balance sheet date of patent fees.
Schedule of Accrued Expenses
Schedule of Accrued Liabilities [Table Text Block]
Cash and Cash Equivalents [Domain]
Cash and Cash Equivalents [Domain]
Equity [Abstract]
Equity [Abstract]
Vested in period (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Unvested restricted stock units
Restricted Stock Units, Unvested [Member]
Restricted Stock Units, Unvested
Entity Tax Identification Number
Entity Tax Identification Number
Exercises
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Exercises In Period
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Exercises In Period
Issuances (in shares)
Stock Issued During Period Shares Warrants Issued
Stock Issued During Period Shares Warrants Issued
Revenue from Contract with Customer [Abstract]
Revenue from Contract with Customer [Abstract]
Thereafter
Lessee, Operating Lease, Liability, To Be Paid, After Year Four
Lessee, Operating Lease, Liability, To Be Paid, After Year Four
Issuance of common stock through at-the-market offering, net (in shares)
Stock Issued During Period, Shares, Other
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Net change in cash, cash equivalents, and restricted cash
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Exercise of warrants (in shares)
Stock Issued During Period Shares Warrants Exercised
Number of warrants exercised during the current period.
Dilutive effect of employee equity incentive plans and outstanding warrants (in shares)
Weighted Average Number of Shares Outstanding, Diluted, Adjustment
Commercial paper
Commercial Paper [Member]
Entity Central Index Key
Entity Central Index Key
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name [Domain]
Measurement Frequency [Axis]
Measurement Frequency [Axis]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Payment obligation
Collaborative Arrangement, Payment Obligation
Collaborative Arrangement, Payment Obligation
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Initial upfront execution fee payment
License And Option Agreement, Execution Fee Payment
License And Option Agreement, Execution Fee Payment
Canceled (in shares)
Canceled (in shares)
Stock Issued During Period, Shares, Warrants Canceled
Stock Issued During Period, Shares, Warrants Canceled
Other
Other Accrued Liabilities, Current
Measurement Input Type [Axis]
Measurement Input Type [Axis]
City Area Code
City Area Code
General and administrative
General and Administrative Expense
Assets
Assets [Abstract]
Retirement Benefits [Abstract]
Retirement Benefits [Abstract]
Collaboration and License Agreements
Collaboration And License Agreements [Text Block]
Collaboration And License Agreements
Issuance (in dollars per share)
Warrant, Exercise Price, Increase
Statement of Stockholders' Equity [Abstract]
Statement of Stockholders' Equity [Abstract]
Sale of Stock [Axis]
Sale of Stock [Axis]
Proceeds from maturities of marketable securities
Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-Sale
Clinical and commercial milestone payment, expected
License And Option Agreement, Clinical And Commercial Milestone Payment, Expected
License And Option Agreement, Clinical And Commercial Milestone Payment, Expected
2023
Long-Term Debt, Maturity, Year One
Stock-based compensation expense
Share-Based Payment Arrangement, Noncash Expense
Upfront cash payment
License And Option Agreement, Upfront Cash Payment
License And Option Agreement, Upfront Cash Payment
Weighted average grant date fair value of stock options (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Issuance of common stock through at-the-market offering, net
Stock Issued During Period, Value, Other
Initial up-front cash payment
License And Option Agreement, Initial Up-Front Cash Payment
License And Option Agreement, Initial Up-Front Cash Payment
Revenue recognized from performance obligations related to prior periods as a result of the change in transaction price
Contract with Customer, Liability, Cumulative Catch-up Adjustment to Revenue, Change in Estimate of Transaction Price
Class of warrant or right, outstanding, beginning balance (in shares)
Class of warrant or right, outstanding, ending balance (in shares)
Class of Warrant or Right, Outstanding
Loan payable, net of current portion
Loans Payable, Noncurrent
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Disaggregation of Revenue [Line Items]
Disaggregation of Revenue [Line Items]
Computation of Basic and Diluted Net Loss Per Share
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Milestone payment
License And Option Agreement, Milestone Payments
License And Option Agreement, Milestone Payments
Deferred revenue, deductions
Contract with Customer, Liability, Deferred Revenue, Revenue Recognized
Contract with Customer, Liability, Deferred Revenue, Revenue Recognized