Document and Entity Information Statement [Table] Statement [Line Items] Entity Registrant Name Entity Central Index Key Document Type Document Period End Date Amendment Flag Current Fiscal Year End Date Entity Current Reporting Status Entity Filer Category Entity Common Stock, Shares Outstanding Document Fiscal Year Focus Document Fiscal Period Focus Statement of Financial Position [Abstract] Assets [Abstract] Assets Assets, Current [Abstract] Current Assets: Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents at end of period Cash and cash equivalents at beginning of period Cash and cash equivalents Short-term Investments Short term deposits and investments Restricted Cash and Cash Equivalents, Current Restricted cash Accounts Receivable, Net, Current Accounts receivable Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Assets, Current Total current assets Property, Plant and Equipment, Net Property and equipment, net Property and equipment, net Restricted Cash and Investments, Noncurrent Restricted cash and other deposits Other Assets, Noncurrent Other assets Assets Total assets Liabilities and Equity [Abstract] Liabilities, Current [Abstract] Current liabilities: Accounts Payable, Current Accounts payable Accrued Liabilities, Current Accrued expenses Accrued liabilities Loans Payable, Current Loans payable, current portion Deferred Revenue, Current Deferred revenue, current portion Represents information pertaining to current contingently repayable grant funding. Contingently Repayable Grant Funding Current Contingently repayable grant funding Liabilities, Current Total current liabilities Other Liabilities, Noncurrent [Abstract] Non-current liabilities: Deferred Rent Credit, Noncurrent Deferred rent and lease incentive Loans Payable, Noncurrent Loans payable, net of current portion Deferred Revenue, Noncurrent Deferred revenue, net of current portion Other Liabilities, Noncurrent Other long-term liabilities Liabilities Total liabilities Commitments and Contingencies. Commitments and contingencies (Notes 7 and 12) Temporary Equity [Abstract] Redeemable convertiable preferred stock Temporary Equity, Carrying Amount, Attributable to Parent Balance Balance Carrying value Stockholders' Equity Attributable to Parent [Abstract] Stockholders' equity (deficit): Preferred Stock, Value, Issued Preferred stock, $0.0001 par value; 10,000,000 and 0 shares authorized; 0 and 0 shares issued and outstanding at June 30, 2016 and December 31, 2015, respectively. Common Stock, Value, Issued Common stock, $0.0001 par value; 200,000,000 and 62,164,377 shares authorized at June 30, 2016 and December 31, 2015 respectively; 17,900,547 and 2,180,976 shares issued, 17,895,824 and 2,173,399 shares outstanding as of June 30, 2016 and December 31, 2015 respectively Additional Paid in Capital Additional paid in capital Retained Earnings (Accumulated Deficit) Accumulated deficit Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive loss Stockholders' Equity Attributable to Parent Balance Balance Total stockholders' equity (deficit) Liabilities and Equity Total liabilities, redeemable convertible preferred stock and stockholders' equity (deficit) Temporary Equity, Par or Stated Value Per Share Redeemable convertible preferred stock, par value Par value Temporary Equity, Shares Authorized Redeemable convertible preferred stock, authorized Temporary Equity, Shares Issued Redeemable convertible preferred stock, issued Issued Temporary Equity, Shares Outstanding Balance (in shares) Balance (in shares) Outstanding Preferred Stock, Par or Stated Value Per Share Preferred stock, par value Preferred Stock, Shares Authorized Preferred stock, shares authorized Preferred Stock, Shares Issued Preferred stock, shares issued Preferred Stock, Shares Outstanding Preferred stock, shares outstanding Common Stock, Par or Stated Value Per Share Common stock, par value Common Stock, Shares Authorized Common stock, authorized Common Stock, Shares, Issued Common stock, issued Common Stock, Shares, Outstanding Common stock, outstanding Statement of Comprehensive Income [Abstract] Revenues Grant and collaboration revenue Cost of Revenue [Abstract] Operating expenses: Research and Development Expense Research and development General and Administrative Expense General and administrative Operating Expenses Total operating expenses Operating Income (Loss) Operating Income (Loss), Total Investment Income, Net Investment income Foreign Currency Transaction Gain (Loss), before Tax Foreign currency transaction gain (loss), net Interest Expense Interest expense Interest expense Other Expenses Other expense, net Net Income (Loss) Attributable to Parent Net loss Net loss Other Comprehensive Income (Loss), Tax [Abstract] Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax Foreign currency translation adjustment Currency translation adjustment Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss Temporary Equity, Dividends, Adjustment Accretion of redeemable convertible preferred stock Net Income (Loss) Available to Common Stockholders, Basic Net loss attributable to common stockholders Earnings Per Share, Basic and Diluted Net loss per share attributable to common Basic and diluted Weighted Average Number of Shares Outstanding, Basic and Diluted Weighted average common shares outstanding Basic an diluted Statement of Stockholders' Equity [Abstract] Increase (Decrease) in Temporary Equity [Roll Forward] Temporary Equity, Accretion to Redemption Value Accrued dividends and accretion of preferred stock to redemption value Accretion of preferred stock to redemption value Value of conversion of convertible stock during the period. Temporary Equity Conversion Of Convertible Stock Value Conversion of convertible stock upon listing Number of shares of convertible stock that was converted during the period. Temporary Equity Conversion Of Convertible Stock Shares Conversion of convertible stock upon listing (in shares) Increase (Decrease) in Stockholders' Equity [Roll Forward] Shares, Outstanding Balance (in shares) Balance (in shares) Represents the aggregate value of stock related to Restricted Common Stock vested during the period. Stock Vested During Period Value Restricted Common Stock Vesting of restricted common stock Represents the total number of shares vested during the period as a result of Restricted Common Stock. Stock Vested During Period Share Restricted Common Stock Vesting of restricted common stock (in shares) Stock Issued During Period, Value, Stock Options Exercised Issuance of common stock upon exercise of options Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Issuance of common stock upon exercise of options (in shares) Number of shares issued upon the early exercise of stock options Number of wwarrants exercised during the current period. Stock Issued During Period Shares Warrants Exercised Exercise of common warrants (in shares) Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Stock based compensation expense Represents the value of accretion of temporary equity to redemption value during the period. Stockholders Equity Accretion to Redemption Value Accretion of preferred stock to redemption value Stock Issued During Period, Value, Conversion of Convertible Securities Conversion of convertible stock upon listing Stock Issued During Period, Shares, Conversion of Convertible Securities Conversion of convertible securities upon listing (in shares) Stock Issued During Period, Value, New Issues Issuance of common stock, initial public offering net of issuance costs of $9,224 Stock Issued During Period, Shares, New Issues Number of shares issued Common stock issued and sold The gross value of stock issued during the period upon the conversion of preferred stock warrants. Stock Issued During Period Value Conversion Preferred Stock Warrants Conversion of preferred stock warrants into warrants for the purchase of common stock Amount of stock issuance costs incurred during the period. Stock Issuance Costs Stock issuance costs Statement of Cash Flows [Abstract] Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Operating activities Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Depreciation Depreciation Depreciation expense Allocated Share-based Compensation Expense Stock-based compensation expense Paid-in-Kind Interest Non-cash interest expense Fair Value Adjustment of Warrants Change in fair value of redeemable convertible preferred stock warrant Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Accounts Receivable Accounts receivable Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other assets Increase (Decrease) in Restricted Cash for Operating Activities Restricted cash and other deposits Increase (Decrease) in Accounts Payable Account payable Increase (Decrease) in Deferred Revenue Deferred revenue The increase (decrease) during the reporting period in contingently repayable grant funding that are used in an entity's business. Increase Decrease In Contingently Repayable Grant Funding Contingently repayable grant funding received Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities accrued expenses and other liabilities Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash used in operating activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Investing activities Proceeds from Maturities, Prepayments and Calls of Short-term Investments Maturities of short term government obligations Payments to Acquire Property, Plant, and Equipment purchase of property and equipment Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash provided by (used in ) investing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Financing activities The cash proceeds fromthe vesting of restricted stock. Proceeds From Vesting Of Restricted Stock Vesting of restricted stock Repayments of Long-term Debt Principle payments on loan payable Payments of Stock Issuance Costs Deferred IPO costs paid Issuance costs Proceeds from Convertible Debt Issuance of convertible note Proceeds from Issuance Initial Public Offering Net proceeds Net proceeds Proceeds from Initial Public Offering Proceeds from Stock Options Exercised Exercise of stock options Net Cash Provided by (Used in) Financing Activities, Continuing Operations Net cash provided by financing activities Effect of Exchange Rate on Cash and Cash Equivalents, Continuing Operations Effect of exchange rate changes on cash Cash and Cash Equivalents, Period Increase (Decrease) Net (decrease) increase in cash and cash equivalents Supplemental Cash Flow Information [Abstract] Cash paid during the year for: Interest Paid Interest Noncash Investing and Financing Items [Abstract] Supplemental Noncash Financing Activities: Reclassification of deferred IPO costs from non-current assets to additional paid-in capital. Noncash or Partial Noncash Reclassification Of Deferred IPO Costs From Non Current Assets To Additional Paid In Capital Reclassification of IPO costs from non-current assets to additional paid-in capital A noncash or partial noncash transaction for initial public offering costs in accounts payable and accrued liabilities. Noncash or Partial Noncash Transaction Initial Public Offering Costs In Accounts Payable And Accrued Liabilities Initial public offering costs in accounts payable and accrued liabilities Nature of business and basis of presentation Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] Nature of business and basis of presentation Summary of significant accounting policies Significant Accounting Policies [Text Block] Summary of significant accounting policies Net Loss Per Share Earnings Per Share [Text Block] Net Loss Per Share Fair Value Measurements Fair Value Disclosures [Text Block] Fair Value Measurements Property and Equipment Property, Plant and Equipment Disclosure [Text Block] Property and Equipment Accrued Expenses Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block] Accrued Expenses Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] Commitments and Contingencies Debt Debt Disclosure [Text Block] Debt Preferred Stock The entire disclosure for temporary equity. Temporary Equity Disclosure [Text Block] Preferred Stock Common Stock. Shareholders' Equity and Share-based Payments [Text Block] Common Stock Stock Incentive Plans Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Stock Incentive Plans NA Revenue Arrangements Collaborative Arrangement Disclosure [Text Block] Revenue Arrangements Related-Party Transactions Related Party Transactions Disclosure [Text Block] Related-Party Transactions NA Technology License Agreements The entire disclosure for technology license agreements. Techonology License Agreements [Text Block] Technology License Agreements Income Taxes Income Tax Disclosure [Text Block] Income Taxes 401(k) Savings Plan Defined Contribution Plan Disclosure [Line Items] Pension and Other Postretirement Benefits Disclosure [Text Block] 401(k) Savings Plan Subsequent Events Subsequent Events [Text Block] Subsequent events Consolidation, Policy [Policy Text Block] Principles of Consolidation Foreign Currency Transactions and Translations Policy [Policy Text Block] Foreign Currency Use of Estimates, Policy [Policy Text Block] Use of Estimates Segment Reporting, Policy [Policy Text Block] Segment Information Disclosure of accounting policy for cash equivalents and short term investments. Cash Equivalents And Short Term Investments [Policy Text Block] Cash Equivalents and Short Term Investments Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentrations of Credit Risk and Off-Balance Sheet Risk Fair Value of Financial Instruments, Policy [Policy Text Block] Fair Value of Financial Instruments Property, Plant and Equipment, Policy [Policy Text Block] Property and Equipment Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block] Impairment of Long-Lived Assets Debt, Policy [Policy Text Block] Debt Issuance Costs Revenue Recognition, Policy [Policy Text Block] Revenue Recognition Collaborative Arrangement, Accounting Policy [Policy Text Block] Collaborative revenue Disclosure of accounting policy for revenue recognition for revenue from grants. Revenue Recognition Grant Revenue [Policy Text Block] Grant agreements Research and Development Expense, Policy [Policy Text Block] Research and Development Costs Disclosure of accounting policy for clinical trial costs. Clinical Trial Costs [Policy Text Block] Clinical Trial Costs Income Tax, Policy [Policy Text Block] Income Taxes Disclosure of accounting policy for warrants. Warrants [Policy Text Block] Warrants Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block] Stock-Based Compensation Comprehensive Income, Policy [Policy Text Block] Comprehensive Loss Earnings Per Share, Policy [Policy Text Block] Net Loss Per Share Disclosure of accounting policy for deferred rent. Deferred Rent [Policy Text Block] Deferred Rent Contingent Liability Reserve Estimate, Policy [Policy Text Block] Contingent Liabilities New Accounting Pronouncements, Policy [Policy Text Block] Recent Accounting Pronouncements Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Schedule of computation of basic and diluted net loss per share Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Schedule of potential common shares issuable upon conversion of warrants to purchase common stock and stock options that are excluded from the computation of diluted weighted average shares outstanding